Purton, Louise E
Published in
Experimental hematology
The founder of all blood cells are hematopoietic stem cells (HSCs), which are rare stem cells that undergo key cell fate decisions to self-renew to generate more HSCs or to differentiate progressively into a hierarchy of different immature hematopoietic cell types to ultimately produce mature blood cells. These decisions are influenced both intrins...
Žemaitis, Kristijonas Subramaniam, Agatheeswaran Galeev, Roman Prosz, Aurel Jassinskaja, Maria Hansson, Jenny Larsson, Jonas
Published in
Experimental hematology
The molecular mechanisms regulating key fate decisions of hematopoietic stem cells (HSCs) remain incompletely understood. Here, we targeted global shRNA libraries to primary human hematopoietic stem and progenitor cells (HSPCs) to screen for modifiers of self-renewal and differentiation, and identified metastasis-associated 1 (MTA1) as a negative r...
Mistry, Jayna J Bowles, Kristian Rushworth, Stuart A
Published in
Experimental hematology
Metabolism impacts all cellular functions and plays a fundamental role in physiology. Metabolic regulation of hematopoiesis is dynamically regulated under steady-state and stress conditions. It is clear that hematopoietic stem cells (HSCs) impose different energy demands and flexibility during maintenance compared with stressed conditions. However,...
Dannenmann, Benjamin Zahabi, Azadeh Mir, Perihan Oswald, Benedikt Bernhard, Regine Klimiankou, Maksim Morishima, Tatsuya Schulze-Osthoff, Klaus Zeidler, Cornelia Kanz, Lothar
...
Published in
Experimental hematology
Qiu, Jiajing Ghaffari, Saghi
Published in
Experimental hematology
The discovery of hematopoietic stem cells (HSCs) heterogeneity has had major implications for investigations of hematopoietic stem cell disorders, clonal hematopoiesis, and HSC aging. More recent studies of the heterogeneity of HSCs' organelles have begun to provide additional insights into HSCs' behavior with far-reaching ramifications for the mec...
Daniely, David Forouzan, Eli Spektor, Tanya M Cohen, Alexa Bitran, Jacob D Chen, Gigi Moezi, Mehdi M Bessudo, Alberto Hrom, John Eshaghian, Shahrooz
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Published in
Experimental hematology
Identifying effective combination regimens is a high priority in multiple myeloma (MM), as most patients eventually become refractory to their current treatments. In this study, we investigated whether the proteasome inhibitor (PI) ixazomib could delay disease progression among patients who failed regimens containing another PI, bortezomib or carfi...
Upadhyay, Pawan Beales, Jeremy Shah, Nakul M Gruszczynska, Agata Miller, Christopher A Petti, Allegra A Ramakrishnan, Sai Mukund Link, Daniel C Ley, Timothy J Welch, John S
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Published in
Experimental hematology
The molecular events responsible for decitabine responses in myelodysplastic syndrome and acute myeloid leukemia patients are poorly understood. Decitabine has a short serum half-life and limited stability in tissue culture. Therefore, theoretical pharmacologic differences may exist between patient molecular changes in vitro and the consequences of...
Kropp, Erin M Li, Qing
Published in
Experimental hematology
Acute myeloid leukemia (AML) is an aggressive disease of clonal hematopoiesis with a high rate of relapse and refractory disease despite intensive therapy. Traditionally, relapsed or refractory AML has increased therapeutic resistance and poor long-term survival. In recent years, advancements in the mechanistic understanding of leukemogenesis have ...
Wilkes, Mark C Scanlon, Vanessa Shibuya, Aya Cepika, Alma-Martina Eskin, Ascia Chen, Zugen Narla, Anupama Glader, Bert Roncarolo, Maria Grazia Nelson, Stanley F
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Published in
Experimental hematology
Diamond-Blackfan Anemia (DBA) is an inherited bone marrow failure syndrome that is associated with anemia, congenital anomalies, and cancer predisposition. It is categorized as a ribosomopathy, because more than 80% or patients have haploinsufficiency of either a small or large subunit-associated ribosomal protein (RP). The erythroid pathology is d...
Sommerkamp, Pia Brown, Jessie A Haltalli, Myriam L R Mercier, François E Vu, Ly P Kranc, Kamil R
Published in
Experimental hematology
Post-transcriptional RNA modifications determine RNA fate by influencing numerous processes such as translation, decay and localization. One of the most abundant RNA modifications is N6-methyladenoside (m6A), which has been shown to be important in healthy as well as malignant hematopoiesis. Several proteins representing key players in m6A RNA biol...
