Huang, Jianmei Li, Meiying Mei, Bingjie Li, Junyang Zhu, Yi Guo, Qiaoshan Huang, Jianming Zhang, Guonan
Published in
Journal of translational medicine
Aberrant sialoglycans on the surface of tumor cells shield potential tumor antigen epitopes, escape recognition, and suppress activation of immunocytes. α2,3/α2,6Gal- and α2,6GalNAc (Gal/GalNAc)-linked sialic acid residues of sialoglycans could affect macrophage galactose-type lectins (MGL) mediated-antigen uptake and presentation and promote siali...
Zhao, Wenbo Wu, Yibo Zhao, Feihu Xue, Zhiyi Liu, Wenyu Cao, Zenxin Zhao, Zhimin Huang, Bin Han, Mingzhi Li, Xingang
...
Published in
Journal of Translational Medicine
Background Small peptides encoded by long non-coding RNAs (lncRNAs) have attracted attention for their various functions. Recent studies indicate that these small peptides participate in immune responses and antigen presentation. However, the significance of RNA modifications remains unclear. Methods Thirteen non-m6A-related neoantigen-coding lncRN...
Feng, Zi-Hao Liang, Yan-Ping Cen, Jun-Jie Yao, Hao-Hua Lin, Hai-Shan Li, Jia-Ying Liang, Hui Wang, Zhu Deng, Qiong Cao, Jia-Zheng
...
Published in
Journal of Translational Medicine
Background N6-methyladenosine (m6A) related long noncoding RNAs (lncRNAs) may have prognostic value in bladder cancer for their key role in tumorigenesis and innate immunity. Methods Bladder cancer transcriptome data and the corresponding clinical data were acquired from the Cancer Genome Atlas (TCGA) database. The m6A-immune-related lncRNAs were i...
Sharen, Gaowa Li, Xiongfeng Sun, Jiaxin Zhang, Lei Xi, Wen Zhao, Xiaodong Han, Fei Jia, Longlong A, Rong Cheng, Haidong
...
Published in
Journal of Translational Medicine
Background Colorectal cancer (CRC) is one of the most commonly diagnosed human malignancies. Ribosomal protein L31 (RPL31, aka eL31) is a component of the 60S large ribosomal subunit, and its expression pattern and functional role in CRC have not been reported. Methods Herein, we identified that eL31 protein level was dramatically increased in CRC ...
Wang, Yong-Bo Yang, Lan Deng, Yu-Qing Yan, Si-Yu Luo, Li-Sha Chen, Ping Zeng, Xian-Tao
Published in
Journal of Translational Medicine
Background Obesity (waist circumference, body mass index (BMI)) and lifestyle factors (dietary habits, smoking, alcohol drinking, Sedentary behavior) have been associated with risk of benign prostatic hyperplasia (BPH) in observational studies, but whether these associations are causal is unclear. Methods We performed a univariable and multivariabl...
Tahedl, Marlene Levine, Seth M. Weissert, Robert Kohl, Zacharias Lee, De-Hyung Linker, Ralf A. Schwarzbach, Jens V.
Published in
Journal of Translational Medicine
Background The development of permanent disability in multiple sclerosis (MS) is highly variable among patients, and the exact mechanisms that contribute to this disability remain unknown. Methods Following the idea that the brain has intrinsic network organization, we investigated changes of functional networks in MS patients to identify possible ...
Zhang, Yuan-Wei Cao, Mu-Min Li, Ying-Juan Chen, Xiang-Xu Yu, Qian Rui, Yun-Feng
Published in
Journal of Translational Medicine
Osteoporosis (OP) is a systemic bone disease characterized by the decreased bone mass and destruction of bone microstructure, which tends to result in the enhanced bone fragility and related fractures, as well as high disability rate and mortality. Exercise is one of the most common, reliable and cost-effective interventions for the prevention and ...
Wu, Zhengquan Lei, Ke Li, Huaizhi He, Jiali Shi, Enxian
Published in
Journal of Translational Medicine
Rationale The M2-like tumor-associated macrophages (TAMs) are independent prognostic factors in melanoma. Methods We performed weighted gene co-expression network analysis (WGCNA) to identify the module most correlated with M2-like TAMs. The Cancer Genome Atlas (TCGA) patients were classified into two clusters that differed based on prognosis and b...
Zhang, Zhilei Zhou, Ye Jia, Yuming Wang, Chao Zhang, Meng Xu, Zhuo
Published in
Journal of Translational Medicine
Background Exosomes are deemed to be an important tool of intercellular communicators in cancer cells. Our study investigated the role of PRR34 long non-coding RNA antisense RNA 1 (PRR34-AS1) in regulating exosome secretion in hepatocellular carcinoma (HCC) cells. Methods Quantitative real-time polymerase chain reaction (RT-qPCR) analyzed the expre...
Wang, Zheng Waldman, Michelle F Basavanhally, Tara J Jacobs, Aviva R Lopez, Gonzalo Perichon, Regis Y Ma, Johnny J Mackenzie, Elyse M Healy, James B Wang, Yixin
...
Published in
Journal of translational medicine
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating condition that can lead to severe impairment of physical, psychological, cognitive, social, and occupational functions. The cause of ME/CFS remains incompletely understood. There is no clinical diagnostic test for ME/CFS. Although many therapies have been used off-label t...
