Botchkarev, Vladimir A Gdula, Michal R Mardaryev, Andrei N Sharov, Andrei A Fessing, Michael Y
Published in
The Journal of investigative dermatology
The nucleus is a complex and highly compartmentalized organelle, which undergoes major organization changes during cell differentiation, allowing cells to become specialized and fulfill their functions. During terminal differentiation of the epidermal keratinocytes, the nucleus undergoes a programmed transformation from active status, associated wi...
Swope, Viki B Jameson, Joshua A McFarland, Kevin L Supp, Dorothy M Miller, William E McGraw, Dennis W Patel, Mira A Nix, Matthew A Millhauser, Glenn L Babcock, George F
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Published in
The Journal of investigative dermatology
The melanocortin 1 receptor (MC1R), a G(s) protein-coupled receptor, has an important role in human pigmentation. We investigated the regulation of expression and activity of the MC1R in primary human melanocyte cultures. Human β-defensin 3 (HBD3) acted as an antagonist for MC1R, inhibiting the α-melanocortin (α-melanocyte-stimulating hormone (α-MS...
Mr, Dasu Rivkah Isseroff
Published in
Journal of Investigative Dermatology
Toll-like receptors (TLRs) are considered to be the first responders in the defense against invading pathogens. TLR engagement by ligands triggers inflammatory responses in injury and trauma, and thus can impair or contribute to the healing process, depending on TLRs expression pattern, cellular localization, signaling, and deployment of inflammat...
Carmona-Rivera, Carmelo Golas, Gretchen Hess, Richard A Cardillo, Nicholas D Martin, Elijah H O'Brien, Kevin Tsilou, Ekaterini Gochuico, Bernadette R White, James G Huizing, Marjan
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Published in
The Journal of investigative dermatology
Hermansky-Pudlak syndrome (HPS) is an autosomal recessive condition characterized by a bleeding diathesis and hypopigmentation of the skin, hair, and eyes. Some HPS patients develop other complications such as granulomatous colitis and/or fatal pulmonary fibrosis. Eight genes have been associated with this condition, resulting in subtypes HPS-1 thr...
Cullinane, Andrew R Vilboux, Thierry O'Brien, Kevin Curry, James A Maynard, Dawn M Carlson-Donohoe, Hannah Ciccone, Carla Markello, Thomas C Gunay-Aygun, Meral Huizing, Marjan
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Published in
The Journal of investigative dermatology
We evaluated a 32-year-old woman whose oculocutaneous albinism (OCA), bleeding diathesis, neutropenia, and history of recurrent infections prompted consideration of the diagnosis of Hermansky-Pudlak syndrome type 2. This was ruled out because of the presence of platelet δ-granules and absence of AP3B1 mutations. As parental consanguinity suggested ...
Fontao, Lionel Laffitte, Emmanuel Briot, Anais Kaya, Gürkan Roux-Lombard, Pascale Fraitag, Sylvie Alain Hovnanian Saurat, Jean-Hilaire
Published in
Journal of Investigative Dermatology
Cianfarani F Gabriele Toietta Di Rocco G Cesareo E Capogrossi MC Zambruno G Odorisio T
Published in
Journal of Investigative Dermatology
Kim, Min-Ho Liu, Wei Borjesson, Dori L Curry, Fitz-Roy E Miller, Lloyd S Cheung, Ambrose L Liu, Fu-Tong Isseroff, R Rivkah Simon, Scott I
Published in
The Journal of investigative dermatology
Neutrophil influx is an early inflammatory response that is essential for the clearance of bacteria and cellular debris during cutaneous wounding. A non-invasive real-time fluorescence imaging technique was developed to examine the kinetics of enhanced green fluorescence protein-polymorphonuclear leukocyte (EGFP-PMN) influx within a wound. We hypot...
Pellet, Claire Kerob, Delphine Dupuy, Alain Carmagnat, Mary V Mourah, Samia Podgorniak, Marie-Pierre Toledano, Cecile Morel, Patrice Vérola, Olivier Christine Dosquet
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Published in
Journal of Investigative Dermatology
In order to gain further insight on the role of Kaposi's sarcoma-associated herpesvirus (KSHV) in classic and endemic Kaposi's sarcoma (KS) pathogenesis, we aimed to determine (i) whether KSHV is detectable in peripheral blood mononuclear cells (PBMCs), (ii) which PBMCs subpopulation harbor the virus, (iii) which clinical, histologic, and immunolog...
Guo, A Song, B Brian Reid Gu, Y Forrester, Jv Jahoda, Ca Min Zhao
Published in
Journal of Investigative Dermatology
Endogenous electric currents generated instantly at skin wounds direct migration of epithelial cells and are likely to be important in wound healing. Migration of fibroblasts is critical in wound healing. It remains unclear how wound electric fields guide migration of dermal fibroblasts. We report here that mouse skin wounds generated endogenous el...