Higuchi, Shinya Wu, Rongqian Zhou, Mian Marini, Corrado P Ravikumar, Thanjavur S Wang, Ping
Published in
International journal of clinical and experimental pathology
Ischemia bowel remains a critical problem resulting in up to 80% mortality. The loss of gut barrier function plays an important role. Our previous studies have shown that administration of adrenomedullin (AM), a novel vasoactive peptide, and its binding protein (AMBP-1), reduces the systemic inflammatory response and organ injury after systemic isc...
Esnault, Stéphane Rosenthal, Louis A Wang, Deng-Shun Malter, James S
Published in
International journal of clinical and experimental pathology
The rising worldwide prevalence of asthma has intensified interest in the natural history of asthma. An improved understanding of the genetic, environmental, and developmental factors contributing to the inception and exacerbation of asthma will be crucial to efforts to devise effective preventive and therapeutic interventions. There is increasing ...
Carns, Bhavini Fadare, Oluwole
Published in
International journal of clinical and experimental pathology
Studies evaluating the routine Papanicolaou (Pap) test have traditionally used as the reference gold standard, the diagnoses on the follow-up histologic samples. Since the latter are typically obtained days to weeks after the Pap test, the accuracy of the resultant comparison may be affected by interim factors, such as regression of human papilloma...
Truong, Camtu D Li, Wei Feng, Wei Cagle, Philip Khoury, Thaer Alrawi, Sadir Xie, Keping Yao, James Tan, Dongfeng
Published in
International journal of clinical and experimental pathology
Alpha-methylacyl-CoA racemase (AMACR [P504S]) is a mitochondrial and peroxisomal enzyme involved in beta-oxidation of dietary branched-chain fatty acids and their derivatives. Recent studies showed that AMACR is expressed in several neoplasms, including prostate and colon cancer. However, AMACR expression in gastric neoplasms has yet to be thorough...
Hong, Seung-Mo Kim, Mi-Jung Jang, Kee-Taek Yoon, Ghil-Suk Cho, Hyungjun Frierson, Henry F Yu, Eunsil
Published in
International journal of clinical and experimental pathology
Adenosquamous carcinoma is a rare histologic subtype of extrahepatic bile duct (EBD) carcinoma and limited information is available on its clinicopathologic characteristics. Twelve cases of adenosquamous carcinoma were collected from 3 institutions and their clinicopathologic characteristics were examined and compared with those of 176 EBD adenocar...
Xie, Qingmei Chen, Lugen Fu, Kai Harter, Josephine Young, Ken H Sunkara, Jaya Novak, Deborah Villanueva-Siles, Esperanza Ratech, Howard
Published in
International journal of clinical and experimental pathology
The diagnosis of follicular dendritic cell (FDC) sarcoma can be challenging because of its morphologic overlaps with many other spindle cell neoplasms and, therefore, new phenotypic markers will be helpful in its differential diagnosis. Podoplanin is a mucin-type transmembrane glycoprotein that has recently been detected in reactive FDCs. In this s...
Roma, Andres A Goldblum, John R Fazio, Victor Yang, Bin
Published in
International journal of clinical and experimental pathology
14-3-3sigma is a p53-regulated G2/M inhibitor involved in numerous cellular signaling pathways related to cell cycle, DNA repair and apoptosis. Recent studies have showed that 14-3-3sigma was silenced transcriptionally through promoter hypermethylation mainly in HPV-negative vulvar squamous cell carcinoma (SCC). However, the expression of 14-3-3sig...
Izal, Iñigo Ripalda, Purificación Acosta, Carlos A Forriol, Francisco
Published in
International journal of clinical and experimental pathology
We studied the effect of freezing and inserting meniscal plugs in lesions generated in the avascular area of sheep menisci maintained in vitro, and whether the healing process can be improved by adding growth factors TGF-beta1 and IGF-1. Thirty six menisci obtained from healthy 3 months-old sheep were cultured in 6 well plates and holes were perfor...
Hudnall, S David Chen, Tiansheng Amr, Samir Young, Ken H Henry, Kristin
Published in
International journal of clinical and experimental pathology
Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a subacute inflammatory disorder most often seen in young women with clinicopathologic features suggestive of an infectious etiology. The most commonly suspected infectious agents in KFD are the human herpesviruses EBV, HHV6, HHV7 and HHV8. In order to identify herpesvirus...
Simon, Rochelle A di Sant'agnese, P Anthony Palapattu, Ganesh S Singer, Eric A Candelario, Grace D Huang, Jiaoti Yao, Jorge L
Published in
International journal of clinical and experimental pathology
We report a unique case of mucinous tubular and spindle cell carcinoma (MTSC) of the kidney with extensive sarcomatoid differentiation, multiple metastases, and a rapidly fatal clinical course. The patient presented with back pain and a pathologic L1 fracture. Diagnostic imaging revealed a large retroperitoneal mass arising from the left kidney and...
