Liang, Xiuqing Bai, Jian Chen, Baoguang
Published in
International Journal of Clinical and Experimental Pathology
Background: EPDR1 is widely expressed in cancer, especially colorectal cancer. However, the biologic function of EPDR1 in breast cancer is uncertain. Methods: The expression profile of EPDR1 was assessed by Gene Expression Profiling Interactive Analysis ( GEPIA ; gepia.cancer-pku.cn). We constructed EPDR1-overexpressing (EPDR1-Ov) plasmids that wer...
Yi, Shun Zhou, Wei
Published in
International Journal of Clinical and Experimental Pathology
Breast cancer (BC) in adolescents and young adults (AYAs) accounts for 5.6% of BC in all women. BC in this population is often characterized as aggressive. Two-thirds of BC in AYAs belong to the hormone-receptor positive (HR(+))/human epidermal growth factor receptor 2 negative (HER2(-)) subtype. However, the underlying pathogenesis of this subtype...
Chen, Yanxian Hu, Xiaofeng Yang, Shu
Published in
International Journal of Clinical and Experimental Pathology
Focal adhesion kinase is a non-receptor, tyrosine kinase of cells whose key functions are cell adhesion, migration, and invasion. Aberrant expression and regulation of FAK-mediated intracellular signaling pathways has been reported in several cancers and they are involved in cancer cell migration and apoptosis resistance. By RT-PCR, we found that c...
Duan, Shijun Shi, Jiayu Shi, Bing Jia, Zhonglin
Published in
International Journal of Clinical and Experimental Pathology
Cleft alveolar is often accompanied by non-syndromic cleft lip with/without palate (NSCL/P), which could seriously affect the growth and development of the maxilla. In this study, we assessed the associations between 47 susceptible SNPs from previous GWASs of NSCL/P and cleft alveolar in Western Han Chinese population. We recruited 228 trios of NSC...
Wang, Jing Pang, Yaqian Cao, Feng Zhu, Hao Zhang, Kai
Published in
International Journal of Clinical and Experimental Pathology
Neurofibromatosis is an autosomal dominant genetic disease that originates from neuroepithelial tissue and involves disorders of ectoderm and mesoderm. At present, there are relatively few reports of neurofibroma type I in children. Therefore, understanding the clinical manifestations, diagnosis, and treatment of neurofibromatosis is of great signi...
Xiong, Zhuyou Jiang, Banghong Li, Guangzao
Published in
International Journal of Clinical and Experimental Pathology
Background: Cutaneous squamous cell carcinoma (cSCC) is a malignancy of epidermal keratinocytes which accounts for approximately one-third of skin cancer-related death yearly. In this study, we aim to investigate the mechanism of miR-10a in regulating cellular function of cSCC cells and its possible role in prognosis of cSCC. Methods: The expressio...
Zhu, Xiuli Hu, Bo Hu, Ming Qian, Dongmeng Wang, Bin
Published in
International Journal of Clinical and Experimental Pathology
Objective: This study aims to investigate the effect of human cytomegalovirus (HCMV) infection on epithelial-to-mesenchymal transition (EMT) in glioblastoma cells and the possible underlying molecular mechanism. Methods: We established primary cell cultures and measured the expression of the HCMV immediate early protein (IE1) to determine HCMV infe...
Li, Qiu-Xia Li, Ning-Qin Liao, Jin-Yuan
Published in
International Journal of Clinical and Experimental Pathology
Previous studies found that Forkhead box D4 ( FOXD4 ) overexpressed in human colorectal cancer had the worst prognosis. However, the diagnostic value and further mechanism have not been fully researched. Statistical examinations for FOXD4 expression colon adenocarcinoma (COAD) patients were obtained from The Cancer Genome Atlas (TCGA). Survival ana...
Ding, Zhao-Ran Qiang, Hua-Long Cheng, Zhong-Qiang Zhan, Xiao-Dong
Published in
International Journal of Clinical and Experimental Pathology
Objective: To report an unusual case describing a plexiform Schwannoma in the ear cavity of a young child. Patient: A 3-year-old girl. Interventions: The tumor was entirely removed by surgery, the pathologic diagnosis of the isolated tissue was performed, and the surgical incision was routinely treated. Main outcome measure: Report the main clinica...
Wu, Jing Liu, Yaqiong Hu, Jun Xie, Jun Nie, Zuqiong Yin, Wanling
Published in
International Journal of Clinical and Experimental Pathology
Allergic asthma is a chronic lung disease characterized by wheezing, coughing, chest tightness and shortness of breath. Clinically, the treatments against asthma focus on controlling the symptoms rather than inhibiting recurrence radically. Additionally, local and systemic side effects caused by current treatments are worthy of attention. Therefore...
