Published in Hearing Research
Age-related cochlear synaptopathy (CS) has been shown to occur in rodents with minimal noise exposure, and has been hypothesized to play a crucial role in age-related hearing declines in humans. Because CS affects mainly low-spontaneous rate auditory nerve fibers, differential electrophysiological measures such as the ratio of the amplitude of wave...
Published in Hearing research
Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the direct actions of chloroquine on mechanoreceptive hair cells in common experimental models is lacking. This study examines the effects of chloroquine on hair cells using two common experimen...
Published in Hearing research
The underlying causes of age-related hearing loss (ARHL) are not well understood, but it is clear from heritability estimates that genetics plays a role in addition to environmental factors. Genome-wide association studies (GWAS) in human populations can point to candidate genes that may be involved in ARHL, but follow-up analysis is needed to asse...
Published in Hearing research
The relative importance of neural temporal and place coding in auditory perception is still a matter of much debate. The current article is a compilation of viewpoints from leading auditory psychophysicists and physiologists regarding the upper frequency limit for the use of neural phase locking to code temporal fine structure in humans. While phas...
Published in Hearing Research
• Given careful measurement techniques, ABR and EFR amplitudes can be highly reliable. • The same is true of MEMR thresholds and MEMR across-frequency threshold difference. • Differential ABR and EFR measures exhibit only poor-to-moderate reliability. • Correlations between measures are not evident in young people with normal audiograms. • Proxy me...
Published in Hearing research
A common method for measuring changes in temporal processing sensitivity in both humans and animals makes use of GaP-induced Inhibition of the Acoustic Startle (GPIAS). It is also the basis of a common method for detecting tinnitus in rodents. However, the link to tinnitus has not been properly established because GPIAS has not yet been used to obj...
Published in Hearing research
The capacity of the auditory system to extract spatial information relies principally on the detection and interpretation of binaural cues, i.e., differences in the time of arrival or level of the sound between the two ears. In this review, we consider the effects of unilateral or asymmetric hearing loss on spatial hearing, with a focus on the adap...
Published in Hearing research
Previous studies have demonstrated that cochlear implant (CI) patients are more efficient at performing sound categorisation than sound identification. However, it remains unclear how this categorisation capacity develops with time during the rehabilitation period after implantation. To investigate the role of the post-implantation auditory experie...
Published in Hearing Research
•Cochlear implantation via the round window was performed in C57Bl/6 mice.•Cone beam CT and microscopy confirmed implant placement within the scala tympani.•ABR testing revealed a small elevation in thresholds in implanted ears vs. controls.•Encapsulation of the implant in fibrotic-type tissue was observed.
Published in Hearing Research
•Analyses of transgenic mice show substantial central auditory function of deafness genes.•Deafness genes are enriched in the transcriptome of the auditory brainstem.•Shared genetic program during development of peripheral and central auditory system.•Novel sequencing techniques will allow affordable genetic diagnosis.•Knowledge of central auditory...
