Yovich, John L. Zaidi, Syeda Nguyen, Minh D. K. Hinchliffe, Peter M.
Published in
Journal of Personalized Medicine
This study examines the IGF serum profile (IGF-1, IGFBP-3 and the IGF Ratio) from 1633 women who undertook an Assessment Cycle prior to any treatment by assisted reproduction. The idea is to progressively study the IGF profile with a view to identify those women who may be classified as having adult growth hormone deficiency (AGHD) and who may bene...
Perez-Garcia, Javier Hernández-Pérez, José M. González-Pérez, Ruperto Sardón, Olaia Martin-Gonzalez, Elena Espuela-Ortiz, Antonio Mederos-Luis, Elena Callero, Ariel Herrera-Luis, Esther Corcuera, Paula
...
Published in
Journal of Personalized Medicine
Asthma exacerbations are a major contributor to the global disease burden, but no significant predictive biomarkers are known. The Genomics and Metagenomics of Asthma Severity (GEMAS) study aims to assess the role of genomics and the microbiome in severe asthma exacerbations. Here, we present the design of GEMAS and the characteristics of patients ...
Bremner, James Douglas Gurel, Nil Z. Wittbrodt, Matthew T. Shandhi, Mobashir H. Rapaport, Mark H. Nye, Jonathon A. Pearce, Bradley D. Vaccarino, Viola Shah, Amit J. Park, Jeanie
...
Published in
Journal of Personalized Medicine
Background: Vagal Nerve Stimulation (VNS) has been shown to be efficacious for the treatment of depression, but to date, VNS devices have required surgical implantation, which has limited widespread implementation. Methods: New noninvasive VNS (nVNS) devices have been developed which allow external stimulation of the vagus nerve, and their effects ...
Marcolin, Giuseppe Petrone, Nicola Benazzato, Michael Bettella, Francesco Gottardi, Angela Salmaso, Luigi Corain, Livio Musumeci, Alfredo Masiero, Stefano Paoli, Antonio
...
Published in
Journal of Personalized Medicine
In Paralympic sports, the goal of functional classifications is to minimize the impact of impairment on the outcome of the competition. The present cross-sectional study aimed to investigate aerobic and anaerobic personalized tests in Paralympic athletes and to correlate them with the classification of the international wheelchair rugby federation ...
AL-Eitan, Laith N. Almasri, Ayah Y. Khasawneh, Rame H. Alghamdi, Mansour A.
Published in
Journal of Personalized Medicine
The purpose of this study was to investigate the effects of the SH2B3 , MTHFD1L , GGCX , and ITGB3 gene variants on the efficacy of warfarin treatment and its effects on the risk of cardiovascular disorders in Jordanian patients. The selected genes and their polymorphisms are involved in many Genome-Wide Association Study (GWAS) associated with car...
d’Abramo, Cristina D’Adamio, Luciano Giliberto, Luca
Published in
Journal of Personalized Medicine
Alzheimer’s disease (AD) is the most common type of dementia, affecting more than 5 million Americans, with steadily increasing mortality and incredible socio-economic burden. Not only have therapeutic efforts so far failed to reach significant efficacy, but the real pathogenesis of the disease is still obscure. The current theories are based on pa...
Argentati, Chiara Tortorella, Ilaria Bazzucchi, Martina Emiliani, Carla Morena, Francesco Martino, Sabata
Published in
Journal of Personalized Medicine
Nowadays, the amyloid cascade hypothesis is the dominant model to explain Alzheimer’s disease (AD) pathogenesis. By this hypothesis, the inherited genetic form of AD is discriminated from the sporadic form of AD (SAD) that accounts for 85–90% of total patients. The cause of SAD is still unclear, but several studies have shed light on the involvemen...
Urbán, László Dóczi, Róbert Vodicska, Barbara Kormos, Dóra Tóth, László Takács, István Várkondi, Edit Tihanyi, Dóra Lakatos, Dóra Dirner, Anna
...
Published in
Journal of Personalized Medicine
Background: The anaplastic lymphoma kinase ( ALK ) gene fusion rearrangement is a potent oncogene, accounting for 2–7% of lung adenocarcinomas, with higher incidence (17–20%) in non-smokers. ALK -positive tumors are sensitive to ALK tyrosine kinase inhibitors (TKIs), thus ALK -positive non-small-cell lung cancer (NSCLC) is currently spearheading pr...
Hlaváč, Viktor Holý, Petr Souček, Pavel
Published in
Journal of Personalized Medicine
Pharmacogenomics is an evolving tool of precision medicine. Recently, due to the introduction of next-generation sequencing and projects generating “Big Data”, a plethora of new genetic variants in pharmacogenes have been discovered. Cancer resistance is a major complication often preventing successful anticancer treatments. Pharmacogenomics of bot...
Bossù, Paola Toppi, Elisa Sterbini, Valentina Spalletta, Gianfranco
Published in
Journal of Personalized Medicine
SARS-CoV-2, the virus responsible for the COVID-19 pandemic, leads to a respiratory syndrome and other manifestations. Most affected people show no or mild symptoms, but the risk of severe disease and death increases in older people. Here, we report a narrative review on selected studies targeting aging-related chronic neuroinflammation in the COVI...
