Sun, Can Fu, Jian Qu, Zhenzhen Jia, Lijing Li, Dongxiao Zhen, Junli Wang, Weiping
Published in
Frontiers in Molecular Neuroscience
Epilepsy is a complex neurological disorder with frequent psychiatric, cognitive, and social comorbidities in addition to recurrent seizures. Cognitive impairment, one of the most common comorbidities, has severe adverse effects on quality of life. Chronic intermittent hypobaric hypoxia (CIHH) has demonstrated neuroprotective efficacy in several ne...
Vastagh, Csaba Csillag, Veronika Solymosi, Norbert Farkas, Imre Liposits, Zsolt
Published in
Frontiers in Molecular Neuroscience
Rising serum estradiol triggers the surge release of gonadotropin-releasing hormone (GnRH) at late proestrus leading to ovulation. We hypothesized that proestrus evokes alterations in peptidergic signaling onto GnRH neurons inducing a differential expression of neuropeptide-, growth factor-, and orphan G-protein-coupled receptor (GPCR) genes. Thus,...
Wakabayashi, Tomoko
Published in
Frontiers in Molecular Neuroscience
Neuromuscular development is a multistep process and involves interactions among various extracellular and transmembrane molecules that facilitate the precise targeting of motor axons to synaptogenic regions of the target muscle. Collagenous proteins with transmembrane domains have recently emerged as molecules that play essential roles in multiple...
Gao, Yan Nicolson, Teresa
Published in
Frontiers in Molecular Neuroscience
The lipid phosphatase synaptojanin 1 (synj1) is required for the disassembly of clathrin coats on endocytic compartments. In neurons such activity is necessary for the recycling of endocytosed membrane into synaptic vesicles. Mutations in zebrafish synj1 have been shown to disrupt the activity of ribbon synapses in sensory hair cells. After prolong...
Zhang, Shen-Qing Cao, Long-Long Liang, Yun-Yue Wang, Pu
Published in
Frontiers in Molecular Neuroscience
Clinical studies have found that some Alzheimer’s disease (AD) patients suffer from Cushing’s syndrome (CS). CS is caused by the long-term release of excess glucocorticoids (GCs) from the adrenal gland, which in turn, impair brain function and induce dementia. Thus, we investigated the mechanism of the effect of corticosterone (CORT) on the develop...
Kumar, Sathish Kapadia, Akshay Theil, Sandra Joshi, Pranav Riffel, Florian Heneka, Michael T. Walter, Jochen
Published in
Frontiers in Molecular Neuroscience
Aggregation and deposition of amyloid-β (Aβ) peptides in extracellular plaques and in the cerebral vasculature are prominent neuropathological features of Alzheimer’s disease (AD) and closely associated with the pathogenesis of AD. Amyloid plaques in the brains of most AD patients and transgenic mouse models exhibit heterogeneity in the composition...
Cieślik, Magdalena Gassowska-Dobrowolska, Magdalena Zawadzka, Aleksandra Frontczak-Baniewicz, Małgorzata Gewartowska, Magdalena Dominiak, Agnieszka Czapski, Grzegorz A. Adamczyk, Agata
Published in
Frontiers in Molecular Neuroscience
Maternal immune activation (MIA) is a risk factor for neurodevelopmental disorders in offspring, but the pathomechanism is largely unknown. The aim of our study was to analyse the molecular mechanisms contributing to synaptic alterations in hippocampi of adolescent rats exposed prenatally to MIA. MIA was evoked in pregnant female rats by i.p. admin...
Oberstein, Timo Jan Utz, Janine Spitzer, Philipp Klafki, Hans Wolfgang Wiltfang, Jens Lewczuk, Piotr Kornhuber, Johannes Maler, Juan Manuel
Published in
Frontiers in Molecular Neuroscience
Astrocytes may not only be involved in the clearance of Amyloid beta peptides (Aβ) in Alzheimer's disease (AD), but appear to produce N-terminally truncated Aβ (Aβn−x) independently of BACE1, which generates the N-Terminus of Aβ starting with Asp1 (Aβ1−x). A candidate protease for the generation of Aβn−x is cathepsin B (CatB), especially since CatB...
Jin, Chunmei Kang, Hyojin Yoo, Taesun Ryu, Jae Ryun Yoo, Ye-Eun Ma, Ruiying Zhang, Yinhua Kang, Hyae Rim Kim, Yoonhee Seong, Hyunyoung
...
Published in
Frontiers in Molecular Neuroscience
Variants of the SH3 and multiple ankyrin repeat domains 3 ( SHANK3 ), which encodes postsynaptic scaffolds, are associated with brain disorders. The targeted alleles in a few Shank3 knock-out (KO) lines contain a neomycin resistance (Neo) cassette, which may perturb the normal expression of neighboring genes; however, this has not been investigated...
O’Carroll, Simon J. Cook, William H. Young, Deborah
Published in
Frontiers in Molecular Neuroscience
Different glial cell types are found throughout the central (CNS) and peripheral nervous system (PNS), where they have important functions. These cell types are also involved in nervous system pathology, playing roles in neurodegenerative disease and following trauma in the brain and spinal cord (astrocytes, microglia, oligodendrocytes), nerve dege...
