Monitoring the Response of Hyperbilirubinemia in the Mouse Brain by In Vivo Bioluminescence Imaging
Published in International Journal of Molecular Sciences in Dec 28, 2016
Monitoring the Response of Hyperbilirubinemia in the Mouse Brain by In Vivo Bioluminescence Imaging
Published in International Journal of Molecular Sciences in Dec 28, 2016
Monitoring the response of hyperbilirubinemia in the mouse brain by in vivo bioluminescence imaging
Published in International Journal of Molecular Sciences in Dec 28, 2016
Increased levels of unconjugated bilirubin are neurotoxic, but the mechanism leading to neurological damage has not been completely elucidated. Innovative strategies of investigation are needed to more precisely define this pathological process. By longitudinal in vivo bioluminescence imaging, we noninvasively visualized the brain response to hyper...
Promotion of Survival and Engraftment of Transplanted Adipose Tissue-Derived Stromal and Vascular Cells by Overexpressio...
Published in International Journal of Molecular Sciences in July 2016
Short-term persistence of transplanted cells during early post-implant period limits clinical efficacy of cell therapy. Poor cell survival is mainly due to the harsh hypoxic microenvironment transplanted cells face at the site of implantation and to anoikis, driven by cell adhesion loss. We evaluated the hypothesis that viral-mediated expression of...
Effects of the Olive-Derived Polyphenol Oleuropein on Human Health
Published in International Journal of Molecular Sciences in Oct 05, 2014
The use of the products derived from the olive tree on human health dates back centuries. In several civilizations, the olive tree had and still has a very strong cultural and religious symbolism. Notably, the official seal and emblem of the World Health Organization features the rod of Asclepius over a world map surrounded by olive tree branches, ...
Detection of a specific biomarker for Epstein-Barr virus using a polymer-based genosensor.
Published in International Journal of Molecular Sciences in 2014
This paper describes methodology for direct and indirect detections of a specific oligonucleotide for Epstein-Barr virus (EBV) using electrochemical techniques. The sequence of oligonucleotide probe (EBV1) revealed a high sequence identity (100%) with the EBV genome. For the development of the genosensor, EBV1 was grafted to the platform sensitized...
Single nucleotide polymorphisms in growth hormone gene and their association with growth traits in Siniperca chuatsi (Ba...
Published in International Journal of Molecular Sciences in 2014
Growth hormone (GH) has been considered as a candidate gene for growth traits in fish. In this study, polymorphisms of the GH gene were evaluated for associations with growth traits in 282 Siniperca chuatsi individuals. Using directly sequencing, four single nucleotide polymorphisms (SNPs) were identified in GH gene, with two mutations in intron 4 ...
Electricity generation and wastewater treatment of oil refinery in microbial fuel cells using Pseudomonas putida.
Published in International Journal of Molecular Sciences in 2014
Microbial fuel cells (MFCs) represent a novel platform for treating wastewater and at the same time generating electricity. Using Pseudomonas putida (BCRC 1059), a wild-type bacterium, we demonstrated that the refinery wastewater could be treated and also generate electric current in an air-cathode chamber over four-batch cycles for 63 cumulative d...
The NO/ONOO-Cycle as the Central Cause of Heart Failure
Published in International Journal of Molecular Sciences in Nov 01, 2013
The NO/ONOO-cycle is a primarily local, biochemical vicious cycle mechanism, centered on elevated peroxynitrite and oxidative stress, but also involving 10 additional elements: NF-κB, inflammatory cytokines, iNOS, nitric oxide (NO), superoxide, mitochondrial dysfunction (lowered energy charge, ATP), NMDA activity, intracellular Ca2+, TRP receptors...
Arabidopsis Non-Coding RNA Regulation in Abiotic Stress Responses
Published in International Journal of Molecular Sciences in Nov 01, 2013
Plant growth and productivity are largely affected by environmental stresses. Therefore, plants have evolved unique adaptation mechanisms to abiotic stresses through fine-tuned adjustment of gene expression and metabolism. Recent advanced technologies, such as genome-wide transcriptome analysis, have revealed that a vast amount of non-coding RNAs (...