Monkeypox infection: A quick glance.
Published in Indian journal of pharmacology
Effect of baricitinib in regulating programmed death 1 and ligand programmed cell death ligand 1 through JAK/STAT pathwa...
Published in Indian Journal of Pharmacology
OBJECTIVES: Psoriasis is a chronic infectious skin disease triggered by an autoimmune process involving T-cell-mediated hyper-proliferation of keratinocytes. The objective of this study is to assess the modulation of programmed death 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) through JAK/STAT pathway during the development of a ...
Information on migraine drugs in commonly available Indian drug information sources – Whether we satisfied the community...
Published in Indian Journal of Pharmacology
Drug information can be obtained from various drug information sources that were available as government (National Formulary of India [NFI]; Central Drugs Standard Control Organization [CDSCO]), as well as commercial documents (Current Index of Medical Specialties [CIMS] and Monthly Index of Medical Specialties [MIMS]). Irrational drug usage may ha...
Influence of trazodone on the pharmacodynamics and pharmacokinetics of pioglitazone
Published in Indian Journal of Pharmacology
BACKGROUND: These days, poly pharmacy is very common for the treatment of multiple diseases and majority of drugs were metabolized with CYP 450 enzymes. Diabetes mellitus is such a disorder, which requires continuous therapy for the control of blood glucose concentration. Depression was quite common in diabetic patients. Therefore, multiple drugs r...
Hypertensive urgency in a child with focal epilepsy: Is it sodium valproate induced?
Published in Indian Journal of Pharmacology
Oral zinc-induced vomiting in children with acute gastroenteritis. Should we switch to low-dose zinc?
Published in Indian Journal of Pharmacology
Tert-Butylhydroquinone alleviates insulin resistance and liver steatosis in diabetes
...Published in Indian Journal of Pharmacology
OBJECTIVES: This work aimed to determine tert-Butylhydroquinone (TBHQ)'s effects on insulin resistance (IR) and liver steatosis in diabetic animals and to explore the underpinning mechanisms. MATERIALS AND METHODS: Male ApoE-/-mice underwent streptozocin (STZ) administration while receiving a sucrose/fat-rich diet for type 2 diabetes mellitus (T2DM...
Efficacy of Melaleuca alternifolia and chlorhexidine mouth rinses in reducing oral malodor and Solobacterium moorei leve...
Published in Indian Journal of Pharmacology
OBJECTIVES: The objective is to evaluate the association of Solobacterium moorei ( S. moorei ) to halitosis and to also check for the effects of two different mouth rinses on levels of S. moorei in saliva and tongue coating and its impact on oral halitosis. MATERIALS AND METHODS: This was a placebo-controlled parallel study of 160 individuals who w...
Evaluation of genetic polymorphism of CYP3A5 in normal healthy participants from western India - A cross-sectional study...
Published in Indian Journal of Pharmacology
BACKGROUND: CYP3A5 enzymes belong to the phase I Group of drug-metabolizing enzymes, which are involved in the metabolism of 50% of the drugs. Participants with CYP3A5 genotype: CYP3A5 *1/*1 are fast metabolizers of drugs and hence will require higher dosing. Whereas those with CYP3A5 * 3/*3 are poor metabolizers of drugs and will require a lower d...
Animal models - Mimicking the pain of trigeminal neuralgia
Published in Indian Journal of Pharmacology
Trigeminal neuralgia (TN) is an episodic facial pain which feels like an electric shock of unilateral origin. This neuropathic disorder is an intensely stressful to bear for patient and impacts the quality of life. Most of the cases of TN arise when the root of fifth cranial nerve, i.e., trigeminal nerve is compressed after a few millimeters of its...
