van den Berg, Emma Nilsson, Johanna Kersten, Iris Brinkmalm, Gunnar de Kort, Anna M Klijn, Catharina J M Schreuder, Floris H B M Jäkel, Lieke Gobom, Johan Portelius, Erik
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Published in
Journal of Alzheimer's disease : JAD
Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) share pathogenic pathways related to amyloid-β deposition. Whereas AD is known to affect synaptic function, such an association for CAA remains yet unknown. We therefore aimed to investigate synaptic dysfunction in CAA. Multiple reaction monitoring mass spectrometry was used to quantify...
Ono, Rei Sakurai, Takashi Sugimoto, Taiki Uchida, Kazuaki Nakagawa, Takeshi Noguchi, Taiji Komatsu, Ayane Arai, Hidenori Saito, Tami
Published in
Journal of Alzheimer's disease : JAD
Prognosis-related information regarding dementia needs to be updated, as changes in medical and long-term care environments for patients with dementia in recent decades may be improving the prognosis of the disease. We aimed to investigate the mortality, cause of death, and prognostic factors by types of dementia in a Japanese clinic-based cohort. ...
Gyllenhammar, Måns Rennie, Anna Padilla, Daniel Ferreira Wallert, John Rydström, Anders Wahlund, Lars-Olof Eriksdotter, Maria Westman, Eric Ekman, Urban
Published in
Journal of Alzheimer's disease : JAD
Cognitive reserve (CR) is hypothesized to partially explain the discrepancy between Alzheimer's disease related brain pathology and cognitive performance. Educational attainment is often used as a proxy for CR. To examine the association of years of education and the relationship between atrophy in the medial temporal lobe and episodic memory, in a...
Andersson, John Sundström, Anna Nordin, Maria Segersson, David Forsberg, Bertil Adolfsson, Rolf Oudin, Anna
Published in
Journal of Alzheimer's disease : JAD
Growing evidence show that long term exposure to air pollution increases the risk of dementia. The aim of this study was to investigate associations between PM2.5 exposure and dementia in a low exposure area, and to investigate the role of olfaction and the APOE ɛ4 allele in these associations. Data were drawn from the Betula project, a longitudina...
Chatterjee, Pratishtha Doré, Vincent Pedrini, Steve Krishnadas, Natasha Thota, Rohith Bourgeat, Pierrick Ikonomovic, Milos D Rainey-Smith, Stephanie R Burnham, Samantha C Fowler, Christopher
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Published in
Journal of Alzheimer's disease : JAD
Astrocyte reactivity is an early event along the Alzheimer's disease (AD) continuum. Plasma glial fibrillary acidic protein (GFAP), posited to reflect astrocyte reactivity, is elevated across the AD continuum from preclinical to dementia stages. Monoamine oxidase-B (MAO-B) is also elevated in reactive astrocytes observed using 18F-SMBT-1 PET in AD....
Lilek, Jaclyn Ajroud, Kaouther Feldman, Alexander Z Krishnamachari, Sesha Ghourchian, Shadi Gefen, Tamar Spencer, Callen L Kawles, Allegra Mao, Qinwen Tranovich, Jessica F
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Published in
Journal of Alzheimer's disease : JAD
Phosphorylated cytoplasmic tau inclusions correlate with and precede cognitive deficits in Alzheimer's disease (AD). However, pathological tau accumulation and relationships to synaptic changes remain unclear. To address this, we examined postmortem brain from 50 individuals with the full spectrum of AD (clinically and neuropathologically). Total t...
Grasset, Leslie Power, Melinda C Crivello, Fabrice Tzourio, Christophe Chêne, Geneviève Dufouil, Carole
Published in
Journal of Alzheimer's disease : JAD
The long-term effects of traumatic brain injury (TBI) with loss of consciousness (LOC) on magnetic resonance imaging (MRI) markers of brain health and on dementia risk are still debated. To investigate the associations of history of TBI with LOC with incident dementia and neuroimaging markers of brain structure and small vessel disease lesions. The...
Voss, Tiffini Kost, James Mercer, Swati Pal Furtek, Christine Randolph, Christopher Lines, Christopher Egan, Michael F Cummings, Jeffrey L
Published in
Journal of Alzheimer's disease : JAD
Delay of progression from prodromal Alzheimer's disease (AD) to dementia is an important outcome in AD trials. Centralized adjudication is intended to improve the consistency of dementia diagnosis but has not been scrutinized. To evaluate centralized adjudication for determining progression to dementia compared with Site Investigator opinion or cha...
Newton, Princess Tchounguen, Jonathan Pettigrew, Corinne Lim, Chantelle Lin, Zixuan Lu, Hanzhang Moghekar, Abhay Albert, Marilyn Soldan, Anja
Published in
Journal of Alzheimer's disease : JAD
Alzheimer's disease (AD) frequently co-occurs with other brain pathologies. Recent studies suggest there may be a mechanistic link between AD and small vessel cerebrovascular disease (CVD), as opposed to simply the overlap of two disorders. We investigated the cross-sectional relationship between white matter hyperintensity (WMH) volumes (markers o...
Moebius, Hans J Church, Kevin J
Published in
Journal of Alzheimer's disease : JAD
An estimated 6.5 million Americans aged 65 years or older have Alzheimer's disease (AD), which will grow to 13.8 million Americans by 2060. Despite the growing burden of dementia, no fundamental change in drug development for AD has been seen in > 20 years. Currently approved drugs for AD produce only modest symptomatic improvements in cognition wi...
