2,5-Dimethyl-Celecoxib Inhibits Cell Cycle Progression and Induces Apoptosis in Human Leukemia Cells
...Published in Journal of Pharmacology and Experimental Therapeutics in Sep 01, 2015
Proatherogenic macrophage activities are targeted by the flavonoid quercetin.
Published in Journal of Pharmacology and Experimental Therapeutics in November 2012
Many studies have demonstrated that the flavonoid quercetin protects against cardiovascular disease (CVD) and related risk factors. Atherosclerosis, the underlying cause of CVD, is also attenuated by oral quercetin administration in animal models. Although macrophages are key players during fatty streak formation and plaque progression and aggravat...
Seizure protection by intrapulmonary delivery of propofol hemisuccinate.
Published in Journal of Pharmacology and Experimental Therapeutics in January 2011
The lung provides a portal of entry for drug delivery that could be used to administer anticonvulsant substances to prevent or abort seizures. Here, we demonstrate that intrapulmonary propofol hemisuccinate (PHS) rapidly confers seizure protection in various rodent chemoconvulsant models. Propofol is a powerful anticonvulsant substance at subanesth...
Seizure Protection by Intrapulmonary Delivery of Propofol Hemisuccinate
Published in Journal of Pharmacology and Experimental Therapeutics in Sep 24, 2010
The lung provides a portal of entry for drug delivery that could be used to administer anticonvulsant substances to prevent or abort seizures. Here, we demonstrate that intrapulmonary propofol hemisuccinate (PHS) rapidly confers seizure protection in various rodent chemoconvulsant models. Propofol is a powerful anticonvulsant substance at subanesth...
Dual Action of n-Butanol on Neuronal Nicotinic alpha 4beta 2 Acetylcholine Receptors
Published in Journal of Pharmacology and Experimental Therapeutics in Nov 25, 2002
Dual Action of n-Butanol on Neuronal Nicotinic alpha 4beta 2 Acetylcholine Receptors
Published in Journal of Pharmacology and Experimental Therapeutics in Nov 25, 2002
Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamin...
Published in Journal of Pharmacology and Experimental Therapeutics
2,5-Dimethoxy-4-substituted phenylisopropylamines and phenethylamines are 5-hydroxytryptamine (serotonin) (5-HT)2A/2C agonists. The former are partial to full agonists, whereas the latter are partial to weak agonists. However, most data come from studies analyzing phospholipase C (PLC)-mediated responses, although additional effectors [e.g., phosph...