Clé, Marion Constant, Orianne Barthelemy, Jonathan Desmetz, Caroline Martin, Marie France Lapeyre, Lina Cadar, Daniel Savini, Giovanni Teodori, Liana Monaco, Federica
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Published in
Journal of Neuroinflammation
BackgroundUsutu virus (USUV) is an emerging neurotropic arthropod-borne virus recently involved in massive die offs of wild birds predominantly reported in Europe. Although primarily asymptomatic or presenting mild clinical signs, humans infected by USUV can develop neuroinvasive pathologies (including encephalitis and meningoencephalitis). Similar...
Fleischer, Michael Lee, Inn Erdlenbruch, Friedrich Hinrichs, Lena Petropoulos, Ioannis N. Malik, Rayaz A. Hartung, Hans-Peter Kieseier, Bernd C. Kleinschnitz, Christoph Stettner, Mark
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Published in
Journal of Neuroinflammation
BackgroundImmune-mediated neuropathies, such as chronic inflammatory demyelinating polyneuropathy (CIDP) are treatable neuropathies. Among individuals with diabetic neuropathy, it remains a challenge to identify those individuals who develop CIDP. Corneal confocal microscopy (CCM) has been shown to detect corneal nerve fiber loss and cellular infil...
Rabaneda-Lombarte, Neus Serratosa, Joan Bové, Jordi Vila, Miquel Saura, Josep Solà, Carme
Published in
Journal of Neuroinflammation
BackgroundIt is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson’s disease (PD). Consequently, the modulation of microglial activation is a potential therapeutic target to be taken into account to act against the dopaminergic neurodegeneration occurring in this n...
Suzuki, Kaoru Shinohara, Mitsuru Uno, Yoshihiro Tashiro, Yoshitaka Gheni, Ghupurjan Yamamoto, Miho Fukumori, Akio Shindo, Akihiko Mashimo, Tomoji Tomimoto, Hidekazu
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Published in
Journal of Neuroinflammation
BackgroundSubcortical ischemic vascular dementia, one of the major subtypes of vascular dementia, is characterized by lacunar infarcts and white matter lesions caused by chronic cerebral hypoperfusion. In this study, we used a mouse model of bilateral common carotid artery stenosis (BCAS) to investigate the role of B-cell translocation gene 2 (BTG2...
Pelisch, Nicolas Almanza, Jose Rosas Stehlik, Kyle E. Aperi, Brandy V. Kroner, Antje
Published in
Journal of Neuroinflammation
An amendment to this paper has been published and can be accessed via the original article.
Zheng, You Zhang, Yan-Min Tang, Zheng-Shan Du, Jian-Kui Guo, De-Wei Xu, Yong-Jun Sheng, Hui Lu, Jian-Qiang Ni, Xin
Published in
Journal of Neuroinflammation
BackgroundPrenatal synthetic glucocorticoid (sGC) exposure increases the susceptibility to cognitive and affective disorders in postnatal life. We previously demonstrated that prenatal sGC exposure results in an increase in corticotropin-releasing hormone (CRH) receptor type 1 (CRHR1) expression in the hippocampus of rats, and CRHR1 is involved in ...
Chen, Ruixiang Yin, Chengyu Fang, Jianqiao Liu, Boyi
Published in
Journal of Neuroinflammation
Chronic pain affects the life quality of the suffering patients and posts heavy problems to the health care system. Conventional medications are usually insufficient for chronic pain management and oftentimes results in many adverse effects. The NLRP3 inflammasome controls the processing of proinflammatory cytokine interleukin 1β (IL-1β) and is imp...
van Wageningen, Thecla A. Antonovaite, Nelda Paardekam, Erik Brevé, John J. P. Iannuzzi, Davide van Dam, Anne-Marie
Published in
Journal of Neuroinflammation
BackgroundThe biomechanical properties of the brain have increasingly been shown to relate to brain pathology in neurological diseases, including multiple sclerosis (MS). Inflammation and demyelination in MS induce significant changes in brain stiffness which can be linked to the relative abundance of glial cells in lesions. We hypothesize that the...
Lim, Erin-Mai F. Hoghooghi, Vahid Hagen, Kathleen M. Kapoor, Kunal Frederick, Ariana Finlay, Trisha M. Ousman, Shalina S.
Published in
Journal of Neuroinflammation
BackgroundInflammation constitutes both positive and negative aspects to recovery following peripheral nerve injury. Following damage to the peripheral nervous system (PNS), immune cells such as macrophages play a beneficial role in creating a supportive environment for regrowing axons by phagocytosing myelin and axonal debris. However, a prolonged...
Dansereau, Marc-André Midavaine, Élora Bégin-Lavallée, Valérie Belkouch, Mounir Beaudet, Nicolas Longpré, Jean-Michel Mélik-Parsadaniantz, Stéphane Sarret, Philippe
Published in
Journal of Neuroinflammation
BackgroundPain is reported as the leading cause of disability in the common forms of inflammatory arthritis conditions. Acting as a key player in nociceptive processing, neuroinflammation, and neuron-glia communication, the chemokine CCL2/CCR2 axis holds great promise for controlling chronic painful arthritis. Here, we investigated how the CCL2/CCR...