Okano, Motoki Takahata, Kazue Sugimoto, Junya Muraoka, Shizuko
Published in
Frontiers in Behavioral Neuroscience
In patients with Parkinson’s disease (PD), non-motor symptoms (NMS) including depression and anxiety are often recognized before motor symptoms develop. Monoamine oxidase (MAO)-B inhibitors are therapeutically effective for motor symptoms; however, their effects on NMS in PD are yet to be fully assessed. Here, we aimed to explore the antidepressant...
Banasikowski, Tomek J. Hawken, Emily R.
Published in
Frontiers in Behavioral Neuroscience
A compulsive phenotype characterizes several neuropsychiatric illnesses – including but not limited to – schizophrenia and obsessive compulsive disorder. Because of its perceived etiological heterogeneity, it is challenging to disentangle the specific neurophysiology that precipitates compulsive behaving. Using polydipsia (or non-regulatory water d...
Kanitz, Ellen Tuchscherer, Margret Otten, Winfried Tuchscherer, Armin Zebunke, Manuela Puppe, Birger
Published in
Frontiers in Behavioral Neuroscience
Based on the animal’s reaction to environmental challenges, consistent but different coping styles can be identified, which in turn may have consequences for health and welfare. Therefore, profound knowledge of the complex interrelationships between individual behavioral response patterns, underlying neurobiological mechanisms and immunological eff...
Murkar, Anthony Kent, Pam Cayer, Christian James, Jon Durst, Tony Merali, Zul
Published in
Frontiers in Behavioral Neuroscience
Background: Δ9-Tetrahydrocannabinol (THC, a CB1 receptor agonist) and Cannabidiol (CBD, a non-competitive antagonist of endogenous CB1 and CB2 ligands) are two primary components of Cannabis species, and may modulate fear learning in mammals. The CB1 receptor is widely distributed throughout the cortex and some limbic regions typically associated w...
Yousuf, Hanna Smies, Chad W. Hafenbreidel, Madalyn Tuscher, Jennifer J. Fortress, Ashley M. Frick, Karyn M. Mueller, Devin
Published in
Frontiers in Behavioral Neuroscience
Women are more susceptible to developing cocaine dependence than men, but paradoxically, are more responsive to treatment. The potent estrogen, 17β-estradiol (E2), mediates these effects by augmenting cocaine seeking but also promoting extinction of cocaine seeking through E2’s memory-enhancing functions. Although we have previously shown that E2 f...
Bernabé-Valero, Gloria Blasco-Magraner, José Salvador Moret-Tatay, Carmen
Published in
Frontiers in Behavioral Neuroscience
Acquiring musical skills requires sustained effort over long periods of time. This work aims to explore the variables involved in sustaining motivation in music students, including perceptions about one’s own skills, satisfaction with achievements, effort, the importance of music in one’s life, and perception of the sacrifice made. Two models were ...
Altikulaç, Sibel Bos, Marieke G. N. Foulkes, Lucy Crone, Eveline A. van Hoorn, Jorien
Published in
Frontiers in Behavioral Neuroscience
Adolescence is a sensitive period for socio-cultural processing and a vast literature has established that adolescents are exceptionally attuned to the social context. Theoretical accounts posit that the social reward of social interactions plays a large role in adolescent sensitivity to the social context. Yet, to date it is unclear how sensitivit...
Kompier, Nine F. Keysers, Christian Gazzola, Valeria Lucassen, Paul J. Krugers, Harmen J.
Published in
Frontiers in Behavioral Neuroscience
Exposure to stress during the early postnatal period (i.e., early life stress, ES) can impact brain physiology and modify individual variability in adult social behavior. Arginine vasopressin (AVP) and oxytocin (OXT) are two centrally released neuropeptides that are involved in shaping essential social behaviors, like aggression, social recognition...
Gallo, Meghan Shleifer, Daniel G. Godoy, Livea D. Ofray, Dayshalis Olaniyan, Aliyah Campbell, Talia Bath, Kevin G.
Published in
Frontiers in Behavioral Neuroscience
Early life adversity (ELA) is associated with altered neural development and increased risk for the development of psychopathology across the lifespan. Rodent models of ELA are an important tool for investigating the possible mechanistic underpinnings of pathology development. We used a limited bedding and nesting model (LBN) to induce stress in th...
Yu, Wenjuan Zhu, Min Fang, Hongwei Zhou, Jie Ye, Le Bian, Wenyu Wang, Yuan Zhu, Hui Xiao, Jie Zhu, Hao
...
Published in
Frontiers in Behavioral Neuroscience
MK-801, also known as dizocilpine, is a non-competitive N-methyl-D-aspartic acid (NMDA) receptor antagonist that induces schizophrenia-like symptoms. Our previous study showed that brain-derived neurotrophic factor (BDNF) signaling was upregulated in cultured hippocampal astrocytes in response to MK-801. However, dysfunctional NMDA receptors are ma...
