Wei, Yu-Miao Li, Xiang Xu, Ming Abais, Justine M. Chen, Yang Riebling, Christopher R. Boini, Krishna M. Li, Pin-Lan Zhang, Yang
Published in
Cellular Physiology and Biochemistry
Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes...
Hopkins, Jessica L Lan, Li Zou, Lee
Published in
Genes & development
DNA repair and DNA damage signaling pathways are critical for the maintenance of genomic stability. Defects of DNA repair and damage signaling contribute to tumorigenesis, but also render cancer cells vulnerable to DNA damage and reliant on remaining repair and signaling activities. Here, we review the major classes of DNA repair and damage signali...
Barry, Raymond Mario Sacco, Olivia Mameri, Amel Stojaspal, Martin Kartsonis, William Shah, Pooja De Ioannes, Pablo Hofr, Ctirad Côté, Jacques Sfeir, Agnel
...
Published in
Genes & development
In mammals, the conserved telomere binding protein Rap1 serves a diverse set of nontelomeric functions, including activation of the NF-kB signaling pathway, maintenance of metabolic function in vivo, and transcriptional regulation. Here, we uncover the mechanism by which Rap1 modulates gene expression. Using a separation-of-function allele, we show...
Weidemann, Benjamin J Bass, Joseph
Published in
Genes & development
In vivo regeneration of β cells provides hope for self-renewal of functional insulin-secreting cells following β-cell failure, a historically fatal condition now sustainable only by administration of exogenous insulin. Despite advances in the treatment of diabetes mellitus, the path toward endogenous renewal of β-cell populations has remained elusi...
Ray, Mukulika Larschan, Erica
Published in
Genes & development
In this issue of Genes & Development, Lu and colleagues (pp. 663-677) have discovered a key new mechanism of alternative promoter choice that is involved in differentiation of spermatocytes. Promoter choice has strong potential as mechanism for differentiation of many different cell types. © 2020 Ray and Larschan; Published by Cold Spring Harbor La...
El-Merahbi, Rabih Viera, Jonathan Trujillo Valdes, Angel Loza Kolczynska, Katarzyna Reuter, Saskia Löffler, Mona C Erk, Manuela Ade, Carsten P Karwen, Till Mayer, Alexander E
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Published in
Genes & development
Obesity-induced diabetes affects >400 million people worldwide. Uncontrolled lipolysis (free fatty acid release from adipocytes) can contribute to diabetes and obesity. To identify future therapeutic avenues targeting this pathway, we performed a high-throughput screen and identified the extracellular-regulated kinase 3 (ERK3) as a hit. We demonstr...
Vizioli, Maria Grazia Liu, Tianhui Miller, Karl N Robertson, Neil A Gilroy, Kathryn Lagnado, Anthony B Perez-Garcia, Arantxa Kiourtis, Christos Dasgupta, Nirmalya Lei, Xue
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Published in
Genes & development
Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable cell cycle arrest and a complex proinflammatory secretome, termed the senescence-associated secretory phenotype (SASP). We recently discovered that cytoplasmic chromatin fragments (CCFs), extru...
Piccolo, Stefano
Published in
Genes & development
Inhibition of CDK7 is a promising strategy for cancer therapy. CDK7 so far has been understood mainly in the context of Pol II-driven transcription. However, how are the roles of CDK7 in the "basal" transcriptional machinery reconciled with the function of CDK7 as inducer of specific transcriptional programs in tumor cells? In this issue of Genes &...
Gable, Dustin L Gaysinskaya, Valeriya Atik, Christine C Talbot, C Conover Jr Kang, Byunghak Stanley, Susan E Pugh, Elizabeth W Amat-Codina, Nuria Schenk, Kara M Arcasoy, Murat O
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Published in
Genes & development
Short telomere syndromes manifest as familial idiopathic pulmonary fibrosis; they are the most common premature aging disorders. We used genome-wide linkage to identify heterozygous loss of function of ZCCHC8, a zinc-knuckle containing protein, as a cause of autosomal dominant pulmonary fibrosis. ZCCHC8 associated with TR and was required for telom...
Wang, Xueyin Long, Yicheng Paucek, Richard D Gooding, Anne R Lee, Thomas Burdorf, Rachel M Cech, Thomas R
Published in
Genes & development
Polycomb-repressive complex 2 (PRC2) is a histone methyltransferase that is critical for regulating transcriptional repression in mammals. Its catalytic subunit, EZH2, is responsible for the trimethylation of H3K27 and also undergoes automethylation. Using mass spectrometry analysis of recombinant human PRC2, we identified three methylated lysine r...
