Prevalence and impact of diabetes among people infected with SARS-CoV-2
Published in Journal of Endocrinological Investigation
The treatment with pasireotide in Cushing's disease: effect of long-term treatment on clinical picture and metabolic pro...
...Published in Journal of endocrinological investigation
Pasireotide is the first medical therapy officially approved for adult patients with Cushing's disease (CD) experiencing failure of pituitary surgery or not candidates for surgery. The current study aimed at investigating pasireotide effects on clinical picture and metabolic profile in patients enrolled in the phase III CSOM230B2305 trial at Naples...
Climacteric symptoms are related to thyroid status in euthyroid menopausal women.
Published in Journal of endocrinological investigation
Climacteric symptoms are a variety of disturbing complaints occurring during menopausal transition, many of which may be influenced by hormonal abnormalities other than related to sex steroids. In this study, we investigated the association between the intensity of climacteric symptoms measured with the Kupperman index and a thyroid status. We eval...
Micronutrients in support to the one carbon cycle for the modulation of blood fasting homocysteine in PCOS women
...Published in Journal of Endocrinological Investigation
Purpose Fasting blood homocysteine is increased in PCOS women and is involved in several of its co-morbidities including cardiovascular disease and infertility. Corrective interventions based on the administration of supra-physiologic doses of folic acid work to a low extent. We aimed to test an alternative approach. Methods This was a prospective,...
Association between biochemical control and comorbidities in patients with acromegaly: an Italian longitudinal retrospec...
...Published in Journal of Endocrinological Investigation
Purpose Achieving biochemical control (normalization of insulin-like growth factor-1 [IGF-1] and growth hormone [GH]) is a key goal in acromegaly management. However, IGF-1 and GH fluctuate over time. The true potential impact of time-varying biochemical control status on comorbidities is unclear and relies on multiple, longitudinal IGF-1 and GH me...
l -Carnitine counteracts in vitro fructose-induced hepatic steatosis through targeting oxidative stress markers
Published in Journal of Endocrinological Investigation
Purpose Nonalcoholic fatty liver disease (NAFLD) is defined by excessive lipid accumulation in the liver and involves an ample spectrum of liver diseases, ranging from simple uncomplicated steatosis to cirrhosis and hepatocellular carcinoma. Accumulating evidence demonstrates that high fructose intake enhances NAFLD development and progression prom...
Parathyroid hormone reference ranges in healthy individuals classified by vitamin D status.
Published in Journal of endocrinological investigation
Parathyroid hormone (PTH) concentrations are routinely measured in the diagnosis and management of bone and kidney diseases, but reference ranges can be overestimated if determined in otherwise healthy individuals for whom vitamin D deficiency was not evaluated. We establish PTH reference ranges in apparently healthy, normocalcemic, normophosphatem...
Thyroid nodules with Hürthle cells: the malignancy risk in relation to the FNA outcome category.
...Published in Journal of endocrinological investigation
The aim was to find whether the presence of Hürthle cells (HC) in a smear influences the categorization of FNA results or the risk of malignancy (RoM) of particular categories of cytological diagnosis. 25,220 FNA performed in a single center in years 2005-2017 were analyzed. Almost all the examined patients were exposed to moderate iodine deficienc...
The effect of previous treatment with bisphosphonate and renal impairment on the response to denosumab in osteoporosis: ...
Published in Journal of Endocrinological Investigation
Purpose To investigate changes in bone mineral density (BMD) following denosumab after previous bisphosphonate therapy and the impact of chronic kidney disease (CKD) on response. Methods A retrospective study of 134 patients (11 M, 123 F) aged [mean (SD)] 72 [11] years on denosumab was undertaken. Ninety-five patients had previously been on oral an...
Clinical, hormonal and metabolic parameters in women with PCOS with different combined oral contraceptives (containing c...
Published in Journal of Endocrinological Investigation
Introduction Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting 5–10% of women of reproductive age. It is characterized by chronic anovulation leading to menstrual disorders, and increased infertility. The syndrome can also manifest as hirsutism and acne. Aim of the study The aim of the study was to compare, over a duration o...
