Streptococcus gallolyticus Bacteremia and Colorectal Carcinoma.
Published in Gastroenterology
Modifiable Failures in the Colorectal Cancer Screening Process and Their Association With Risk of Death.
...Published in Gastroenterology
Colorectal cancer (CRC) deaths occur when patients do not receive screening or have inadequate follow-up of abnormal results or when the screening test fails. We have few data on the contribution of each to CRC-associated deaths or factors associated with these events. We performed a retrospective cohort study of patients in the Kaiser Permanente N...
Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome.
Published in Gastroenterology
The existence of postinfection irritable bowel syndrome (PI-IBS) has been substantiated by epidemiology studies conducted in diverse geographic and clinical settings. However, the available evidence has not been well summarized, and there is little guidance for diagnosis and treatment of PI-IBS. The ROME Foundation has produced a working team repor...
Status of Direct-acting Antiviral Therapy for HCV Infection and Remaining Challenges
Published in Gastroenterology
Chronic infection with hepatitis C virus (HCV) is a major cause of liver disease and hepatocellular carcinoma worldwide. Following the discovery of HCV 3 decades ago, the identification of the structure of the viral proteins, combined with high-throughput replicon models, enabled the discovery and development of direct-acting antivirals. These agen...
Is Elimination of Hepatitis B and C a Pipe Dream or Reality?
Published in Gastroenterology
Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis.
...Published in Gastroenterology
Nonalcoholic steatohepatitis (NASH) is a leading cause of liver transplantation, and many trials are underway to evaluate potential therapies. The farnesoid X receptor ligand obeticholic acid in the NASH treatment trial evaluated the effects of obeticholic acid vs placebo on histologic response (defined as decrease in nonalcoholic fatty liver disea...
Persistence of Pathogenic B-Cell Clones and Relapse of Cryoglobulinemic Vasculitis in HCV-Cured Patients.
Published in Gastroenterology
Tropism for Spasmolytic Polypeptide-Expressing Metaplasia Allows Helicobacter pylori to Expand Its Intragastric Niche.
Published in Gastroenterology
In patients with chronic Helicobacter pylori (H pylori) infection, parietal and chief cell atrophy in the gastric corpus, a process known as spasmolytic polypeptide-expressing metaplasia (SPEM), increases the risk for progression to cancer. The relation between H pylori and these metaplastic changes is unclear. We investigated whether H pylori loca...
Cell and Animal Models for Studying Hepatitis B Virus Infection and Drug Development.
Published in Gastroenterology
Many cell culture and animal models have been used to study hepatitis B virus (HBV) replication and its effects in the liver; these have facilitated development of strategies to control and clear chronic HBV infection. We discuss the advantages and limitations of systems for studying HBV and developing antiviral agents, along with recent advances. ...
Early Liver Transplantation for Alcoholic Hepatitis.
Published in Gastroenterology
