Zhao, Lu Jiang, Chenyang Tao, Yongli Gao, Yuan Xu, Yafang Zhang, Rui Liu, Kai Gu, Hongqiu Wang, Yilong Xu, Yuming
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Published in
International journal of stroke : official journal of the International Stroke Society
Minor ischemic stroke attack has taken a significant part of cerebrovascular disease burden. Benefits of thrombolysis in minor stroke is under debates and the use of urokinase in developing countries needs to be further explored. TRUST (ThRombolysis of Urokinase for minor STroke) trial was designed to evaluate the efficacy and safety of intravenous...
Sakakibara, Brodie M Lear, Scott A Barr, Susan I Goldsmith, Charlie H Schneeberg, Amy Silverberg, Noah D Yao, Jennifer Eng, Janice J
Published in
International journal of stroke : official journal of the International Stroke Society
Stroke Coach is a lifestyle coaching telehealth program to improve self-management of stroke risk factors. To examine the efficacy of Stroke Coach on lifestyle behavior and risk factor control among community-living stroke survivors within one-year post stroke. Participants were randomized to Stroke Coach or an attention control Memory Training gro...
Albers, Gregory W Campbell, Bruce Cv Lansberg, Maarten G Broderick, Joseph Butcher, Ken Froehler, Michael T Schwamm, Lee H Nouh, Amre M Liebeskind, David S Toy, Florence
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Published in
International journal of stroke : official journal of the International Stroke Society
While thrombolysis is standard of care for patients with acute ischemic stroke (AIS) within 4.5 h of symptom onset, the benefit of tenecteplase beyond this time window is less certain. The TIMELESS trial (NCT03785678) aims to determine if treatment with tenecteplase increases the proportion of good clinical outcomes among patients with stroke due t...
Nannoni, Stefania Ohlmeier, Laura Brown, Robin B Morris, Robin G MacKinnon, Andrew D Markus, Hugh S
Published in
International journal of stroke : official journal of the International Stroke Society
Whether cerebral microbleeds cause cognitive impairment remains uncertain. We analyzed whether cerebral microbleeds are associated with cognitive dysfunction in patients with symptomatic cerebral small vessel disease, and whether this association is independent of other neuroimaging markers of cerebral small vessel disease. We analyzed consecutive ...
Johnstone, Ainslie Brander, Fran Kelly, Kate Bestmann, Sven Ward, Nick
Published in
International journal of stroke : official journal of the International Stroke Society
Background: Difficulty using the upper-limb is a major barrier to independence for many patients post-stroke or brain injury. High dose rehabilitation can result in clinically significant improvements in function even years after the incident; however, there is still high variability in patient responsiveness to such interventions that cannot be ex...
Nogueira, Raul G Jovin, Tudor G Haussen, Diogo C Gupta, Rishi Jadhav, Ashutov Budzik, Ronald F Baxter, Blaise Krajina, Antonin Bonafe, Alain Malek, Ali
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Published in
International journal of stroke : official journal of the International Stroke Society
The effect of time from stroke onset to thrombectomy in the extended time window remains poorly characterized. We aimed to analyze the relationship between time to treatment and clinical outcomes in the early versus extended time windows. Proximal anterior circulation occlusion patients from a multicentric prospective registry were categorized into...
Janssen, Heidi Ada, Louise Middleton, Sandy Pollack, Michael Nilsson, Michael Churilov, Leonid Blennerhassett, Jannette Faux, Steven New, Peter McCluskey, Annie
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Published in
International journal of stroke : official journal of the International Stroke Society
Environmental enrichment involves organization of the environment and provision of equipment to facilitate engagement in physical, cognitive, and social activities. In animals with stroke, it promotes brain plasticity and recovery. To assess the feasibility and safety of a patient-driven model of environmental enrichment incorporating access to com...
Lindgren, Arne G Braun, Robynne G Juhl Majersik, Jennifer Clatworthy, Philip Mainali, Shraddha Derdeyn, Colin P Maguire, Jane Jern, Christina Rosand, Jonathan Cole, John W
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Published in
International journal of stroke : official journal of the International Stroke Society
Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variat...
Bhattarai, Nawaraj Price, Christopher I McMeekin, Peter Javanbakht, Mehdi Vale, Luke Ford, Gary A Shaw, Lisa
Published in
International journal of stroke : official journal of the International Stroke Society
The Paramedic Acute Stroke Treatment Assessment (PASTA) trial evaluated an enhanced emergency care pathway which aimed to facilitate thrombolysis in hospital. A pre-planned health economic evaluation was included. The main results showed no statistical evidence of a difference in either thrombolysis volume (primary outcome) or 90-day dependency. Ho...
Ewbank, Frederick Birks, Jacqueline Bulters, Diederik
Published in
International journal of stroke : official journal of the International Stroke Society
Some studies have shown a protective association between aspirin use and subarachnoid hemorrhage. Other studies have found no relationship or the reverse. These studies differ in their study populations and definitions of subarachnoid hemorrhage. Our aim was to establish (1) if there is an association between aspirin and subarachnoid hemorrhage, (2...
