Lee, Hyun Sil Gonzalez-Gil, Anabel Drake, Virginia Li, T August Schnaar, Ronald L Kim, Jean
Published in
Glycobiology
Siglec-8, an immune-inhibitory sialoglycan binding lectin (S8), is expressed on the surface of eosinophils and mast cells, which are potent mediators of allergic inflammation. When S8 engages endogenous sialoglycan ligands, eosinophils undergo apoptosis and mast cell mediator release is inhibited. In the human airway, Siglec-8 ligands (S8L) are sia...
Li, Chunxia Palma, Angelina S Zhang, Pengtao Zhang, Yibing Gao, Chao Silva, Lisete M Li, Zhen Trovão, Filipa Weishaupt, Markus Seeberger, Peter H
...
Published in
Glycobiology
Glycan microarrays have played important roles in detection and specificity assignment of glycan recognition by proteins. However, the size and diversity of glycan libraries in current microarray systems are small compared to estimated glycomes, and these may lead to missed detection or incomplete assignment. For microarray construction, covalent a...
Šmak, Pavel Chandrabose, Selvaraj Tvaroška, Igor Koča, Jaroslav
Published in
Glycobiology
Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the globe. The spectrum of disease is broad but among hospitalized patients with COVID-19, respiratory failure from acute respiratory distress syndrome is the leading cause of mortality. There is an urgent need for an effective treatment. The current focus has been developing novel t...
Nikpour, Mahnaz Nilsson, Jonas Persson, Andrea Noborn, Fredrik Vorontsov, Egor Larson, Göran
Published in
Glycobiology
Proteoglycans (PGs) are proteins with glycosaminoglycan (GAG) chains, such as chondroitin sulfate (CS) or heparan sulfate (HS), attached to serine residues. We have earlier shown that prohormones can carry CS, constituting a novel class of PGs. The mapping of GAG modifications of proteins in endocrine cells may thus assist us in delineating possibl...
Dhar, Chirag Sasmal, Aniruddha Diaz, Sandra Verhagen, Andrea Yu, Hai Li, Wanqing Chen, Xi Varki, Ajit
Published in
Glycobiology
Brown, Haley A Koropatkin, Nicole M
Published in
Glycobiology
The Bacteroidetes are numerically abundant Gram-negative organisms of the distal human gut with a greatly expanded capacity to degrade complex glycans. A subset of these are adept at scavenging host glycans within this environment, including mucin O-linked glycans, N-linked glycoproteins and highly sulfated glycosaminoglycans (GAGs) such as heparin...
Agarwal, Kavita Lewis, Amanda L
Published in
Glycobiology
Bacterial vaginosis (BV) is a condition of the vaginal microbiome in which there are few lactobacilli and abundant anaerobic bacteria. Members of the genus Gardnerella are often one of the most abundant bacteria in BV. BV is associated with a wide variety of poor health outcomes for women. It has been recognized since the 1980s that women with BV h...
Low, Kristin E Smith, Steven P Abbott, D Wade Boraston, Alisdair B
Published in
Glycobiology
The gastrointestinal (GI) tract of humans and animals is lined with mucus that serves as a barrier between the gut microbiota and the epithelial layer of the intestine. As the proteins present in mucus are typically heavily glycosylated, such as the mucins, several enteric commensal and pathogenic bacterial species are well-adapted to this rich car...
Bell, Andrew Juge, Nathalie
Published in
Glycobiology
The gut microbiota plays a major role in human health and an alteration in gut microbiota structure and function has been implicated in several diseases. In the colon, mucus covering the epithelium is critical to maintain a homeostatic relationship with the gut microbiota by harboring a microbial community at safe distance from the epithelium surfa...
Jouanneau, Diane Klau, Leesa J Larocque, Robert Jaffrennou, Agathe Duval, Ghislain Le Duff, Nolwen Roret, Thomas Jeudy, Alexandra Aachmann, Finn L Czjzek, Mirjam
...
Published in
Glycobiology
Alginate is a major compound of brown macroalgae and as such an important carbon and energy source for heterotrophic marine bacteria. Despite the rather simple composition of alginate only comprising mannuronate and guluronate units, these bacteria feature complex alginolytic systems that can contain up to seven alginate lyases. This reflects the n...
