Montano-Loza, Aldo J Hansen, Bettina E Corpechot, Christophe Roccarina, Davide Thorburn, Douglas Trivedi, Palak Hirschfield, Gideon McDowell, Patrick Poupon, Raoul Dumortier, Jerome
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Published in
Gastroenterology
Primary biliary cholangitis (PBC) frequently recurs after liver transplantation. We evaluated risk factors associated with recurrence of PBC and its effects on patient and graft survival in a multicenter, international cohort (the Global PBC Study Group). We collected demographic and clinical data from 785 patients (89% female) with PBC who underwe...
Greten, Tim F Lai, Chunwei Walter Li, Guangfu Staveley-O'Carroll, Kevin F
Published in
Gastroenterology
Treatment options for patients with hepatocellular carcinoma are rapidly changing based on positive results from phase 3 trials of targeted and immune-based therapies. More agents designed to target specific pathways and immune checkpoints are in clinical development. Some agents have already been shown to improve outcomes of patients with hepatoce...
Liang, T Jake Terrault, Norah
Published in
Gastroenterology
Bernard, Vincent Kim, Dong U San Lucas, F Anthony Castillo, Jonathan Allenson, Kelvin Mulu, Feven C Stephens, Bret M Huang, Jonathan Semaan, Alexander Guerrero, Paola A
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Published in
Gastroenterology
We aimed to investigate the clinical utility of circulating tumor cell DNA (ctDNA) and exosome DNA (exoDNA) in pancreatic cancer. We collected liquid biopsy samples from 194 patients undergoing treatment for localized or metastatic pancreatic adenocarcinoma from April 7, 2015, through October 13, 2017 (425 blood samples collected before [baseline] ...
Koh, Christopher Heller, Theo Glenn, Jeffrey S
Published in
Gastroenterology
Hepatitis delta virus (HDV) infection of humans was first reported in 1977, and now it is now estimated that 15-20 million people are infected worldwide. Infection with HDV can be an acute or chronic process that occurs only in patients with an hepatitis B virus infection. Chronic HDV infection commonly results in the most rapidly progressive form ...
Braillon, Alain
Published in
Gastroenterology
Zhang, Qiuyang Agoston, Agoston T Pham, Thai H Zhang, Wei Zhang, Xi Huo, Xiaofang Peng, Sui Bajpai, Manisha Das, Kiron Odze, Robert D
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Published in
Gastroenterology
Metaplastic glands buried under squamous epithelium are frequently detected in patients with Barrett esophagus (BE). This subsquamous intestinal metaplasia might be responsible for cancers that develop despite endoscopic surveillance and for metaplasia recurrences after endoscopic ablation. To determine whether reflux induces BE cells to undergo an...
Hao, Lu Li, Zhao-Shen Hu, Liang-Hao
Published in
Gastroenterology
Bailey, Justin R. Barnes, Eleanor Cox, Andrea L.
Published in
Gastroenterology
Risk factors for hepatitis C virus (HCV) infection vary, and there were an estimated 1.75 million new cases worldwide in 2015. The World Health Organization aims for a 90% reduction in new HCV infections by 2030. An HCV vaccine would prevent transmission, regardless of risk factors, and significantly reduce the global burden of HCV-associated disea...
McNaughton, Anna L D'Arienzo, Valentina Ansari, M Azim Lumley, Sheila F Littlejohn, Margaret Revill, Peter McKeating, Jane A Matthews, Philippa C
Published in
Gastroenterology
Hepatitis B virus (HBV) is a unique, tiny, partially double-stranded, reverse-transcribing DNA virus with proteins encoded by multiple overlapping reading frames. The substitution rate is surprisingly high for a DNA virus, but lower than that of other reverse transcribing organisms. More than 260 million people worldwide have chronic HBV infection,...
