Okusaka, Takuji Furuse, Junji
Published in
Journal of Gastroenterology
The prognosis of patients with pancreatic cancer continues to remain dismal, even though numerous trials have been conducted to establish more effective therapies in Japan and throughout the world. Recent advances in treatment have been characterized by the use of novel combinations of conventional cytotoxic chemotherapies. Especially in Japan, S-1...
Mishima, Yoshiyuki Sartor, Ryan Balfour
Published in
Journal of gastroenterology
Altered intestinal microbial composition (dysbiosis) and metabolic products activate aggressive mucosal immune responses that mediate inflammatory bowel diseases (IBD). This dysbiosis impairs the function of regulatory immune cells, which normally promote mucosal homeostasis. Normalizing and maintaining regulatory immune cell function by correcting...
Hu, Haiming Lin, Aizhen Kong, Mingwang Yao, Xiaowei Yin, Mingzhu Xia, Hui Ma, Jun Liu, Hongtao
Published in
Journal of Gastroenterology
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of dysregulated lipid and glucose metabolism, which is often associated with obesity, dyslipidemia and insulin resistance. In view of the high morbidity and health risks of NAFLD, the lack of effective cure has drawn great attention. In recent years, a line of evidence has sugge...
Brusselaers, Nele Sadr-Azodi, Omid Engstrand, Lars
Published in
Journal of gastroenterology
The long-term safety of proton pump inhibitors (PPIs) is increasingly questioned. The aim of our study was to assess the risk of pancreatic cancer among long-term PPI users in Sweden. This population-based nationwide Swedish cohort study including 796,492 adult long-term PPI users has been used to calculate the standardized incidence rate ratios (S...
Yamashita, Tatsuya Kudo, Masatoshi Ikeda, Kenji Izumi, Namiki Tateishi, Ryosuke Ikeda, Masafumi Aikata, Hiroshi Kawaguchi, Yasunori Wada, Yoshiyuki Numata, Kazushi
...
Published in
Journal of gastroenterology
A phase 3, multinational, randomized, non-inferiority trial (REFLECT) compared the efficacy and safety of lenvatinib (LEN) and sorafenib (SOR) in patients with unresectable hepatocellular carcinoma (uHCC). LEN had an effect on overall survival (OS) compared to SOR, statistically confirmed by non-inferiority [OS: median = 13.6 months vs. 12.3 months...
Hirai, Fumihito Takeda, Teruyuki Takada, Yasumichi Kishi, Masahiro Beppu, Tsuyoshi Takatsu, Noritaka Miyaoka, Masaki Hisabe, Takashi Yao, Kenshi Ueki, Tosiharu
...
Published in
Journal of gastroenterology
Enteral nutrition (EN) is effective in Crohn's disease (CD) patients and has been shown to have an inhibitory effect on loss of response to anti-tumor necrosis factor (TNF)-alpha antibody therapy; however, the current level of evidence is not sufficient. The objective of this meta-analysis was to determine whether EN in combination anti-TNF-alpha a...
Higashiyama, Masaaki Sugita, Akira Koganei, Kazutaka Wanatabe, Kenji Yokoyama, Yoko Uchino, Motoi Nagahori, Masakazu Naganuma, Makoto Bamba, Shigeki Kato, Shingo
...
Published in
Journal of gastroenterology
Management of elderly ulcerative colitis in Japan.
Masuda, Kazuhiko Urabe, Yuji Ito, Masanori Ono, Atsushi Clair Nelson, Hayes Nakamura, Koki Kotachi, Takahiro Boda, Tomoyuki Tanaka, Shinji Chayama, Kazuaki
...
Published in
Journal of Gastroenterology
BackgroundGastric cancer may develop after successful eradication of Helicobacter pylori, although the incidence is lower than in non-eradicated individuals. We previously reported the appearance of characteristic epithelium with low-grade atypia (ELA) on the surface of gastric cancer after H. pylori eradication. However, whether ELA originates fro...
Spechler, Stuart Jon
Published in
Journal of gastroenterology
This report explores two hypotheses regarding eosinophilic esophagitis (EoE): (1) that the use of proton pump inhibitors (PPIs) might contribute to the pathogenesis of EoE by preventing peptic digestion of food allergens, by increasing gastric mucosal permeability to enable gastric absorption of those undegraded food allergens, and by causing micro...
Ebadi, Maryam Bhanji, Rahima A Mazurak, Vera C Montano-Loza, Aldo J
Published in
Journal of gastroenterology
Sarcopenia (severe muscle depletion) is a prevalent muscle abnormality in patients with cirrhosis that confers poor prognosis both pre- and post-liver transplantation. The pathogenesis of sarcopenia is multifactorial and results from an imbalance between protein synthesis and breakdown. Nutritional, metabolic, and biochemical abnormalities seen in ...
