Secondary prevention of fragility fractures: where do we stand during the COVID-19 pandemic?
Published in Journal of endocrinological investigation
Use of thyroid hormones in hypothyroid and euthyroid patients: A 2020 THESIS questionnaire survey of members of the Dani...
Published in Journal of endocrinological investigation
The standard treatment of hypothyroidism is levothyroxine (LT4), which is available as tablets or soft-gel capsules in Denmark. This study aimed to investigate Danish endocrinologists' use of thyroid hormones in hypothyroid and euthyroid patients. An e-mail with an invitation to participate in an online survey investigating practices about substitu...
Obesity in Prader-Willi syndrome: physiopathological mechanisms, nutritional and pharmacological approaches.
...Published in Journal of endocrinological investigation
Prader-Willi syndrome (PWS) is a genetic disorder caused by the lack of expression of genes on the paternally inherited chromosome 15q11.2-q13 region. The three main genetic subtypes are represented by paternal 15q11-q13 deletion, maternal uniparental disomy 15, and imprinting defect. Clinical picture of PWS changes across life stages. The main cli...
Interleukin-6 producing pheochromocytoma/paraganglioma: case series from a tertiary referral centre for pheochromocytoma...
Published in Journal of endocrinological investigation
In addition to catecholamines, pheochromocytomas and paragangliomas (PPGL) may secrete interleukin-6 (IL-6). IL-6 contributes to the development of unusual symptoms, which may hinder the diagnosis. We report the clinical course and subsequent treatment of IL-6 producing PPGL in three patients from a single tertiary referral centre for PPGL patients...
Vitamin D deficiency, secondary hyperparathyroidism and respiratory insufficiency in hospitalized patients with COVID-19...
...Published in Journal of endocrinological investigation
Hypovitaminosis D has emerged as potential risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the general population with variable effects on the outcome of the coronavirus disease-19 (COVID-19). The aim of this retrospective single-center study was to investigate the impact of hypovitaminosis D and secondary ...
PDE11A gene polymorphism in testicular cancer: sperm parameters and hormonal profile.
...Published in Journal of endocrinological investigation
Testicular germ cell tumours (TGCTs) is the most common malignancy among young adult males. The etiology is multifactorial and both environmental and genetic factors play an important role in the origin and development of TGCT. Genetic susceptibility may result from the interaction of multiple common and low-penetrance genetic variants and one of t...
The genetic background and vitamin D supplementation can affect irisin levels in Prader-Willi syndrome.
Published in Journal of endocrinological investigation
Prader-Willi syndrome (PWS) is associated to distinctive clinical symptoms, including obesity, cognitive and behavioral disorders, and bone impairment. Irisin is a myokine that acts on several target organs including brain adipose tissue and bone. The present study was finalized to explore circulating levels of irisin in children and adult PWS pati...
Vitamin D and Vitamin D binding protein: the inseparable duo in COVID-19.
Published in Journal of endocrinological investigation
POR polymorphisms are associated with 21 hydroxylase deficiency.
Published in Journal of endocrinological investigation
Genotype-phenotype correlation in congenital 21 hydroxylase deficiency is strong but by no means absolute. Indeed, clinical and hormonal features may vary among patients carrying similar CYP21A2 mutations, suggesting that modifier genes may contribute to the phenotype. Aim of the present study was to evaluate whether polymorphisms in the p450 oxido...
Effects of competitive physical activity on serum irisin levels and bone turnover markers.
Published in Journal of endocrinological investigation
Irisin, a myokine, is a polypeptide derived from the cleavage of the extracellular domain of fibronectin domain-containing protein 5, a receptor that is present on different tissues (skeletal muscle, pericardium, myocardium, and brain), whose functions are not yet fully defined. The main aim of our study was to evaluate the effect of competitive ph...
