De Greef, Daniel Aernouts, Jef Aerts, Johan Cheng, Jeffrey Tao Horwitz, Rachelle Rosowski, John J Dirckx, Joris J J
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Hearing research
A new anatomically-accurate Finite Element (FE) model of the tympanic membrane (TM) and malleus was combined with measurements of the sound-induced motion of the TM surface and the bony manubrium, in an isolated TM-malleus preparation. Using the results, we were able to address two issues related to how sound is coupled to the ossicular chain: (i) ...
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Hearing Research
Abstract Studies of the F344 rat have shown a variety of age-related auditory anatomy and physiology changes. The current study was undertaken to clarify the ARHL in the F344 rat, by examining the auditory pathway of the F344/NHsd substrain that is distributed by Harlan Laboratories for research in the United States. The F344/NHsd rat begins to los...
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Hearing Research
Abstract The transformation of head-movements into neural signals represents a multi-stage process. It depends on orientation and movement of the head, the geometry and mechanics of the vestibular sensors, and the ensuing processing of the peripheral vestibular signals. While this process is well understood for the semicircular canals, where each c...
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Hearing Research
Abstract Temporal envelope processing in the human auditory cortex has an important role in language analysis. In this paper, depth recordings of local field potentials in response to amplitude modulated white noises were used to design maps of activation in primary, secondary and associative auditory areas and to study the propagation of the corti...
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Hearing Research
Abstract The relationship between outer hair cell (OHC) loss and cochlear sensitivity is still unclear, because in many animal models there exist surviving but dysfunctional OHCs and also injured/dead inner hair cells (IHC). Styrene is an ototoxic agent, which targets and destroys OHCs starting from the third row to the second and first rows depend...
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Hearing Research
Abstract Available evidence suggests that sodium salicylate (SS) may produce tinnitus through altering the balance between inhibition and excitation in the central auditory system. Since serotonin (5-hydroxytryptamine, 5-HT) containing fibers preferentially innervate inhibitory GABA neurons, there exists a possibility that SS causes the imbalance b...
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Hearing Research
Abstract Following hair cell elimination in severely traumatized cochleae, differentiated supporting cells are often replaced by a simple epithelium with cuboidal or flat appearance. Atoh1 (previously Math1) is a basic helix–loop–helix transcription factor critical to hair cell differentiation during mammalian embryogenesis. Forced expression of At...
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Hearing Research
Abstract Laser microdissection (LMD) has been used to isolate groups of cells and single cells from numerous tissues. In this study, we describe a technique for isolating cochlear structures and individual spiral ganglion cells from archival celloidin embedded human temporal bone sections. The specimens isolated are suitable for quantifying the mit...
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Hearing Research
Abstract It has been established that current cochlear implants do not supply adequate spectral information for perception of tonal languages. Comprehension of a tonal language, such as Mandarin Chinese, requires recognition of lexical tones. New strategies of cochlear stimulation such as variable stimulation rate and current steering may provide t...
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Hearing Research
Abstract It is generally believed that both sensory immaturity and inattention contribute to the poor listening of some children. However, the relative contribution of each factor, within and between individuals, and the nature of the inattention are poorly understood. In three experiments we examined the threshold and response variability of 6–11 ...
