Oliva, Francesco Musiani, Francesco Giorgetti, Alejandro De Rubeis, Silvia Sorokina, Oksana Armstrong, Douglas J. Carloni, Paolo Ruggerone, Paolo
Published in
Frontiers in Chemistry
The seamless integration of human disease-related mutation data into protein structures is an essential component of any attempt to correctly assess the impact of the mutation. The key step preliminary to any structural modelling is the identification of the isoforms onto which mutations should be mapped due to there being several functionally diff...
Chen, Peng-Yu Han, Lin-Tao
Published in
Frontiers in Chemistry
Liu, Yan Qiao, Weicang Liu, Yanpin Zhao, Junying Liu, Qian Yang, Kai Zhang, Minghui Wang, Yaling Liu, Yan Chen, Lijun
...
Published in
Frontiers in Chemistry
Human milk lipids, which are an important source of energy and affect growth and development of infants, require a comprehensive method for its qualitative and quantitative analysis. This work describes a method for the analysis of phospholipids, glycerides, free fatty acids and gangliosides in human milk by ultra-performance liquid chromatography ...
Ikeda, Kazuyoshi Maezawa, Yuta Yonezawa, Tomoki Shimizu, Yugo Tashiro, Toshiyuki Kanai, Satoru Sugaya, Nobuyoshi Masuda, Yoshiaki Inoue, Naoko Niimi, Tatsuya
...
Published in
Frontiers in Chemistry
Protein–protein interactions (PPIs) are recognized as important targets in drug discovery. The characteristics of molecules that inhibit PPIs differ from those of small-molecule compounds. We developed a novel chemical library database system (DLiP) to design PPI inhibitors. A total of 32,647 PPI-related compounds are registered in the DLiP. It con...
Freitas, Camila Auad Beltrão de Costa, Clauber Henrique Souza da Costa, Kauê Santana da Paz, Simone Patrícia Aranha Silva, José Rogério A. Alves, Cláudio Nahum Lameira, Jerônimo
Published in
Frontiers in Chemistry
Eugenol is a natural compound with well-known repellent activity. However, its pharmaceutical and cosmetic applications are limited, since this compound is highly volatile and thermolabile. Nanoencapsulation provides protection, stability, conservation, and controlled release for several compounds. Here, eugenol was included in β-cyclodextrin, and ...
Abbasi, Mahmoud Alsaikhan, Fahad Obaid, Rasha Fadhel Jahani, Shohreh Biroudian, Saeed Oveisee, Maziar Arab, Mohammad Reza Aramesh-Boroujeni, Zahra Foroughi, Mohammad Mehdi
Published in
Frontiers in Chemistry
In the article presented herein, a deoxyribonucleic acid (DNA) biosensor is introduced for Vincristine determination in pharmaceutical preparations based on the modification of screen printed electrode (SPE) with double-stranded DNA (ds-DNA), polypyrrole (PP), peony-like CuO:Tb3+ nanostructure (P-L CuO:Tb3+ NS). The developed sensor indicated a wid...
Lin, X. Y. Sun, S. H. Liu, Y. T. Shi, Q. Q. Lv, J. J. Peng, Y. J.
Published in
Frontiers in Chemistry
A near-infrared fluorescent probe (LS-NO) for the real-time detection of nitric oxide (NO) in inflammatory bowel disease (IBD) was developed recently. The probe used oligoglycol morpholine-functionalized thiophene as strong electron donors and diaminobenzene (1,2,5-thiadiazole) as a weak electron acceptor and NO trapping group. It could detect exog...
Li, Shirui Wang, Kang Wang, Zeyu Zhang, Wenjie Liu, Zenglin Cheng, Yugang Zhu, Jiankang Zhong, Mingwei Hu, Sanyuan Zhang, Yun
...
Published in
Frontiers in Chemistry
Bioluminescence imaging is a non-invasive technology used to visualize physiological processes in animals and is useful for studying the dynamics of metabolic syndrome. Metabolic syndrome is a broad spectrum of diseases which are rapidly increasing in prevalence, and is closely associated with obesity, type 2 diabetes, nonalcoholic fatty liver dise...
Zheng, Mingyu Zhang, Xiaoping Cheng, Yihao Sun, Lili Zhang, Xinglei
Published in
Frontiers in Chemistry
Collisional activation of protonated phenylalanine derivatives deamination products leads to hydroxyl skeletal rearrangement versus cyclization reaction, and to form hydroxylbenzyl cation via elimination of CH2CO. To better clarify this unusual fragmentation reaction, accurate mass measurements experiments, native isotope experiments, multiple-stag...
Wang, Guangzhao Zhang, Zhaofu Zhang, Yue-Yu Wang, Changhong Qi, Kezhen
Published in
Frontiers in Chemistry
