Tsui, Jennifer Schwartz, Neil Ruthazer, Edward S.
Published in
Frontiers in Synaptic Neuroscience
The retinotectal projection in Xenopus laevis has been shown to exhibit correlation-based refinement of both anatomical and functional connectivity during development. Spike timing-dependent plasticity (STDP) is an appealing experimental model for correlation-based synaptic plasticity because, in contrast to plasticity induction paradigms using tet...
Buchanan, Katherine A. Mellor, Jack R.
Published in
Frontiers in Synaptic Neuroscience
Synaptic plasticity has historically been investigated most intensely in the hippocampus and therefore it is somewhat surprising that the majority of studies on spike timing-dependent plasticity (STDP) have focused not in the hippocampus but on synapses in the cortex. One of the major reasons for this bias is the relative ease in obtaining paired e...
Safiulina, Victoria F. Caiati, Maddalena D. Sivakumaran, Sudhir Bisson, Giacomo Migliore, Michele Cherubini, Enrico
Published in
Frontiers in Synaptic Neuroscience
In this review some of the recent work carried out in our laboratory concerning the functional role of GABAergic signalling at immature mossy fibres (MF)-CA3 principal cell synapses has been highlighted. While in adulthood MF, the axons of dentate gyrus granule cells release onto CA3 principal cells and interneurons glutamate, early in postnatal li...
Panzeri, Stefano Diamond, Mathew E.
Published in
Frontiers in Synaptic Neuroscience
Computational analyses have revealed that precisely timed spikes emitted by somatosensory cortical neuronal populations encode basic stimulus features in the rat's whisker sensory system. Efficient spike time based decoding schemes both for the spatial location of a stimulus and for the kinetic features of complex whisker movements have been define...
Watt, Alanna J. Desai, Niraj S.
Published in
Frontiers in Synaptic Neuroscience
Spike-timing-dependent plasticity (STDP) offers a powerful means of forming and modifying neural circuits. Experimental and theoretical studies have demonstrated its potential usefulness for functions as varied as cortical map development, sharpening of sensory receptive fields, working memory, and associative learning. Even so, it is unlikely that...
Lamsa, Karri P. Kullmann, Dimitri M. Woodin, Melanie A.
Published in
Frontiers in Synaptic Neuroscience
Inhibitory circuits in the brain rely on GABA-releasing interneurons. For long, inhibitory circuits were considered weakly plastic in the face of patterns of neuronal activity that trigger long-term changes in the synapses between excitatory principal cells. Recent studies however have shown that GABAergic circuits undergo various forms of long-ter...
Garay, Paula A. McAllister, A. Kimberley
Published in
Frontiers in Synaptic Neuroscience
Although the brain has classically been considered “immune-privileged”, current research suggests an extensive communication between the immune and nervous systems in both health and disease. Recent studies demonstrate that immune molecules are present at the right place and time to modulate the development and function of the healthy and diseased ...
Butts, Daniel A. Kanold, Patrick O.
Published in
Frontiers in Synaptic Neuroscience
Spike time dependent plasticity (STDP) has been observed in both developing and adult animals. Theoretical studies suggest that it implicitly leads to both competition and homeostasis in addition to correlation-based plasticity, making it a good candidate to explain developmental refinement and plasticity in a number of systems. However, it has onl...
Gerstner, Wulfram
Published in
Frontiers in Synaptic Neuroscience
Clopath, Claudia Gerstner, Wulfram
Published in
Frontiers in Synaptic Neuroscience
A phenomenological model of synaptic plasticity is able to account for a large body of experimental data on spike-timing-dependent plasticity (STDP). The basic ingredient of the model is the correlation of presynaptic spike arrival with postsynaptic voltage. The local membrane voltage is used twice: a first term accounts for the instantaneous volta...
