Parlani, Maria Boccalatte, Francesco Yeaton, Anna Wang, Feng Zhang, Jianhua Aifantis, Iannis Dondossola, Eleonora
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
223Ra is a bone-seeking, α-particle-emitting radionuclide approved for the treatment of patients with metastatic prostate cancer and is currently being tested in a variety of clinical trials for primary and metastatic cancers to bone. Clinical evaluation of 223Ra hematologic safety showed a significantly increased rate of neutropenia and thrombocyt...
Verhoeff, Sarah R van de Donk, Pim P Aarntzen, Erik H J G Oosting, Sjoukje F Brouwers, Adrienne H Miedema, Iris H C Voortman, Jens Menke-van der Houven van Oordt, Willemie... Boellaard, Ronald Vriens, Dennis
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
In this PD-L1 ImagiNg to prediCt durvalumab treatment response in SCCHN (PINCH) study, we performed 89Zr-DFO-durvalumab (anti-PD-L1 [programmed death ligand 1]) PET/CT in patients with recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) before monotherapy durvalumab treatment. The primary aims were to assess safety an...
Wei, Weijun Younis, Muhsin H Lan, Xiaoli Liu, Jianjun Cai, Weibo
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Single-domain antibody (sdAb) is among the most promising vectors for developing molecular imaging tracers. Several sdAb tracers targeting human epidermal growth factor receptor 2 or programmed death ligand 1 have entered clinical practice. However, radiolabeled single-valent sdAbs generally have high kidney retention, limiting their therapeutic ap...
Zanotti-Fregonara, Paolo Ishiguro, Tatsuya Yoshihara, Kosuke Ishii, Shiro Enomoto, Takayuki
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
The fetal absorbed dose from 18F-FDG administration to the mother is an essential piece of information when considering the use of PET to stage cancers during pregnancy. However, the few existing human case reports were obtained using either PET-only or PET/CT machines, which may not accurately identify the soft tissues of the fetus for dosimetric ...
Abdelhafez, Yasser Raychaudhuri, Siba P Mazza, Dario Sarkar, Soumajyoti Hunt, Heather L McBride, Kristin Nguyen, Mike Caudle, Denise T Spencer, Benjamin A Omidvari, Negar
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Autoimmune inflammatory arthritides (AIA), such as psoriatic arthritis and rheumatoid arthritis, are chronic systemic conditions that affect multiple joints of the body. Recently, total-body (TB) PET/CT scanners exhibiting superior technical characteristics (total-body coverage, geometric sensitivity) that could benefit AIA evaluation, compared wit...
Spangler-Bickell, Matthew G Hurley, Samuel A Pirasteh, Ali Perlman, Scott B Deller, Timothy McMillan, Alan B
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Head motion during brain PET imaging can significantly degrade the quality of the reconstructed image, leading to reduced diagnostic value and inaccurate quantitation. A fully data-driven motion correction approach was recently demonstrated to produce highly accurate motion estimates (
Bartos, Laura M Kunte, Sebastian T Beumers, Philipp Xiang, Xianyuan Wind, Karin Ziegler, Sibylle Bartenstein, Peter Choi, Hongyoon Lee, Dong Soo Haass, Christian
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
With great interest, our independent groups of scientists located in Korea and Germany recognized the use of a very similar methodologic approach to quantify the uptake of radioactive glucose (18F-FDG) at the cellular level. The focus of our investigations was to disentangle microglial 18F-FDG uptake. To do so, CD11b immunomagnetic cell sorting was...
Pomykala, Kelsey L Herrmann, Ken Padhani, Anwar R Hofman, Michael S Lalumera, Elisabetta Fanti, Stefano
Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Sathekge, Mike Bruchertseifer, Frank Vorster, Mariza Lawal, Ismaheel O Knoesen, Otto Mahapane, Johncy Davis, Cindy Mdlophane, Amanda Maes, Alex Mokoala, Kgomotso
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
225Ac-PSMA-617, targeting the prostate-specific membrane antigen (PSMA), which is overexpressed on prostate cancer cells, has shown a remarkable therapeutic efficacy in heavily pretreated patients with metastatic castration-resistant prostate carcinoma (mCRPC). Here, we report on treatment outcome and survival using this novel treatment modality in...
Signore, Alberto Campagna, Giuseppe Marinaccio, Jessica Vitis, Marco de Lauri, Chiara Berardinelli, Francesco Tofani, Anna Chianelli, Marco Borro, Marina Gentile, Giovanna
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Published in
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
It is well known that ionizing radiation can induce genetic damage and that oxidative stress is a major factor inducing it. Our aim was to investigate whether thyroid remnant ablation with low activities of 131I (1,850 MBq) is associated with DNA damage by evaluating the CometAssay, micronuclei, and chromosome aberrations with multicolor fluorescen...
