Goldenberg, Joshua E Lentzou, Stergiani Ackert-Smith, Lyn Knowlton, Harrison Dash, Michael B
Published in
Hippocampus
Individuals can use diverse behavioral strategies to navigate their environment including hippocampal-dependent place strategies reliant upon cognitive maps and striatal-dependent response strategies reliant upon egocentric body turns. The existence of multiple memory systems appears to facilitate successful navigation across a wide range of enviro...
Ostrovskaya, Olga I Cao, Guan Eroglu, Cagla Harris, Kristen M
Published in
Hippocampus
Analysis of long-term potentiation (LTP) provides a powerful window into cellular mechanisms of learning and memory. Prior work shows late LTP (L-LTP), lasting >3 hr, occurs abruptly at postnatal day 12 (P12) in the stratum radiatum of rat hippocampal area CA1. The goal here was to determine the developmental profile of synaptic plasticity leading ...
Young, Calvin K Ruan, Ming McNaughton, Neil
Published in
Hippocampus
Theta oscillations in the hippocampus have many behavioral correlates, with the magnitude and vigor of ongoing movement being the most salient. Many consider correlates of locomotion with hippocampal theta to be a confound in delineating theta contributions to cognitive processes. Theory and empirical experiments suggest theta-movement relationship...
Mouchati, Philippe R Kloc, Michelle L Holmes, Gregory L White, Sheryl L Barry, Jeremy M
Published in
Hippocampus
Hippocampal theta oscillations show prominent changes in frequency and amplitude depending on behavioral state or cognitive demands. How these dynamic changes in theta oscillations contribute to the spatial and temporal organization of hippocampal cells, and ultimately behavior, remain unclear. We used low-theta frequency optogenetic stimulation to...
Karimi, Seyed Asaad Hosseinmardi, Narges Sayyah, Mohammad Hajisoltani, Razieh Janahmadi, Mahyar
Published in
Hippocampus
Traumatic brain injury (TBI) is associated with epileptiform activity in the hippocampus; however, the underlying mechanisms have not been fully determined. The goal was to understand what changes take place in intrinsic neuronal physiology in the hippocampus after blunt force trauma to the cortex. In this context, hyperpolarization-activated catio...
Viena, Tatiana D Rasch, Gabriela E Silva, Daniela Allen, Timothy A
Published in
Hippocampus
The midline thalamus bidirectionally connects the medial prefrontal cortex (mPFC) and hippocampus (HC) creating a unique cortico-thalamo-cortical circuit fundamental to memory and executive function. While the anatomical connectivity of midline thalamus has been thoroughly investigated, little is known about its cellular organization within each nu...
Lothmann, Kimberley Deitersen, Jana Zilles, Karl Amunts, Katrin Herold, Christina
Published in
Hippocampus
In rodents, gene-expression, neuronal tuning, connectivity and neurogenesis studies have postulated that the dorsal, the intermediate and the ventral hippocampal formation (HF) are distinct entities. These findings are underpinned by behavioral studies showing a dissociable role of dorsal and ventral HF in learning, memory, stress and emotional pro...
Sabariego, Marta Tabrizi, Nina S Marshall, Greer J McLagan, Ali N Jawad, Safa Hales, Jena B
Published in
Hippocampus
Space and time are both essential features of episodic memory, for which the hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used effectively to study the behavioral relevance of place cells. However, the behavioral paradigms utilized for the study of time cells have not used time duration as a variable that animals nee...
Connolly, Meghan G Yost, Oriana L Potter, Opal V Giedraitis, Megan E Kohman, Rachel A
Published in
Hippocampus
Toll-like receptor 4 (TLR4) is primarily responsible for initiating an immune response following pathogen recognition. However, TLR4 is also expressed on neural progenitor cells and has been reported to regulate hippocampal neurogenesis as young male TLR4 knockout mice show increases in cell proliferation and doublecortin positive cells. Whether th...
Argyropoulos, Georgios P D Butler, Christopher R
Published in
Hippocampus
