Wang, Jiaxing Struebing, Felix L Geisert, Eldon E
Published in
Experimental eye research
Glaucoma is a collection of diseases that lead to an irreversible vision loss due to damage of retinal ganglion cells (RGCs). Although the underlying events leading to RGC death are not fully understood, recent research efforts are beginning to define the genetic changes that play a critical role in the initiation and progression of glaucomatous in...
Annamalai, Balasubramaniam Parsons, Nathaniel Nicholson, Crystal Joseph, Kusumam Coughlin, Beth Yang, Xiaofeng Jones, Bryan W Tomlinson, Stephen Rohrer, Bärbel
Published in
Experimental eye research
Age-related macular degeneration is a slowly progressing disease. Studies have tied disease risk to an overactive complement system. We have previously demonstrated that pathology in two mouse models, the choroidal neovascularization (CNV) model and the smoke-induced ocular pathology (SIOP) model, can be reduced by specifically inhibiting the alter...
Colombo, Leonardo Caretti, Anna Dei Cas, Michele Luciano, Francesco Romano, Dario Paroni, Rita Patelli, Fabio Ghidoni, Riccardo Rossetti, Luca
Published in
Experimental eye research
Electrical stimulation (ES) of the eye represents a therapeutic approach in various clinical applications ranging from retinal dystrophies, age-related macular degeneration, retinal artery occlusion and nonarteritic ischemic optic neuropathy. In clinical practice, ES of the eye is mainly performed with a transcorneal or transpalpebral approach. The...
Zhang, Yahan Erhard, Anna Lena Plagemann, Tanja Eter, Nicole Heiduschka, Peter
Published in
Experimental eye research
Microglia are the resident immune cells in the retina. To investigate their properties and behaviour, a reliable and yielding procedure to culture them is necessary. We here describe a way of isolation of microglial cells from the porcine retina, as pig eyes are similar to human eyes in size, structure and vasculature, including similarities in pro...
Guo, Dongwei Jin, Guangming Zhou, Yijing Zhang, Xinyu Cao, Qianzhong Lian, Zhangkai Guo, Yibin Zheng, Danying
Published in
Experimental eye research
To identify the spectrum and frequency of mutations in congenital ectopia lentis (CEL) and to investigate the correlations between genotype and clinical phenotype in Chinese CEL patients. Ninety-three participants with CEL were enrolled from March 2017 to April 2020. Ocular and systemic examinations were performed for each included patient. Genomic...
Liu, Yue Chen, Tao Zheng, Guangying
Published in
Experimental eye research
Posterior capsular opacification (PCO) is the major vision-disrupting complication arising after cataract surgery. Circular RNAs (circRNAs) are biological active RNAs which were involved in various physiological functions. So far, the role of circRNA caspase recruitment domain family member 6 (circ-CARD6) in PCO is still unclear. Quantitative real-...
Escandon, Paulina Vasini, Brenda Whelchel, Amy E Nicholas, Sarah E Matlock, H Greg Ma, Jian-Xing Karamichos, Dimitrios
Published in
Experimental eye research
Peroxisome Proliferator-Activated Receptors (PPARs) are a family of nuclear receptors that play essential roles in modulating cell differentiation, inflammation, and metabolism. Three subtypes of PPARs are known: PPAR-alpha (PPARα), PPAR-gamma (PPARγ), and PPAR-beta/delta (PPARβ/δ). PPARα activation reduces lipid levels and regulates energy homeost...
Liao, Kai Cui, Zekai Zeng, Yong Liu, Jian Wang, Yini Wang, Zhijie Tang, Shibo Chen, Jiansu
Published in
Experimental eye research
Corneal fibroblast can be transformed into corneal myofibroblasts by TGF-β1. Enhancer of zeste homolog 2 (EZH2) upregulation has been observed in the occurrence of other fibrotic disorders. We investigated the role of EZH2 in the progression of corneal fibrosis and the antifibrotic effect of EZH2 inhibition in corneal fibroblasts (CFs). Primary CFs...
Tokuc, Ecem Onder Yuksel, Nursen Rencber, Selenay Furat Ozturk, Ahmet Duruksu, Gokhan Yazir, Yusufhan Ergun, Rıza Emre
Published in
Experimental eye research
It has been reported that citicoline increases antioxidant activity in some tissues. However, the effect of citicoline on corneal wound-healing has not yet been demonstrated. The aim was to investigate the protective effects of citicoline on ultraviolet B (UVB) radiation-induced corneal oxidative damage in a rat model. Four groups (eight animals ea...
Xu, Qiuyun Zhang, Jie Qin, Tingyu Bao, Jingyin Dong, Hongtao Zhou, Xiaorong Hou, Shengping Mao, Liming
Published in
Experimental eye research
Uveitis is a diverse group of sight-threatening intraocular inflammatory diseases usually causing eye redness, pain, blurred vision, and sometimes blindness. Although the exact pathogenesis of uveitis is not yet clear, accumulating evidences have shown that an imbalanced regulation of immune responses caused by a combination of genetic and environm...
