Fares, Mazigh Cochet-Bernoin, Marielle Gonzalez, Gaëlle Montero-Menei, Claudia N. Blanchet, Odile Benchoua, Alexandra Boissart, Claire Lecollinet, Sylvie Richardson, Jennifer Haddad, Nadia
...
Published in
Journal of Neuroinflammation
BackgroundTick-borne encephalitis virus (TBEV) is a member of the Flaviviridae family, Flavivirus genus, which includes several important human pathogens. It is responsible for neurological symptoms that may cause permanent disability or death, and, from a medical point of view, is the major arbovirus in Central/Northern Europe and North-Eastern As...
Wang, Yaping Shi, Yu Huang, Yongquan Liu, Wei Cai, Guiyuan Huang, Shimin Zeng, Yanyan Ren, Siqiang Zhan, Hongrui Wu, Wen
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Published in
Journal of Neuroinflammation
Background Neuropathic pain (NeuP) is a chronic and challenging clinical problem, with little effective treatment. Resveratrol has shown neuroprotection by inhibiting inflammatory response in NeuP. Recently, the triggering receptor expressed on myeloid cells 2 (TREM2) expressed by microglia was identified as a critical factor of inflammation in ner...
Zilkha-Falb, Rina Rachutin-Zalogin, Tatyana Cleaver, Lakota Gurevich, Michael Achiron, Anat
Published in
Journal of Neuroinflammation
Background Targeting RNA polymerase-1 (POL1) machinery is a new strategy for suppression of multiple sclerosis (MS) relapse activity. Oral administration of POL1 inhibitor RAM-589.555, which is characterized by high permeability and bioavailability in naïve mice, ameliorates proteolipid protein (PLP)-induced experimental autoimmune encephalomyeliti...
Kanno, Kohei Shimizu, Kohei Shinoda, Masamichi Hayashi, Makoto Takeichi, Osamu Iwata, Koichi
Published in
Journal of Neuroinflammation
Background The existence of referred pain and ectopic paresthesia caused by tooth pulp inflammation may make definitive diagnosis difficult and cause misdiagnosis or mistreatment; thus, elucidation of that molecular mechanism is urgent. In the present study, we investigated the mechanisms underlying ectopic pain, especially tongue hyperalgesia, aft...
Wang, Chunyue Cai, Xueying Wang, Ruochen Zhai, Siyu Zhang, Yongfeng Hu, Wenji Zhang, Yizhi Wang, Di
Published in
Journal of Neuroinflammation
BackgroundEndoplasmic reticulum (ER) stress is involved in the progression of Alzheimer’s disease (AD). Verbascoside (VB), an active phenylethanoid glycoside that was first isolated from Verbascum sinuatum (the wavyleaf mullein), possesses anti-inflammatory, antioxidative, and anti-apoptotic effects. The purpose of this study was to elucidate the b...
Liu, Meng Zhang, Su-Bo Luo, Yu-Xuan Yang, Yan-Ling Zhang, Xiang-Zhong Li, Bo Meng, Yan Chen, Yuan-Jie Guo, Rui-Xian Xiong, Yuan-Chang
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Published in
Journal of Neuroinflammation
BackgroundThe major dose-limiting toxicity of paclitaxel, one of the most commonly used drugs to treat solid tumor, is painful neuropathy. However, the molecular mechanisms underlying paclitaxel-induced painful neuropathy are largely unclarified.MethodsPaw withdrawal threshold was measured in the rats following intraperitoneal injection of paclitax...
Jin, Young-Hee Kang, Bongsu Kang, Hyun S. Koh, Chang-Sung Kim, Byung S.
Published in
Journal of Neuroinflammation
BackgroundExperimental autoimmune encephalitis (EAE) and virally induced demyelinating disease are two major experimental model systems used to study human multiple sclerosis. Although endothelin-1 level elevation was previously observed in the CNS of mice with EAE and viral demyelinating disease, the potential role of endothelin-1 in the developme...
Huang, Kuo-Lun Hsiao, Ing-Tsung Ho, Meng-Yang Hsu, Jung-Lung Chang, Yeu-Jhy Chang, Ting-Yu Liu, Chi-Hung Chang, Chien-Hung Wu, Yi-Ming Wu, Kuan-Yi
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Published in
Journal of Neuroinflammation
BackgroundThe aim of this study is to investigate the associations between post-stroke cognitive impairment (PSCI) severity and reactive astrogliosis (RA) extent on normalized 18F-THK-5351 positron-emission tomography (PET) imaging in amyloid-negative patients with first-ever stroke.MethodsWe prospectively enrolled 63 amyloid-negative patients with...
Sanchis, Paula Fernández-Gayol, Olaya Comes, Gemma Aguilar, Kevin Escrig, Anna Giralt, Mercedes Palmiter, Richard D. Hidalgo, Juan
Published in
Journal of Neuroinflammation
BackgroundInterleukin-6 (IL-6) is a pleiotropic cytokine that controls numerous physiological processes both in basal and neuroinflammatory conditions, including the inflammatory response to experimental autoimmune encephalomyelitis (EAE). IL-6 is produced by multiple peripheral and central cells, and until now, the putative roles of IL-6 from diff...
Kong, Fan’ge Jiang, Xue Wang, Ruochen Zhai, Siyu Zhang, Yizhi Wang, Di
Published in
Journal of Neuroinflammation
BackgroundNeuroinflammation is a principal element in Alzheimer’s disease (AD) pathogenesis, so anti-inflammation may be a promising therapeutic strategy. Forsythoside B (FTS•B), a phenylethanoid glycoside isolated from Forsythiae fructus, has been reported to exert anti-inflammatory effects. However, no studies have reported whether the anti-infla...
