Rahma, Azhar T. Elbarazi, Iffat Ali, Bassam R. Patrinos, George P. Ahmed, Luai A. Al Maskari, Fatma
Published in
Journal of Personalized Medicine
(1) Background: Genomics and pharmacogenomics are relatively new fields in medicine in the United Arab Emirates (UAE). Understanding the knowledge, attitudes and current practices among pharmacists is an important pillar to establish the roadmap for implementing genomic medicine and pharmacogenomics; (2) Methods: A qualitative method was used, with...
Maruyama, Rika Yokota, Toshifumi
Published in
Journal of Personalized Medicine
With the development of novel targeted therapies, including exon skipping/inclusion and gene replacement therapy, the field of neuromuscular diseases has drastically changed in the last several years. Until 2016, there had been no FDA-approved drugs to treat Duchenne muscular dystrophy (DMD), the most common muscular dystrophy. However, several new...
Liu, Li-Wei Hsieh, Yao-Yu Yang, Pei-Ming
Published in
Journal of Personalized Medicine
Pancreatic ductal adenocarcinoma (PDAC) is still one of the most aggressive and lethal cancer types due to the late diagnosis, high metastatic potential, and drug resistance. The development of novel therapeutic strategies is urgently needed. KRAS (Kirsten rat sarcoma 2 viral oncogene homolog) is the major driver mutation gene for PDAC tumorigenesi...
Łasińska, Izabela Kolenda, Tomasz Guglas, Kacper Kopczyńska, Magda Sobocińska, Joanna Teresiak, Anna Strzelecki, Norbert Oksza Lamperska, Katarzyna Mackiewicz, Andrzej Mackiewicz, Jacek
...
Published in
Journal of Personalized Medicine
Background: Long non-coding RNA (lncRNA) are RNA molecules that are more than 200 nucleotides long and have the ability to modify the activity of genes. They can be found in both healthy and cancer tissues, as well as in plasma, saliva and other bodily fluids. They can also be used as biomarkers of early detection, prognosis and chemotherapy resist...
Le, Nguyen Quoc Khanh Do, Duyen Thi Chiu, Fang-Ying Yapp, Edward Kien Yee Yeh, Hui-Yuan Chen, Cheng-Yu
Published in
Journal of Personalized Medicine
Approximately 96% of patients with glioblastomas (GBM) have IDH1 wildtype GBMs, characterized by extremely poor prognosis, partly due to resistance to standard temozolomide treatment. O6-Methylguanine-DNA methyltransferase (MGMT) promoter methylation status is a crucial prognostic biomarker for alkylating chemotherapy resistance in patients with GB...
Lupean, Roxana-Adelina Ștefan, Paul-Andrei Feier, Diana Sorina Csutak, Csaba Ganeshan, Balaji Lebovici, Andrei Petresc, Bianca Mihu, Carmen Mihaela
Published in
Journal of Personalized Medicine
The imaging diagnosis of malignant ovarian cysts relies on their morphological features, which are not always specific to malignancy. The histological analysis of these cysts shows specific fluid characteristics, which cannot be assessed by conventional imaging techniques. This study investigates whether the texture-based radiomics analysis (TA) of...
Sioen, Simon Cloet, Karlien Vral, Anne Baeyens, Ans
Published in
Journal of Personalized Medicine
The cytokinesis-block micronucleus (CBMN) assay is a standardized method used for genotoxicity studies. Conventional whole blood cultures (WBC) are often used for this assay, although the assay can also be performed on isolated peripheral blood mononuclear cell (PBMC) cultures. However, the standardization of a protocol for the PBMC CBMN assay has ...
Toelle, Brett G. Marks, Guy B. Dunn, Stewart M.
Published in
Journal of Personalized Medicine
Medication non-adherence is associated with sub-optimal asthma control. Identification of medical and psychological characteristics associated with non-adherence is important to enable a targeted and personalized approach when working with patients and for the development of interventions to improve patient outcomes by improving medication adherenc...
Franko, Andras Berti, Lucia Hennenlotter, Jörg Rausch, Steffen Scharpf, Marcus O. de Angelis, Martin Hrabĕ Stenzl, Arnulf Birkenfeld, Andreas L. Peter, Andreas Lutz, Stefan Z.
...
Published in
Journal of Personalized Medicine
Aldo-keto reductase family 1 (AKR1) enzymes play a crucial role in diabetic complications. Since type 2 diabetes (T2D) is associated with cancer progression, we investigated the impact of diabetes on AKR1 gene expression in the context of prostate cancer (PCa) development. In this study, we analyzed benign (BEN) prostate and PCa tissue of patients ...
Keegan, Casey N. Johnston, Craig A. Cardenas, Victor J. Jr. Vaughan, Elizabeth M.
Published in
Journal of Personalized Medicine
Background: Diabetes is a major contributor to morbidity and mortality. Community Health Workers (CHWs) have been instrumental in improving patient outcomes. However, CHW training largely focuses on general diabetes concepts rather than medications. Providing accessible, diabetes medication training for CHWs has the potential to increase patient un...
