Tamkin, Emily Lorenz, Brian P McCarty, Arianna Fulte, Sam Eisenmesser, Elan Horswill, Alexander R Clark, Sarah E
Published in
Infection and immunity
The composition of the respiratory tract microbiome is a notable predictor of infection-related morbidities and mortalities among both adults and children. Species of Corynebacterium, which are largely present as commensals in the upper airway and other body sites, are associated with lower colonization rates of opportunistic bacterial pathogens su...
Harris, Macallister C. Gary, Hadley E. Cooper, Sarah K. Ackart, David F. DiLisio, James E. Basaraba, Randall J. Cheng, Tan-Yun van Rhijn, Ildiko Branch Moody, D. Podell, Brendan K.
...
Published in
Infection and Immunity
CD1 is an antigen-presenting glycoprotein homologous to MHC I; however, CD1 proteins present lipid rather than peptide antigens. CD1 proteins are well established to present lipid antigens of Mycobacterium tuberculosis (Mtb) to T cells, but understanding the role of CD1-restricted immunity in vivo in response to Mtb infection has been limited by th...
Beenken, Karen E. Campbell, Mara J. Smeltzer, Mark S.
Published in
Infection and Immunity
The persistent emergence of antibiotic-resistant strains has rekindled interest in anti-virulence strategies to combat S. aureus infections. Numerous reports describe anti-virulence strategies focusing on key regulatory elements that globally influence virulence factor production, the two most commonly targeted being the accessory gene regulator (a...
FitzPatrick, Rachael D. Noone, Jonathan R. Cartwright, Richard A. Gatti, Dominique M. Brosschot, Tara P. Lane, Jenna M. Jensen, Erik L. Kroker Kimber, Isabella Reynolds, Lisa A.
Published in
Infection and Immunity
Eosinophils are a highly abundant cell type in the gastrointestinal tract during homeostatic conditions, where they have recently been reported to take on an activated phenotype following colonization by the bacterial microbiota. To date, there have been few studies investigating whether eosinophils respond to infection with enteric bacterial patho...
Anand, Apeksha Gautam, Gunjan Srivastava, Gaurava Yadav, Shailendra Ramalingam, Karthik Siddiqi, Mohammad Imran Goyal, Neena
Published in
Infection and Immunity
Chaperonins/Heat shock protein 60 are ubiquitous multimeric protein complexes that assist in the folding of partially and/or misfolded proteins using metabolic energy into their native stage. The eukaryotic group II chaperonin, also referred as T-complex protein-1 ring complex (TRiC)/T-complex protein-1 (TCP1)/chaperonin containing T-complex protei...
Lu, Yaqi Liu, Jing Tang, Wangxian Zhang, Heng
Published in
Infection and Immunity
To research the role of the NLRP3 inflammasome in Schistosoma japonicum-induced granuloma formation and liver fibrosis. In in vivo tests, BALB/c mice were used. shNLRP3 plasmid based on adeno-associated virus serotype 8 (AAV8-shNLRP3) was injected to block NLRP3 inflammasome via tail vein. Serum alanine aminotransferase (ALT) and aspartate aminotra...
Chorro, Laurent Ciolino, Tara Torres, Caresse Lynn Illenberger, Arthur Aglione, JohnPaul Corts, Paula Lypowy, Jacqueline Ponce, Christopher La Porte, Annalena Burt, Deborah
...
Published in
Infection and Immunity
The increase in urinary tract infections (UTI) caused by antibiotic-resistant Escherichia coli requires the development of new therapeutic agents and prophylactic vaccines. To evaluate the efficacy of new lead candidates, we implemented a cynomolgus macaque UTI challenge model that mimics human uncomplicated cystitis in response to transurethral ch...
Jensen, Owen Trujillo, Emma Hanson, Luke Ost, Kyla S.
Published in
Infection and Immunity
The intestinal microbiome harbors fungi that pose a significant risk to human health as opportunistic pathogens and drivers of inflammation. Inflammatory and autoimmune diseases are associated with dysbiotic fungal communities and the expansion of potentially pathogenic fungi. The gut is also the main reservoir for disseminated fungal infections. I...
Parrish, Katelyn M. Gestal, Monica C.
Published in
Infection and Immunity
Traditionally, eosinophils have been linked to parasitic infections and pathological disease states. However, emerging literature has unveiled a more nuanced and intricate role for these cells, demonstrating their key functions in maintaining mucosal homeostasis. Eosinophils exhibit diverse phenotypes and exert multifaceted effects during infection...
Westland, Mandy D. Schrimpe-Rutledge, Alexandra C. Codreanu, Simona G. Sherrod, Stacy D. McLean, John A. McClain, Mark S. Cover, Timothy L.
Published in
Infection and Immunity
Colonization of the human stomach with Helicobacter pylori strains producing active forms of the secreted toxin VacA is associated with an increased risk of peptic ulcer disease and gastric cancer, compared with colonization with strains producing hypoactive forms of VacA. Previous studies have shown that active s1m1 forms of VacA cause cell vacuol...