Andersson, Emma R Chivukula, Indira V Hankeova, Simona Sjöqvist, Marika Tsoi, Yat Long Ramsköld, Daniel Masek, Jan Elmansuri, Aiman Hoogendoorn, Anita Vazquez, Elenae
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Published in
Gastroenterology
Alagille syndrome is a genetic disorder characterized by cholestasis, ocular abnormalities, characteristic facial features, heart defects, and vertebral malformations. Most cases are associated with mutations in JAGGED1 (JAG1), which encodes a Notch ligand, although it is not clear how these contribute to disease development. We aimed to develop a ...
Li, Tao Hao, Chun-Yan Zhang, Zong-Li
Published in
Gastroenterology
Trépo, Eric Goossens, Nicolas Fujiwara, Naoto Song, Won-Min Colaprico, Antonio Marot, Astrid Spahr, Laurent Demetter, Pieter Sempoux, Christine Im, Gene Y.
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Published in
Gastroenterology
Background & Aims Patients with severe alcoholic hepatitis (AH) have a high risk of death within 90 days. Corticosteroids, which can cause severe adverse events, are the only treatment that increases short-term survival. It is a challenge to predict outcomes of patients with severe AH. Therefore, we developed a scoring system to predict patient sur...
Wong, Shenq-Jie
Published in
Gastroenterology
Weinberg, David S Pickhardt, Perry J Bruining, David H Edwards, Kristin Fletcher, Joel G Gollub, Marc J Keenan, Eileen M Kupfer, Sonia S Li, Tianyu Lubner, Sam J
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Published in
Gastroenterology
Recommendations for surveillance after curative surgery for colorectal cancer (CRC) include a 1-year post-resection abdominal-pelvic computed tomography (CT) scan and optical colonoscopy (OC). CT colonography (CTC), when used in CRC screening, effectively identifies colorectal polyps ≥10 mm and cancers. We performed a prospective study to determine...
Naganuma, Makoto Sugimoto, Shinya Mitsuyama, Keiichi Kobayashi, Taku Yoshimura, Naoki Ohi, Hidehisa Tanaka, Shinji Andoh, Akira Ohmiya, Naoki Saigusa, Keiichiro
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Published in
Gastroenterology
Indigo naturalis (IN) is a traditional Chinese medicine that contains ligands for the aryl hydrocarbon receptor and promotes regeneration of the mucosa by inducing production of interleukin 22. IN might induce mucosal healing in patients with ulcerative colitis (UC). We performed a randomized controlled trial to investigate the safety and efficacy ...
Vege, Santhi Swaroop DiMagno, Matthew J Forsmark, Chris E Martel, Myriam Barkun, Alan N
Published in
Gastroenterology
Llewellyn, Sean R Britton, Graham J Contijoch, Eduardo J Vennaro, Olivia H Mortha, Arthur Colombel, Jean-Frederic Grinspan, Ari Clemente, Jose C Merad, Miriam Faith, Jeremiah J
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Published in
Gastroenterology
It is not clear how the complex interactions between diet and the intestinal microbiota affect development of mucosal inflammation or inflammatory bowel disease. We investigated interactions between dietary ingredients, nutrients, and the microbiota in specific pathogen-free (SPF) and germ-free (GF) mice given more than 40 unique diets; we quantifi...
Dietz, Julia Susser, Simone Vermehren, Johannes Peiffer, Kai-Henrik Grammatikos, Georgios Berger, Annemarie Ferenci, Peter Buti, Maria Müllhaupt, Beat Hunyady, Bela
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Published in
Gastroenterology
Little is known about substitutions that mediate resistance of hepatitis C virus (HCV) to direct-acting antivirals (DAAs), due to the small number of patients with treatment failure in approval studies. It is important to identify resistance patterns to select effective salvage treatments. We performed a comprehensive analysis for resistance-associ...
Tirosh, Amit Papadakis, Georgios Z Millo, Corina Hammoud, Dima Sadowski, Samira M Herscovitch, Peter Pacak, Karel Marx, Stephen J Yang, Lily Nockel, Pavel
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Published in
Gastroenterology
Survival times vary among patients with neuroendocrine tumors (NETs) - even among those with the same site, stage, and grade of primary tumor. This makes it difficult to select treatment for patients with unresectable NETs because some patients can survive decades without treatment. 68Gallium-DOTATATE positron emission tomography with computed tomo...