Yin, Caiyun Hu, Peiyun Qin, Lijing Wang, Zhicheng Zhao, Hongguang
Published in
International journal of nanomedicine
Molecular imaging is an advanced technology that utilizes specific probes or markers in conjunction with cutting-edge imaging techniques to observe and analyze the localization, distribution, activity, and interactions of biomolecules within living organisms. Tumor molecular imaging, by enabling the visualization and quantification of molecular cha...
Cao, Jiamin Zhang, Feng Chen, Haiyan Wu, Bingxuan Yin, Jiayang Chenzhao, Changci Xiong, Wei
Published in
International journal of nanomedicine
Manifestations of thyroid-associated ophthalmopathy (TAO) vary greatly. Few tools and indicators are available to assess TAO, restricting personalized diagnosis and treatment. To identify an aptamer targeting thyroid-stimulating hormone receptor (TSHR) and utilize this aptamer to evaluate clinical activity in patients with TAO. An aptamer targeting...
Ngo, Hai V Bak, Hye-Eun Nguyen, Hy D Lee, Kye Wan Park, Chulhun Lee, Beom-Jin
Published in
International journal of nanomedicine
Leuprolide (LEU), a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH), could exert a direct inhibitory activity on the proliferation of prostate cancer cells. However, the short half-life in blood and the biopharmaceutical problem of LEU limit this anticancer activity. To improve its druggability for improvin...
Guerrero-Arguero, Israel Khan, Siddiqur Rahman Henry, Brandon M Garcia-Vilanova, Andreu Chiem, Kevin Ye, Chengjin Shrestha, Sweta Knight, Deborah Cristner, Mark Hill, Shauna
...
Published in
International journal of nanomedicine
The coronavirus disease 2019 (COVID-19) pandemic has demonstrated the need for novel, affordable, and efficient reagents to help reduce viral transmission, especially in high-risk environments including medical treatment facilities, close quarters, and austere settings. We examined transition-metal nanozeolite suspensions and quaternary ammonium co...
Aldawsari, Mohammed F Alhowail, Ahmad H Anwer, Md Khalid Ahmed, Mohammed Muqtader
Published in
International journal of nanomedicine
The aim of the present investigation is to prepare baricitinib (BAR)-loaded diphenyl carbonate (DPC) β-cyclodextrin (βCD) based nanosponges (NSs) to improve the oral bioavailability. BAR-loaded DPC-crosslinked βCD NSs (B-DCNs) were prepared prepared by varying the molar ratio of βCD: DPC (1:1.5 to 1:6). The developed B-DCNs loaded with BAR were cha...
Deng, Hao Wang, Yumei Zhou, Yue Zhai, Dongliang Chen, Jie Hao, Shilei Chen, Xiaoliang
Published in
International journal of nanomedicine
Prostate cancer (PCa) ranks second in the incidence of all malignancies in male worldwide. The presence of multi-organ metastases and tumor heterogeneity often leads to unsatisfactory outcomes of conventional radiotherapy treatments. This study aimed to develop a novel folate-targeted nanohydroxyapatite (nHA) coupling to deliver adriamycin (Doxorub...
Rui, Tao Wang, Kai Xiang, Aizhai Guo, Jufeng Tang, Ning Jin, Xin Lin, Yimou Liu, Jian Zhang, Xiaobing
Published in
International journal of nanomedicine
Serum exosome-based liquid biopsy has significant advantages for screening and diagnosing hepatocellular carcinoma (HCC). P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are novel small silencing RNAs that have been identified to function in cancer-related signalling pathways. However, studies on the presence of piRNAs in serum exos...
Wu, Yingli Yang, Yu Lv, Xiaolin Gao, Menghan Gong, Xujin Yao, Qingqiang Liu, Yanna
Published in
International journal of nanomedicine
Ovarian cancer is one of the most common malignant tumors in gynecology with a high incidence. Combination therapy, eg, administration of paclitaxel followed by a platinum anticancer drug is recommended to treat ovarian cancer due to its advantages in, eg, reducing side effects and reversing (multi)drug-resistance compared to single treatment. Howe...
Shehata, Mustafa K Ismail, Assem A Kamel, Maher A
Published in
International journal of nanomedicine
Astaxanthin (AST) is a second-generation antioxidant with anti-inflammatory and neuroprotective properties and could be a promising candidate for Alzheimer's disease (AD) therapy, but is shows poor oral bioavailability due to its high lipophilicity. This study aimed to prepare and evaluate AST-loaded nanostructured lipid carriers (NLCs), for enhanc...
Lim, Chaemin Shin, Yuseon Kang, Kioh Husni, Patihul Lee, Dayoon Lee, Sehwa Choi, Han-Gon Lee, Eun Seong Youn, Yu Seok Oh, Kyung Taek
...
Published in
International journal of nanomedicine
Ligand-conjugated liposomes are promising for the treatment of specific receptor-overexpressing cancers. However, previous studies have shown inconsistent results because of the varying properties of the ligand, presence of a polyethylene glycol (PEG) coating on the liposome, length of the linker, and density of the ligand. Here, we prepared PEGyla...
