Ahmed, Asma Kramer, Michael S Bernard, Jonathan Y Perez Trejo, Maria Esther Martin, Richard M Oken, Emily Yang, Seungmi
Published in
International journal of epidemiology
Most studies of associations between child growth and cognitive ability were based on size at one or two ages and a single measure of cognition. We aimed to characterize different aspects of early growth and their associations with cognitive outcomes in childhood through adolescence. In a sample of 12 368 Belarusian children born at term, we examin...
VanderWeele, Tyler J Mathur, Maya B
Published in
International journal of epidemiology
Gill, Dipender Walker, Venexia M Martin, Richard M Davies, Neil M Tzoulaki, Ioanna
Published in
International journal of epidemiology
Verkouter, Inge de Mutsert, Renée Smit, Roelof A J Trompet, Stella Rosendaal, Frits R van Heemst, Diana Willems van Dijk, Ko Noordam, Raymond
Published in
International journal of epidemiology
Body mass index (BMI)-associated loci are used to explore the effects of obesity using Mendelian randomization (MR), but the contribution of individual tissues to risks remains unknown. We aimed to identify tissue-grouped pathways of BMI-associated loci and relate these to cardiometabolic disease using MR analyses. Using Genotype-Tissue Expression ...
Breskin, Alexander Murray, Eleanor J
Published in
International journal of epidemiology
Ma, Yixuan Ajnakina, Olesya Steptoe, Andrew Cadar, Dorina
Published in
International journal of epidemiology
Several risk factors contribute to dementia, but the role of obesity remains unclear. This study investigated whether increased body weight or central obesity were associated with a higher risk of developing dementia in a representative sample of older English adults. We studied 6582 participants from the English Longitudinal Study of Ageing (ELSA)...
Walker, Venexia M Kehoe, Patrick G Martin, Richard M Davies, Neil M
Published in
International journal of epidemiology
Evidence concerning the potential repurposing of antihypertensives for Alzheimer's disease prevention is inconclusive. We used Mendelian randomization, which can be more robust to confounding by indication and patient characteristics, to investigate the effects of lowering systolic blood pressure, via the protein targets of different antihypertensi...
Zhou, Huaqiang Shen, Jiayi Fang, Wenfeng Liu, Jiaqing Zhang, Yaxiong Huang, Yan Zhang, Li
Published in
International journal of epidemiology
Howe, Laura D Kanayalal, Roshni Harrison, Sean Beaumont, Robin N Davies, Alisha R Frayling, Timothy M Davies, Neil M Hughes, Amanda Jones, Samuel E Sassi, Franco
...
Published in
International journal of epidemiology
We assessed whether body mass index (BMI) affects social and socio-economic outcomes. We used Mendelian randomization (MR), non-linear MR and non-genetic and MR within-sibling analyses, to estimate relationships of BMI with six socio-economic and four social outcomes in 378 244 people of European ancestry in UK Biobank. In MR of minimally related i...
Li, Shuai Bui, Minh Hopper, John L
Published in
International journal of epidemiology
We developed a method to make Inference about Causation from Examination of FAmiliaL CONfounding (ICE FALCON) using observational data for related individuals and considering changes in a pair of regression coefficients. ICE FALCON has some similarities to Mendelian randomization (MR) but uses in effect all the familial determinants of the exposure...
