Malenge, Marion M. Patzke, Sebastian Ree, Anne H. Stokke, Trond Ceuppens, Peter Middleton, Brian Dahle, Jostein Repetto-Llamazares, Ada H.V.
Published in
Journal of Nuclear Medicine
Patients with non-Hodgkin lymphoma (NHL) who are treated with rituximab may develop resistant disease, often associated with changes in expression of CD20. The next-generation β-particle–emitting radioimmunoconjugate 177Lu-lilotomab-satetraxetan (Betalutin) was shown to up-regulate CD20 expression in different rituximab-sensitive NHL cell lines and...
Skali, Hicham Murthy, Venkatesh L. Paez, Diana Choi, Elisa M. Keng, Felix Y. J. Iain, McGhie A. Al-Mallah, Mouaz Campisi, Roxana Bateman, Timothy M. Carrio, Ignasi
...
Published in
Journal of Nuclear Medicine
Matesan, Manuela Fisher, Darrell R Wong, Roger Gopal, Ajay K Green, Damian J Sandmaier, Brenda M Bensinger, William Pagel, John M Orozco, Johnnie Press, Oliver W
...
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
We reviewed 111In-DOTA-anti-CD45 antibody (BC8) imaging and bone marrow biopsy measurements to ascertain the biodistribution and biokinetics of the radiolabeled antibody and to investigate differences based on type of hematologic malignancy. Methods: Serial whole-body scintigraphic images (4 time points) were obtained after infusion of the 111In-DO...
Shaffer, Travis M. Aalipour, Amin Schürch, Christian M. Gambhir, Sanjiv S.
Published in
Journal of Nuclear Medicine
Redirecting the immune system in cancer treatment has led to remarkable responses in a subset of patients. Natural killer (NK) cells are innate lymphoid cells being explored as they engage tumor cells in different mechanisms compared with T cells, which could be exploited for treatment of nonresponders to current immunotherapies. NK cell therapies ...
van der Veen, Elly L. Suurs, Frans V. Cleeren, Frederik Bormans, Guy Elsinga, Philip H. Hospers, Geke A.P. Lub-de Hooge, Marjolijn N. de Vries, Elisabeth G.E. de Vries, Erik F.J. Antunes, Inês F.
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Published in
Journal of Nuclear Medicine
Recently, N -(4-18F-fluorobenzoyl)-interleukin-2 (18F-FB-IL2) was introduced as a PET tracer for T cell imaging. However, production is complex and time-consuming. Therefore, we developed 2 radiolabeled IL2 variants, namely aluminum 18F-fluoride-(restrained complexing agent)-IL2 (18F-AlF-RESCA-IL2) and 68Ga-gallium-(1,4,7-triazacyclononane-4,7-diac...
Freudenberg, Lutz S. Paez, Diana Giammarile, Francesco Cerci, Juliano Modiselle, Moshe Pascual, Thomas N.B. El-Haj, Noura Orellana, Pilar Pynda, Yaroslav Carrió, Ignasi
...
Published in
Journal of Nuclear Medicine
The coronavirus disease 2019 (COVID-19) pandemic has placed significant challenges on health-care systems worldwide, whether in the preparation, response, or recovery phase of the pandemic. This has been primarily managed by dramatically reducing in- and outpatient services for other diseases and implementing infection prevention and control measur...
Li, Yun Rose Roach, Mack III
Published in
Journal of Nuclear Medicine
Lubberink, Mark Wilking, Helena Öst, Amalia Ilan, Ezgi Sandström, Mattias Andersson, Camilla Fröss-Baron, Katarzyna Velikyan, Irina Sundin, Anders
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Peptide receptor radiotherapy using 177Lu-labeled somatostatin ligand analogs is a well-established treatment for neuroendocrine tumors, with 177Lu-DOTATATE having acquired marketing authorization in Europe and the United States. The investigation of the pharmacokinetics of these radiopharmaceuticals in vivo in humans is crucial for personalized tr...
Henry, Kelly E Chaney, Aisling M Nagle, Veronica L Cropper, Haley C Mozaffari, Saghar Slaybaugh, Gregory Parang, Keykavous Andreev, Oleg A Reshetnyak, Yana K James, Michelle L
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Acidosis is a key driver for many diseases, including cancer, sepsis, and stroke. The spatiotemporal dynamics of dysregulated pH across disease remain elusive, and current diagnostic strategies do not provide localization of pH alterations. We sought to explore if PET imaging using hydrophobic cyclic peptides that partition into the cellular membra...
Liu, Chen Liu, Teli Zhang, Zhongyi Zhang, Ning Du, Peng Yang, Yong Liu, Yiqiang Yu, Wei Li, Nan Gorin, Michael A
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The purpose of this study was to investigate the feasibility and diagnostic efficacy of 68Ga-prostate-specific membrane antigen (PSMA) PET/CT combined with PET/ultrasound-guided biopsy in the diagnosis of prostate cancer (PCa). Methods: In total, 31 patients with a previously negative prostate biopsy but persistent elevated serum prostate-specific ...
