Regulation of AMPA Receptors, From the Genetic to the Functional Level
Published in Frontiers in Synaptic Neuroscience
Published in Frontiers in Synaptic Neuroscience
Published in Frontiers in Synaptic Neuroscience
Acute regulation of CO2 and pH homeostasis requires sensory feedback from peripheral (carotid body) and central (central) CO2/pH sensitive cells – so called respiratory chemoreceptors. Subsets of brainstem serotonin (5-HT) neurons in the medullary raphe are CO2 sensitive or insensitive based on differences in embryonic origin, suggesting these func...
Published in Frontiers in Synaptic Neuroscience
Intellectual disabilities are a type of neurodevelopmental disease caused by neurological dysfunction. Their incidence is largely associated with neural development. Astrocytes are the most widely distributed cells in the mammalian brain. Previous studies have reported that astrocytes only supported and separated the neurons in the brain. However, ...
Published in Frontiers in Synaptic Neuroscience
Published in Frontiers in Synaptic Neuroscience
Published in Frontiers in Synaptic Neuroscience
Inhibitory signaling in the brain organizes the neural circuits that orchestrate how living creatures interact with the world around them and how they build representations of objects and ideas. Without tight control at multiple points of cellular engagement, the brain’s inhibitory systems would run down and the ability to extract meaningful inform...
Published in Frontiers in Synaptic Neuroscience
The general mechanism of calcium-triggered chemical transmitter release from neuronal synapses has been intensely studied, is well-known, and highly conserved between species and synapses across the nervous system. However, the structural and functional details within each transmitter release site (or active zone) are difficult to study in living t...
Published in Frontiers in Synaptic Neuroscience
Published in Frontiers in Synaptic Neuroscience
Published in Frontiers in Synaptic Neuroscience
SHANK3 is a scaffolding protein implicated in autism spectrum disorders (ASD). Its function at excitatory glutamatergic synapses has been studied for the last two decades, however, tissue-specific expression patterns as well as its subcellular localization need to be studied in further detail. Especially the close sequence homology of SHANK3 to its...