Stefkó, Dóra Kúsz, Norbert Barta, Anita Kele, Zoltán Bakacsy, László Szepesi, Ágnes Fazakas, Csilla Wilhelm, Imola Krizbai, István A. Hohmann, Judit
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Published in
Journal of Natural Products
Species in the Juncaceae accumulate different types of secondary metabolites, among them phenanthrenes and 9,10-dihydrophenanthrenes in substantial amounts. These compounds have chemotaxonomic significance and also possess interesting pharmacological activities. The present study has focused on the isolation, structure determination, and pharmacolo...
Zandi, Linda Makungu, Marco Munissi, Joan J. E. Duffy, Sandra Puttreddy, Rakesh von der Heiden, Daniel Rissanen, Kari Avery, Vicky M. Nyandoro, Stephen S. Erdélyi, Máté
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The new 2,3-secoiridoids morisecoiridoic acids A (1) and B (2), the new iridoid 8-acetoxyepishanzilactone (3), and four additional known iridoids (4-7) were isolated from the leaf and stem bark methanol extracts of Morinda asteroscepa using chromatographic methods. The structure of shanzilactone (4) was revised. The purified metabolites were identi...
Atilaw, Yoseph Muiva-Mutisya, Lois Bogaerts, Jonathan Duffy, Sandra Valkonen, Arto Heydenreich, Matthias Avery, Vicky M. Rissanen, Kari Erdélyi, Máté Yenesew, Abiy
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Five new compounds-rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)-along with 16 known secondary metabolites, were isolated from the CH2Cl2-CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic a...
Alilou, Mostafa Marzocco, Stefania Hofer, David Rapa, Shara Francesca Asadpour, Rahman Schwaiger, Stefan Troppmair, Jakob Stuppner, Hermann
Published in
Journal of Natural Products
Phytochemical investigations of an extract of the aerial parts of Rydingia persica led to the isolation of 14 labdane-type diterpenoids, of which compounds 1 – 5 , 8 , and 12 – 14 turned out to be new natural products, while the remaining compounds were isolated for the first time from the genus Rydingia . Their structures were elucidated using 1D-...
Bekiesch, Paulina Zehl, Martin Domingo-Contreras, Elizabeth Martín, Jesús Pérez-Victoria, Ignacio Reyes, Fernando Kaplan, Arthur Rückert, Christian Busche, Tobias Kalinowski, Jörn
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Published in
Journal of Natural Products
Extracts from Streptomyces sp. S4.7 isolated from the rhizosphere of edelweiss, an alpine medicinal plant, exhibited activity against Gram-positive bacteria. LC-HRMS analyses of the extracts resulted in the detection of two unknown, structurally related lipopeptides that were assumed to be responsible for the antibiotic activity. LC-MS guided isola...
Tungen, Jørn Eivind Primdahl, Karoline Gangestad Hansen, Trond Vidar
Published in
Journal of Natural Products
The resolution of inflammation is governed by the active biosynthesis of specialized pro-resolving mediators using ω-6 and ω-3 polyunsaturated fatty acids as substrates. These mediators act as resolution agonists and display several interesting bioactivities. PD2n-3 DPA is an oxygenated polyunsaturated fatty acid biosynthesized from n-3 docosapenta...
Resetar, Mirta Liu, Xin Herdlinger, Sonja Kunert, Olaf Pferschy-Wenzig, Eva-Maria Latkolik, Simone Steinacher, Theresa Schuster, Daniela Bauer, Rudolf Dirsch, Verena M
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Published in
Journal of natural products
Oplopanax horridus and Panax ginseng are members of the plant family Araliaceae, which is rich in structurally diverse polyacetylenes. In this work, we isolated and determined structures of 23 aliphatic C17 and C18 polyacetylenes, of which five are new compounds. Polyacetylenes have a suitable scaffold for binding to PPARγ, a ligand-activated trans...
Alilou, Mostafa Dibwe, Dya Fita Schwaiger, Stefan Khodami, Mojtaba Troppmair, Jakob Awale, Suresh Stuppner, Hermann
Published in
Journal of natural products
Human pancreatic cancer is one of the most aggressive types of cancer, with a high mortality rate. Due to the high tolerance of such cancer cells to nutrient starvation conditions, they can survive in a hypovascular tumor microenvironment. In this study, the dichloromethane extract of the roots of Ferula hezarlalehzarica showed potent preferential ...
Robertson, Luke P. Moodie, Lindon W. K. Holland, Darren C. Jandér, K. Charlotte Göransson, Ulf
The structure of 2,4-(4'-aminobenzenamine)pyrimidine (1), a pyrimidine alkaloid previously isolated from the bulbs of Scilla madeirensis (Asparagaceae, synonym Autonoe madeirensis), has been revised. These conclusions were met via comparison of reported NMR and EIMS data with those obtained from synthetic standards. The corrected structure is the a...
Tranter, Dale Filipuzzi, Ireos Lochmann, Thomas Knapp, Britta Kellosalo, Juho Estoppey, David Pistorius, Dominik Meissner, Axel Paavilainen, Ville O. Hoepfner, Dominic
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Published in
Journal of Natural Products
Kendomycin is a small-molecule natural product that has gained significant attention due to reported cytotoxicity against pathogenic bacteria and fungi as well as a number of cancer cell lines. Despite significant biomedical interest and attempts to reveal its mechanism of action, the cellular target of kendomycin remains disputed. Herein it is sho...
