Published in Indian Journal of Pharmacology
Glaucoma is a slow progressive degeneration of the retinal ganglion cells (RGCs) and the optic nerve axons, leading to irreversible blindness if left undiagnosed and untreated. Although increased intraocular pressure is a major risk factor of glaucoma, other factors include increased glutamate levels, alterations in nitric oxide (NO) metabolism, va...
Published in Indian Journal of Pharmacology
Objective: To review the pharmacology, clinical efficacy and safety of partial agonists of α4β2 nicotinic acetylcholine receptor. Data Sources: Primary literature and review articles were obtained via a PUBMED search (1988-August 2006) using the key terms smoking cessation, partial agonist alpha4beta2 nicotinic acetylcholine receptor, varenicline, ...
Published in Indian Journal of Pharmacology
Objective: To study the hypolipidemic activity of fresh grass juice of Triticum aestivum in normal rats. Materials and Methods: Freshly prepared Triticum aestivum grass juice was administered to normal rats at the dose of 5 ml/kg and 10 ml/kg orally once daily for 21 days. Blood samples were collected after 24 hours of last administration and used ...
Published in Indian Journal of Pharmacology
Objective: To isolate the active fraction from crude extract of Gracilaria changii and to determine its in vitro antifungal activity. Materials and Methods: The active fraction was isolated from the crude extract of G. changii by various purification procedures such as column chromatography, thin layer chromatography, bioauthograph etc. The in vitr...
Published in Indian Journal of Pharmacology
Objective: To improve the detection limit of 3′-hydroxy-stanozolol by using the double extraction procedure, specific for basic drugs. Materials and Methods: The urine samples were spiked in four replicates with 3′-hydroxy-stanozolol at different concentrations of 1, 2, 5 and 10 ng/mL, processed by two different methods and injected into gas chroma...
Published in Indian Journal of Pharmacology
Objectives: To study the effects of Parthenium hysterophorus L. flower on serum glucose level in normal and alloxan induced diabetic rats. Materials and Methods: Albino rats were divided into six groups of six animals each, three groups of normal animals receiving different treatments consisting of vehicle, aqueous extract of Parthenium hysterophor...
Published in Indian Journal of Pharmacology
Objective: To study the effect of the methomyl on mixed function oxidase system in rats. Materials and Methods: The effect of the methomyl on mixed function oxidase was studied using different dosages, durations and sex. Microsomes were isolated using the calcium precipitation method. The levels of cytochrome P450 , and cytochrome b5 were determine...
Published in Indian Journal of Pharmacology
Published in Indian Journal of Pharmacology
Objectives: The study was undertaken to evaluate the burn wound healing property of oil of Cocos nucifera and to compare the effect of the combination of oil of Cocos nucifera and silver sulphadiazine with silver sulphadiazine alone. Materials and Methods: Partial thickness burn wounds were inflicted upon four groups of six rats each. Group I was a...
Published in Indian Journal of Pharmacology
Ondansetron is a serotonin receptor antagonist used widely in the prophylaxis and treatment of postoperative nausea and vomiting (PONV) and vomiting associated with cancer chemotherapy. The common side effects of ondansetron are fever, malaise, diarrhoea, constipation, and allergic reactions. Extra-pyramidal reactions are rare and cardiovascular si...
