Vanaveski, Taavi Molchanova, Svetlana Pham, Dan Duc Schäfer, Annika Pajanoja, Ceren Narvik, Jane Srinivasan, Vignesh Urb, Mari Koivisto, Maria Vasar, Eero
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Published in
Frontiers in Molecular Neuroscience
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a master regulator of mitochondria biogenesis and cell stress playing a role in metabolic and degenerative diseases. In the brain PGC-1α expression has been localized mainly to GABAergic interneurons but its overall role is not fully understood. We observed here that the protei...
Satta, Valentina Alonso, Cristina Díez, Paula Martín-Suárez, Soraya Rubio, Marta Encinas, Juan M. Fernández-Ruiz, Javier Sagredo, Onintza
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Frontiers in Molecular Neuroscience
Dravet syndrome (DS) is an epileptic syndrome caused by mutations in the Scn1a gene encoding the α1 subunit of the sodium channel Nav1.1, which is associated with febrile seizures that progress to severe tonic-clonic seizures and associated comorbidities. Treatment with cannabidiol has been approved to reduce seizures in DS, but it may also be acti...
Lange, Christian Bifari, Francesco
Published in
Frontiers in Molecular Neuroscience
Morris, Sarah L. Tsai, Ming-Ying Aloe, Sarah Bechberger, Karin König, Svenja Morfini, Gerardo Brady, Scott T.
Published in
Frontiers in Molecular Neuroscience
Tau protein is subject to phosphorylation by multiple kinases at more than 80 different sites. Some of these sites are associated with tau pathology and neurodegeneration, but other sites are modified in normal tau as well as in pathological tau. Although phosphorylation of tau at residues in the microtubule-binding repeats is thought to reduce tau...
Balakrishnan, Anjali Belfiore, Lauren Chu, Tak-Ho Fleming, Taylor Midha, Rajiv Biernaskie, Jeff Schuurmans, Carol
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Frontiers in Molecular Neuroscience
Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self-repair, lifelong disability is common. New molecular and cellular insights have begun to reveal why the peripheral nerve has limited repair capacity. The peripheral nerve...
Cattaneo, Stefano Verlengia, Gianluca Marino, Pietro Simonato, Michele Bettegazzi, Barbara
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Frontiers in Molecular Neuroscience
Neuropeptide Y (NPY) is a neuropeptide abundantly expressed in the mammalian central and peripheral nervous system. NPY is a pleiotropic molecule, which influences cell proliferation, cardiovascular and metabolic function, pain and neuronal excitability. In the central nervous system, NPY acts as a neuromodulator, affecting pathways that range from...
Li Puma, Domenica Donatella Piacentini, Roberto Grassi, Claudio
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Frontiers in Molecular Neuroscience
Adult hippocampal neurogenesis is a physiological mechanism contributing to hippocampal memory formation. Several studies associated altered hippocampal neurogenesis with aging and Alzheimer's disease (AD). However, whether amyloid-β protein (Aβ)/tau accumulation impairs adult hippocampal neurogenesis and, consequently, the hippocampal circuitry, i...
Liu, Junhao Li, Ruoyao Huang, Zucheng Lin, Junyu Ji, Wei Huang, Zhiping Liu, Qi Wu, Xiaoliang Wu, Xiuhua Jiang, Hui
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Frontiers in Molecular Neuroscience
Protecting white matter is one of the key treatment strategies for spinal cord injury (SCI), including alleviation of myelin loss and promotion of remyelination. Rapamycin has been shown neuroprotective effects against SCI and cardiotoxic effects while enhancing autophagy. However, specific neuroprotection of rapamycin for the white matter after ce...
Ando, Kunie Houben, Sarah Homa, Mégane de Fisenne, Marie-Ange Potier, Marie-Claude Erneux, Christophe Brion, Jean-Pierre Leroy, Karelle
Published in
Frontiers in Molecular Neuroscience
Ge, Hongfei Zhang, Chao Yang, Yang Chen, Weixiang Zhong, Jun Fang, Xuanyu Jiang, Xuheng Tan, Liang Zou, Yongjie Hu, Rong
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Published in
Frontiers in Molecular Neuroscience
Ischemic stroke has been becoming one of the leading causes resulting in mortality and adult long-term disability worldwide. Post-stroke pneumonia is a common complication in patients with ischemic stroke and always associated with 1-year mortality. Though ambroxol therapy often serves as a supplementary treatment for post-stroke pneumonia in ische...
