Hanson, James V M Single, Sara Eberle, Rahel B Kana, Veronika Ineichen, Benjamin V Gerth-Kahlert, Christina
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Investigative ophthalmology & visual science
People with multiple sclerosis (pwMS) experience autoimmunity-mediated inflammation and neurodegeneration throughout the central nervous system. There remains a need for clinically accessible, reliable functional markers of neurodegeneration in MS. Previous research has described changes to electroretinography (ERG)-derived measures of retinal bipo...
Bansal, Manik Wang, Bingrui Waxman, Susannah Zhong, Fuqiang Hua, Yi Lu, Yuankai Reynaud, Juan Fortune, Brad Sigal, Ian A
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Investigative ophthalmology & visual science
IOP-induced mechanical insult on retinal ganglion cell axons within the optic nerve head (ONH) is believed to be a key factor in axonal damage and glaucoma. However, most studies focus on tissue-level mechanical deformations, overlooking that axons are long and thin, and that their susceptibility to damage likely depends on the insult's type (e.g. ...
Olufsen, Madeline E Hannibal, Jens Sørensen, Nina B Christiansen, Anders T Christensen, Ulrik C Pertile, Grazia Steel, David H Heegaard, Steffen Kiilgaard, Jens F
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Investigative ophthalmology & visual science
To investigate the histopathological changes following subretinal amniotic membrane transplantation in an in vivo porcine model of retinal holes. Left eyes of 12 Danish Landrace pigs were vitrectomized under full anesthesia. A subretinal bleb was created before excising a retinal hole (1154-2934 µm) using a 23-gauge vitrector. The pigs underwent tr...
Lin, Xueqi Zheng, Changyue Cong, Jing Feng, Qianhong Yuan, Jiayue Liu, Shichu Li, Hao Feng, Chenli Dai, Jinhui
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Investigative ophthalmology & visual science
Myopia development is closely associated with scleral tissue loss in both human and animal models. This research aimed to investigate the metabolic changes in the sclera of lens-induced myopic guinea pigs and explore the underlying mechanisms. Myopia was induced in 2-week-old pigmented guinea pigs by having them wear -20-diopter lenses for 10 days,...
Jaskoll, Shlomit Kramer, Adi Elbaz-Hayoun, Sarah Rinsky, Batya Eandi, Chiara M Grunin, Michelle Shwartz, Yahel Tiosano, Liran Heid, Iris M Winkler, Thomas
...
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Investigative ophthalmology & visual science
Adult-onset foveomacular vitelliform dystrophy (AFVD) shares phenotypic similarities with age-related macular degeneration (AMD). The genetic factors associated with AFVD are unknown in >80% of cases. This study evaluated the association of known AMD genetic risk variants with AFVD and compared systemic complement activation in these conditions. Cl...
Chuangsuwanich, Thanadet Tun, Tin A Braeu, Fabian A Chong, Rachel S Wang, Xiaofei Ho, Ching-Lin Aung, Tin Girard, Michaël J A Hoang, Quan V
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Investigative ophthalmology & visual science
To compare changes in macular curvature following acute IOP elevation across a range of myopic conditions. We studied 328 eyes from 184 subjects, comprising 32 emmetropic controls (between +2.75 and -2.75 diopters), 50 eyes with high myopia (
Ma, Sen Huis In't Veld, Ruben V de Los Pinos, Elisabet Ossendorp, Ferry A Jager, Martine J
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Investigative ophthalmology & visual science
Conjunctival melanoma (CJM) is a rare malignant ocular surface tumor, which often leads to local recurrences and metastases. In murine models of subcutaneous tumors, treatment with a novel virus-like drug conjugate (VDC; Bel-sar) showed a dual mechanism of action with direct tumor cell killing as well as stimulation of an antitumoral immune respons...
Zhang, Juan Ruan, Lu Jiang, Chen Yang, Qian Chang, Qing Huang, Xin
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Investigative ophthalmology & visual science
To investigate microvascular growth defects in the temporal midperipheral retina and their correlations with vitreoretinal microstructural abnormalities (VRMAs) in early-stage familial exudative vitreoretinopathy (FEVR). We enrolled 127 patients (127 eyes) with early-stage FEVR and 31 healthy subjects (31 eyes). Widefield optical coherence tomograp...
Kim, Yong Woo Sharpe, Glen P Siber, Julia Keßler, Ralf Fischer, Jörg Otto, Tilman Chauhan, Balwantray C
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Investigative ophthalmology & visual science
To assess the impact of working distance (WD) on optical distortion in optical coherence tomography (OCT) imaging and to evaluate the effectiveness of optical distortion correction in achieving consistent retinal Bruch's membrane (BM) layer curvature, regardless of variations in WD. Ten subjects underwent OCT imaging with four serial macular volume...
Yaman, Ebru Heyer, Nicole de Paiva, Cintia S Stepp, Mary Ann Pflugfelder, Stephen C Alam, Jehan
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Investigative ophthalmology & visual science
This study aimed to define the heterogeneity, spatial localization, and functional roles of immune cells in the mouse cornea using single-cell RNA sequencing (scRNA-seq) and immunofluorescent staining. Enriched mouse corneal immune cells (C57BL/6 strain, age 16-20 weeks) underwent single-cell RNA sequencing library preparation, sequencing, and anal...
