Chang, Po-Sheng Chou, Hsi-Hsien Lai, Te-Jen Yen, Chi-Hua Pan, Ji-Cyun Lin, Ping-Ting
Published in
Frontiers in Aging Neuroscience
Objectives Dementia is an oxidative stress-related disease. Coenzyme Q10 is a nutrient that occurs naturally in the human body and acts as an antioxidant. The purpose of this study was to investigate the relationships of coenzyme Q10 status, biomarkers for dementia (amyloid β and tau protein), and antioxidant capacity in patients with dementia. Met...
Ölmestig, Joakim Marlet, Ida R. Vilsbøll, Tina Rungby, Jørgen Rostrup, Egill Lambertsen, Kate L. Kruuse, Christina
Published in
Frontiers in Aging Neuroscience
Background and aims Glucagon-like peptide 1 (GLP-1) receptor agonists (GLP-1RA) are widely used for the treatment of type 2 diabetes, and recent studies indicate that they may be cardio- and neuroprotective. The safety and effect of a single dose of exenatide, a short-acting GLP-1RA, on cerebral and peripheral arterial function remain unknown. Meth...
Singh, Padmanabh Barman, Bhabotosh Thakur, Mahendra Kumar
Published in
Frontiers in Aging Neuroscience
Aging and associated neurodegenerative diseases are accompanied by the decline of several brain functions including cognitive abilities. Progressive deleterious changes at biochemical and physiological levels lead to the generation of oxidative stress, accumulation of protein aggregates, mitochondrial dysfunctions, loss of synaptic connections, and...
Yang, Bin Bao, Wenzheng Hong, Shichai
Published in
Frontiers in Aging Neuroscience
Rapid screening and identification of potential candidate compounds are very important to understand the mechanism of drugs for the treatment of Alzheimer's disease (AD) and greatly promote the development of new drugs. In order to greatly improve the success rate of screening and reduce the cost and workload of research and development, this study...
Chen, Leian Niu, Xiaoqian Wang, Yuye Lv, Shuang Zhou, Xiao Yang, Ziyuan Peng, Dantao
Published in
Frontiers in Aging Neuroscience
Objective Detecting plasma tau biomarkers used to be impossible due to their low concentrations in blood samples. Currently, new high-sensitivity assays made it a reality. We performed a systematic review and meta-analysis in order to test the accuracy of plasma tau protein in diagnosing Alzheimer's disease (AD) or mild cognitive impairment (MCI). ...
Wang, Hao Ouyang, Wangbin Liu, Yong Zhang, Minfang Zhao, He Wang, Jian Yin, Zhengqin
Published in
Frontiers in Aging Neuroscience
Purpose The objective quantitation of visual function in patients with advanced retinitis pigmentosa (RP) presents a difficult challenge due to the weak visual function of these patients. This study utilized magnetic resonance imaging (MRI) to assess the function and structure of the visual cortex (VC) in patients with RP and quantitatively categor...
Kang, Ning Shi, Yuanyuan Song, Jiaxi Gao, Fei Fan, Mingyue Jin, Wei Gao, Yaran Lv, Peiyuan
Published in
Frontiers in Aging Neuroscience
Inflammatory responses induced by chronic cerebral hypoperfusion (CCH) play a critical role in the progression of vascular dementia. Stimulator of interferon genes (STING) signaling function as a key mediator of inflammation and immunological responses in the central nervous system (CNS), and resveratrol (RES) exerts potent anti-inflammatory effect...
Zhang, Juan Zhang, Tao Chen, Yu-Chen Chen, Huiyou Feng, Yuan Tang, Wen-Wei Zheng, Jin-Xia
Published in
Frontiers in Aging Neuroscience
Purpose Previous research has found that women with second pregnancy may have an increased risk of cognitive dysfunction. This study aims to investigate the intrinsic functional connectivity (FC) pattern of the DMN anchored on posterior cingulate cortex (PCC) in postpartum women, especially the parous women using resting-state functional magnetic r...
Liu, Xiu-Lin Liu, Shu-Ying Barret, Olivier Tamagnan, Gilles D. Qiao, Hong-Wen Song, Tian-Bing Lu, Jie Chan, Piu
Published in
Frontiers in Aging Neuroscience
Background 18F-FP-DTBZ has been proven as a biomarker for quantifying the concentration of presynaptic vesicular monoamine transporter 2 (VMAT2). However, its clinical application is still limited. Objectives To evaluate the difference in dopaminergic integrity between patients with Parkinson’s disease (PD) and healthy controls (HC) using 18F-FP-DT...
Miyata, Shingo Ishino, Yugo Shimizu, Shoko Tohyama, Masaya
Published in
Frontiers in Aging Neuroscience
Major depressive disorder (MDD) is a multifactorial disease affected by several environmental factors. Although several potential onset hypotheses have been identified, the molecular mechanisms underlying the pathogenesis of this disorder remain unclear. Several recent studies have suggested that among many environmental factors, inflammation and i...
