Shirai, M Watanabe, S Nishioka, M
Published in
Journal of gastroenterology and hepatology
The effects of OK-432 (streptococcal preparation) on murine fulminant hepatitis were investigated. Hepatitis was induced by injection of mouse hepatitis virus type 2 (MHV-2) at a strength of either 1 x 10(3) or 1 x 10(4) plaque-forming units (PFU). Mice without OK-432 treatment died within 5 days, whereas mice preinoculated with OK-432 showed survi...
Kwan, Ambrose Chi-Pong Chau, Tai-Nin Tong, Wing-Lok Tsang, Owen Tak-Yin Tso, Eugene Yuk-Keung Chiu, Ming-Chi Yu, Wai-Cho Lai, Thomas Sik-To
Published in
Journal of gastroenterology and hepatology
Severe acute respiratory syndrome (SARS) is an emerging infectious disease and diarrhea has been reported in up to 76% of cases. The purpose of the present paper was to carry out a retrospective study of the clinical and demographic data of SARS patients with diarrhea in Princess Margaret Hospital. From 1 to 31 March 2003, hospital records from 240...
Huang, Wu-Shiung Chen, Rong-Fu Yang, Kuender D
Published in
Journal of gastroenterology and hepatology
Sakamoto, Naoya Tanabe, Yoko Yokota, Takanori Satoh, Kenichi Sekine-Osajima, Yuko Nakagawa, Mina Itsui, Yasuhiro Tasaka, Megumi Sakurai, Yuki Cheng-Hsin, Chen
...
Published in
Journal of gastroenterology and hepatology
We have reported previously that synthetic small interfering RNA (siRNA) and DNA-based siRNA expression vectors efficiently and specifically suppress hepatitis C virus (HCV) replication in vitro. In this study, we investigated the effects of the siRNA targeting HCV-RNA in vivo. We constructed recombinant retrovirus and adenovirus expressing short h...
Lubel, John S Herath, Chandana B Burrell, Louise M Angus, Peter W
Published in
Journal of gastroenterology and hepatology
The renin-angiotensin system (RAS) is a key regulator of vascular resistance, sodium and water homeostasis and the response to tissue injury. Historically, angiotensin II (Ang II) was thought to be the primary effector peptide of this system. Ang II is produced predominantly by the effect of angiotensin converting enzyme (ACE) on angiotensin I (Ang...
El Awady, Mostafa K Anany, Mohamed A Esmat, Gamal Zayed, Naglaa Tabll, Ashraf A Helmy, Amr El Zayady, Abdel Rahman Abdalla, Mohga S Sharada, Hayat M El Raziky, Maissa
...
Published in
Journal of gastroenterology and hepatology
Response to interferon therapy and disease progression in hepatitis C virus (HCV) infected patients differs among individuals, suggesting a possibility of a contribution of host genetic factors. 2'-5'-oligoadenylate synthetase 1 (OAS1), an important component of the innate immune system with a proven antiviral function, may therefore have a relatio...
Sim, Winnie H Wagner, Josef Cameron, Donald J Catto-Smith, Anthony G Bishop, Ruth F Kirkwood, Carl D
Published in
Journal of gastroenterology and hepatology
Expression profiling of genes specific to pediatric Crohn's Disease (CD) patients was performed to elucidate the molecular mechanisms underlying disease cause and pathogenesis at disease onset. We used suppressive subtractive hybridization (SSH) and differential screening analysis to profile the mRNA expression patterns of children with CD and age-...
Patrick Marcellin Tarik Asselah
Published in
Journal of Gastroenterology and Hepatology
Since the licensing of the first treatment for chronic hepatitis B in the nucleoside/tide analog class almost 15 years ago, considerable progress has been made in improving drug efficacy and safety with highly potent nucleoside/tide analogs exhibiting a high barrier to resistance. Physicians are now able to treat patients safely for many years and ...
