Kalmbach, Abigail Kullmann, Paul H. M. Kandler, Karl
Published in
Frontiers in Synaptic Neuroscience
Before hearing onset, the topographic organization of the inhibitory sound localization pathway from the medial nucleus of the trapezoid body (MNTB) to the lateral superior olive (LSO) is refined by means of synaptic silencing and strengthening. During this refinement period MNTB-LSO synapses not only release GABA and glycine but also release gluta...
Schulz, Jan M. Redgrave, Peter Reynolds, John N. J.
Published in
Frontiers in Synaptic Neuroscience
Cortico-striatal spike-timing dependent plasticity (STDP) is modulated by dopamine in vitro. The present study investigated STDP in vivo using alternative procedures for modulating dopaminergic inputs. Postsynaptic potentials (PSP) were evoked in intracellularly recorded spiny neurons by electrical stimulation of the contralateral motor cortex. PSP...
Testa-Silva, Guilherme Verhoog, Matthijs B. Goriounova, Natalia A. Loebel, Alex Hjorth, Johannes Baayen, Johannes C. de Kock, Christiaan P. J. Mansvelder, Huibert D.
Published in
Frontiers in Synaptic Neuroscience
Throughout our lifetime, activity-dependent changes in neuronal connection strength enable the brain to refine neural circuits and learn based on experience. Synapses can bi-directionally alter strength and the magnitude and sign depend on the millisecond timing of presynaptic and postsynaptic action potential firing. Recent findings on laboratory ...
Brown, Jon T. Weatherall, Kate L. Corria, Laura R. Chater, Thomas E. Isaac, John T. Marrion, Neil V.
Published in
Frontiers in Synaptic Neuroscience
Glutamate is released from synaptic vesicles following formation of a fusion pore, connecting the vesicle interior with the synaptic cleft. Release is proposed to result from either full fusion of the vesicle with the terminal membrane or by ‘kiss-and-run,’ where release occurs through the fusion pore. ‘Kiss-and-run’ seems implausible as passive di...
Oberman, Lindsay Ifert-Miller, Fritz Najib, Umer Bashir, Shahid Woollacott, Ione Gonzalez-Heydrich, Joseph Picker, Jonathan Rotenberg, Alexander Pascual-Leone, Alvaro
Published in
Frontiers in Synaptic Neuroscience
Fragile X Syndrome (FXS) is the most common heritable cause of intellectual disability. In vitro electrophysiologic data from mouse models of FXS suggest that loss of fragile X mental retardation protein affects intracortical excitability and synaptic plasticity. Specifically, the cortex appears hyperexcitable, and use-dependent long-term potentiat...
Balena, Trevor Acton, Brooke A. Woodin, Melanie A.
Published in
Frontiers in Synaptic Neuroscience
Coincident pre- and postsynaptic activity of hippocampal neurons alters the strength of gamma-aminobutyric acid (GABAA)-mediated inhibition through a Ca2+-dependent regulation of cation-chloride cotransporters. This long-term synaptic modulation is termed GABAergic spike-timing dependent plasticity (STDP). In the present study, we examined whether ...
Fdez, Elena Hilfiker, Sabine
Published in
Frontiers in Synaptic Neuroscience
Nishiyama, Makoto Togashi, Kazunobu Aihara, Takeshi Hong, Kyonsoo
Published in
Frontiers in Synaptic Neuroscience
GABAergic interneuronal network activities in the hippocampus control a variety of neural functions, including learning and memory, by regulating θ and γ oscillations. How these GABAergic activities at pre- and postsynaptic sites of hippocampal CA1 pyramidal cells differentially contribute to synaptic function and plasticity during their repetitive...
Lamsa, Karri P. Kullmann, Dimitri M. Woodin, Melanie A.
Published in
Frontiers in Synaptic Neuroscience
Inhibitory circuits in the brain rely on GABA-releasing interneurons. For long, inhibitory circuits were considered weakly plastic in the face of patterns of neuronal activity that trigger long-term changes in the synapses between excitatory principal cells. Recent studies however have shown that GABAergic circuits undergo various forms of long-ter...
Debanne, Dominique Poo, Mu-Ming
Published in
Frontiers in Synaptic Neuroscience
Long-lasting plasticity of synaptic transmission is classically thought to be the cellular substrate for information storage in the brain. Recent data indicate however that it is not the whole story and persistent changes in the intrinsic neuronal excitability have been shown to occur in parallel to the induction of long-term synaptic modifications...
