Brown, Robert E Zotalis, George Zhang, Ping L Zhao, Bihong
Published in
International journal of clinical and experimental pathology
Preclinical studies have implicated the mammalian target of rapamycin (mTOR) pathway in the cell cycle progression and growth of prostate cancer cells. Downstream signaling from PI3'-K/Akt leads to phosphorylation (p) of mTOR at serine 2448 and to activation of its substrate, p70S6Kinase (p70S6K), phosphorylated on threonine 389. This promotes tran...
Liang, John J Alrawi, Sadir Fuller, Gregory N Tan, Dongfeng
Published in
International journal of clinical and experimental pathology
Tailgut cysts are uncommon developmental cysts that form in the presacral space. Complications of tailgut cysts include benign reactive lesions associated with infection and inflammation, and malignant transformation. Six cases of carcinoid tumor arising in tailgut cysts have been reported in the medical literature to date. Here we report another c...
Fujino, Yasuhiro Dickson, Dennis W
Published in
International journal of clinical and experimental pathology
Microvacuolation is relatively common in the limbic lobe in Lewy body disease (LBD). Similar pathology has also been reported in Alzheimer's disease (AD). Almost all of the studies of microvacuolation in AD, however, antedated the routine application of sensitive immunohistochemical methods to detect Lewy bodies. This raises the possibility that mi...
Li, Guangyu Duan, Tao Wu, Xiaoyan Tesh, Robert B Soong, Lynn Xiao, Shu-Yuan
Published in
International journal of clinical and experimental pathology
Infection of primates by yellow fever virus (YFV) often results in severe multi-organ failure with marked histologic abnormalities. However, the role of host's immune response, particularly innate immunity, in disease process is unclear. In this study, we used a well established hamster model of yellow fever to examine the dynamic changes of cytoki...
Xiao, Shu-Yuan Lu, Liang Wang, Hanlin L
Published in
International journal of clinical and experimental pathology
Fibrosing cholestatic hepatitis (FCH) is a rapidly progressive, sometimes fatal form of liver injury. Though originally reported in liver transplant recipients with recurrent hepatitis B, it has now been recognized frequently in chronic hepatitis B or C patients who are under immunosuppression. The histopathologic hallmarks in the liver include mar...
Cookson, Mark R Hardy, John Lewis, Patrick A
Published in
International journal of clinical and experimental pathology
Parkinson's disease (PD) has long been considered to be a sporadic entity, perhaps with an environmental etiology. However, recent genetic discoveries have challenged this view, as there are many families with diseases of Mendelian inheritance that clinically resemble PD. Here, we will review in detail the neuropathological data relating to familia...
Zhang, Lanjing Chen, Zheng Fukuma, Mariko Lee, Lisa Y Wu, Maoxin
Published in
International journal of clinical and experimental pathology
Carcinosarcoma of gallbladder, also named sarcomatoid carcinoma and spindle cell carcinoma, is a rare neoplasm. Its clinical features and prognostic determinants are still poorly understood due to its rarity. We identified 67 qualified cases in published literatures and 1 in our institution. 52 of them were females and 16 males (F:M=3.25:1). 27 wer...
Li, Shiyong Dickson, Dennis W Iacobuzio-Donahue, Christine A Wang, Dengshun
Published in
International Journal of Clinical and Experimental Pathology
Carl, Joseph W Bai, Xue-Feng
Published in
International journal of clinical and experimental pathology
IL27 is the newest member of the IL6/IL12 family. It consists of Epstein-Barr virus-induced gene 3 (EBI3) and p28 subunits and signals through the IL27 receptor complex formed by WSX-1 and gp130 subunits. IL27-IL27 receptor interaction was initially shown to induce an early signal for the induction of Th1 responses. Recently other studies indicate ...
Hall, Jordan M Saenger, Jeff S Fadare, Oluwole
Published in
International journal of clinical and experimental pathology
The pathologic distinction of atypical fibroxanthomas (AFXs) from cutaneous spindle cell/sarcomatoid squamous cell carcinomas (SCSCCs) may occasionally pose a significant diagnostic challenge, given the substantial clinicopathologic overlap between these lesions. Recent studies indicate that p63 and CD10 are expressed in significant proportions of ...
