Deng, Yuanfei Yu, Cuifu Chen, Lushi Zhang, Xin Lei, Qiucheng Liu, Qing Cai, Gengxi Liu, Fang
Published in
Frontiers in Pharmacology
Hepatocellular carcinoma (HCC) is the most commonly diagnosed liver cancer with limited treatment options and extremely poor prognosis worldwide. Recently, the proteolysis targeting chimeras (PROTACs), which aim to induce proteasome-mediated degradation of interesting proteins via recruiting E3 ligases, have become the advanced tools and attractive...
Hayes, Kaleen N. Mor, Vincent Zullo, Andrew R.
Published in
Frontiers in Pharmacology
Large healthcare administrative databases, like Medicare claims, are a common means to evaluate drug policies. However, administrative data often have a lag time of months to years before they are available to researchers and decision-makers. Therefore, administrative data are not always ideal for timely policy evaluations. Other sources of data ar...
Huang, Zoufang Sharma, Mohit Dave, Aparna Yang, Yuqi Chen, Zhe-Sheng Radhakrishnan, Raghu
Published in
Frontiers in Pharmacology
Liu, Liming Xu, Yue Su, Zihan Man, Xiaowei Jiang, Yan Zhao, Liying Cheng, Wei
Published in
Frontiers in Pharmacology
Background: Danhong injection (DHI) accounts for the highest proportion of drug costs for inpatients with coronary heart disease (CHD). However, if DHI price influences utilization remains unclear. Objective: The objective was to compare changes in the use of DHI for CHD patients during three stages after two comprehensive reforms of public hospita...
Piccialli, Ilaria Tedeschi, Valentina Caputo, Lucia D’Errico, Stefano Ciccone, Roselia De Feo, Vincenzo Secondo, Agnese Pannaccione, Anna
Published in
Frontiers in Pharmacology
Alzheimer’s disease (AD) is a chronic, complex neurodegenerative disorder mainly characterized by the irreversible loss of memory and cognitive functions. Different hypotheses have been proposed thus far to explain the etiology of this devastating disorder, including those centered on the Amyloid-β (Aβ) peptide aggregation, Tau hyperphosphorylation...
Song, Chao Yuan, Yue Zhou, Jing He, Ziliang Hu, Yeye Xie, Yuan Liu, Nan Wu, Lei Zhang, Ji
Published in
Frontiers in Pharmacology
Ginsenoside Rh2 (G-Rh2), a rare protopanaxadiol (PPD)-type triterpene saponin, from Panax ginseng has anti-proliferation, anti-invasion, and anti-metastatic activity. However, the mechanisms by which G-Rh2 induces apoptosis of lung cancer cells are unclear. In the present work, a G-Rh2 target-lung cancer network was constructed and analyzed by the ...
Wang, Pengcheng Wang, Xianwei Liu, Xing Sun, Meng Liang, Xiao Bai, Juan Jiang, Ping
Published in
Frontiers in Pharmacology
Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus (α-CoV) that causes high mortality in suckling piglets, leading to severe economic losses worldwide. No effective vaccine or commercial antiviral drug is readily available. Several replicative enzymes are responsible for coronavirus replication. In this study, the potential candidates ta...
Wang, Yuntao Liu, Yi Li, Xiaohua Li, Weiming Xue, Zhihong He, Xiaoqian Xiong, Weijie He, Lang Bai, Yifeng
Published in
Frontiers in Pharmacology
Background: Lung cancer has the highest morbidity and mortality rate among types of malignant tumors, and as such, research into prolonging the survival time of patients is vital. The emergence of immune checkpoint inhibitors (ICIs) has greatly improved the survival of patients with non-small cell lung cancer (NSCLC), however, the lack of effective...
Aximujiang, Kasimujiang Kaheman, Kuerbannaimu Wushouer, Xilinguli Wu, Guixia Ahemaiti, Abulaiti Yunusi, Kurexi
Published in
Frontiers in Pharmacology
Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease with complex pathogenesis. The intestinal flora disturbance affects the homeostasis of the intestinal environment, leading to metabolic imbalance and immune abnormalities of the host, contributing to the perpetuation of intestinal inflammation. We suggest that the combinat...
Zhao, Hong Li, Wanling Li, Junsheng Li, Li Wang, Hang Guo, Jianming
Published in
Frontiers in Pharmacology
Purpose: The aim of the study was to use machine learning methods (MLMs) to predict the stone-free status after percutaneous nephrolithotomy (PCNL). We compared the performance of this system with Guy’s stone score and the S.T.O.N.E score system. Materials and Methods: Data from 222 patients (90 females, 41%) who underwent PCNL at our center were u...
