Bastia, Elena Toris, Carol B Brambilla, Stefania Galli, Corinna Almirante, Nicoletta Bergamini, Michael V W Masini, Emanuela Sgambellone, Silvia Unser, Andrea M Ahmed, Feryan
...
Published in
Investigative ophthalmology & visual science
NCX 667, a novel nitric oxide (NO) donor with an isomannide core, was characterized for its IOP-lowering ability in animal models of ocular hypertension and glaucoma. Bioengineered human trabecular meshwork/Schlemm's canal (HTM/HSC) constructs were used to explore the mode of action. Ocular normotensive New Zealand white (NZW) rabbits (ONT-rabbits)...
Borah, Naheed Arfin Sradhanjali, Swatishree Barik, Manas Ranjan Jha, Atimukta Tripathy, Devjyoti Kaliki, Swathi Rath, Suryasnata Raghav, Sunil K Patnaik, Srinivas Mittal, Ruchi
...
Published in
Investigative ophthalmology & visual science
Aurora kinase B (AURKB) plays a pivotal role in the regulation of mitosis and is gaining prominence as a therapeutic target in cancers; however, the role of AURKB in retinoblastoma (RB) has not been studied. The purpose of this study was to determine if AURKB plays a role in RB, how its expression is regulated, and whether it could be specifically ...
Snider, Eric J Hardie, Becky A Li, Yinglin Gao, Kristin Splaine, Fiona Kim, R Kijoon Vannatta, R Taylor Read, A Thomas Ethier, C Ross
Published in
Investigative ophthalmology & visual science
Re-cellularization of the trabecular meshwork (TM) using stem cells is a potential novel treatment for ocular hypertension associated with glaucoma. To assess the therapeutic efficacy of this approach, improved in vivo and ex vivo models of TM pathophysiology are needed. Here, we investigate whether oxidative stress, induced by hydrogen peroxide (H...
Kim, Yong-Kyu Yu, Hanyi Summers, Vivian R Donaldson, Kevin J Ferdous, Salma Shelton, Debresha Zhang, Nan Chrenek, Micah A Jiang, Yi Grossniklaus, Hans E
...
Published in
Investigative ophthalmology & visual science
To quantitatively evaluate the changes in orientation and morphometric features of mouse retinal pigment epithelial (RPE) cells in different regions of the eye during aging. We segmented individual RPE cells from whole RPE flatmount images of C57BL/6J mice (postnatal days 30 to 720) using a machine-learning method and evaluated changes in morphomet...
Qu, Jing-Yu Xiao, Yu-Ting Zhang, Ying-Ying Xie, Hua-Tao Zhang, Ming-Chang
Published in
Investigative ophthalmology & visual science
Meibomian glands play a vital role in maintaining ocular surface stability. This study aimed to investigate whether Hedgehog signaling is involved in the regulation of meibomian gland epithelial cells. Rat meibomian glands epithelial cells (RMGECs) were isolated from ducts and ductules, and then were cultivated to passage two on Matrigel coated wel...
Huang, Olivia S Seet, Li-Fong Ho, Henrietta W Chu, Stephanie W Narayanaswamy, Arun Perera, Shamira A Husain, Rahat Aung, Tin Wong, Tina T
Published in
Investigative ophthalmology & visual science
Aquaporins (AQPs) facilitate transmembrane osmotic water transport and may play a role in iris fluid conductivity, which is implicated in the pathophysiology of glaucoma. In this study, we compared the iris expression of AQPs and aqueous osmolality between primary angle closure glaucoma (PACG), primary open-angle glaucoma (POAG), and nonglaucoma ey...
Harrison, Krystal R Chervenak, Andrew P Resnick, Sarah M Reifler, Aaron N Wong, Kwoon Y
Published in
Investigative ophthalmology & visual science
Intrinsically photosensitive retinal ganglion cells (ipRGCs) signal not only centrally to non-image-forming visual centers of the brain but also intraretinally to amacrine interneurons through gap junction electrical coupling, potentially modulating image-forming retinal processing. We aimed to determine (1) which ipRGC types couple with amacrine c...
Schnabolk, Gloriane Obert, Elisabeth Banda, Nirmal K Rohrer, Bärbel
Published in
Investigative ophthalmology & visual science
Age-related macular degeneration (AMD) shares similar risk factors and inflammatory responses with rheumatoid arthritis (RA). Previously, we identified increased risk for dry AMD among patients with RA compared to control subjects, using retrospective data analysis. In this current study, we investigate the role of systemic inflammation triggered i...
Szarka, Dóra Elekes, Gréta Berczeli, Orsolya Vizvári, Eszter Szalay, László Ding, Chuanqing Tálosi, László Tóth-Molnár, Edit
Published in
Investigative ophthalmology & visual science
The role of adrenergic innervation in the regulation of lacrimal gland (LG) ductal fluid secretion is unknown. The Aim of the present study was to investigate the effect of adrenergic stimulation on fluid secretion in isolated LG duct segments and to study the underlying intracellular mechanisms. Fluid secretion of isolated mouse LG ducts was measu...
Walckling, Marcus Waterstradt, Rica Baltrusch, Simone
Published in
Investigative ophthalmology & visual science
To elucidate the collagen structure in the Descemet membrane (DM) of the human cornea and to characterize its rearrangement in patients with endothelial corneal dystrophies. Corneas from nine human donors and dystrophic DMs removed from 16 affected eyes of 13 patients by endothelial keratoplasty (DMEK) were investigated using a correlative RT-qPCR ...
