Lee, Seung Min Park, Jong Ho Jang, Chul Hun Byon, Iksoo
Published in
Experimental eye research
The aim of this study was to investigate the efficacy of intravitreal povidone-iodine (PI) in the treatment of vancomycin-resistant Enterococcus faecalis (VRE) endophthalmitis. Fifty New Zealand white rabbits were divided into 5 groups (n = 10 in each group). After the induction of endophthalmitis using VRE (minimum inhibitory concentration [MIC] ≥...
Geoffrion, Dominique Robert, Marie-Claude Chodosh, James Di Polo, Adriana Harissi-Dagher, Mona
Published in
Experimental eye research
Animal models of the Boston keratoprosthesis type 1 (KPro) are needed to study glaucoma damage after KPro implantation to control for confounding comorbidities common in human KPro recipients. The purpose of this study was to determine the feasibility of establishing a reproducible mouse model of glaucoma after KPro surgery, specifically that of a ...
Mukai, Atsushi Otsuki, Yohei Ito, Eiko Fujita, Tomoko Ueno, Morio Maeda, Tadao Kinoshita, Shigeru Sotozono, Chie Hamuro, Junji
Published in
Experimental eye research
To explore new molecular targets for therapy in human model systems by discerning the role of extracellular vesicle (EV) microRNAs (miRs) secreted by human retinal pigment epithelium (hRPE) cells and their cellular interplay with macrophages (Mps). Human Mps differentiated from THP-1 cells stimulated by phorbol myristate acetate were co-cultured wi...
Ji, Shunmei Mao, Xiuyu Zhang, Yifan Ye, Lin Dai, Jinhui
Published in
Experimental eye research
M-opsin, encoded by opn1mw gene, is involved in green-light perception of mice. The role of M-opsin in emmetropization of mice remains uncertain. To answer the above question, 4-week-old wild-type (WT) mice were exposed to white light or green light (460-600 nm, a peak at 510 nm) for 12 weeks. Refractive development was estimated biweekly. After tr...
Shiels, Alan Hejtmancik, J Fielding
Published in
Experimental eye research
Cataract(s) is the clinical equivalent of lens opacity and is caused by light scattering either by high molecular weight protein aggregates in lens cells or disruption of the lens microarchitecture itself. Genetic mutations underlying inherited cataract can provide insight into the biological processes and pathways critical for lens homeostasis and...
Walker, Janice L Menko, A Sue
Published in
Experimental eye research
Immune cells, both tissue resident immune cells and those immune cells recruited in response to wounding or degenerative conditions, are essential to both the maintenance and restoration of homeostasis in most tissues. These cells are typically provided to tissues by their closely associated vasculatures. However, the lens, like many of the tissues...
Wang, Jiaxing Struebing, Felix L Geisert, Eldon E
Published in
Experimental eye research
Glaucoma is a collection of diseases that lead to an irreversible vision loss due to damage of retinal ganglion cells (RGCs). Although the underlying events leading to RGC death are not fully understood, recent research efforts are beginning to define the genetic changes that play a critical role in the initiation and progression of glaucomatous in...
Annamalai, Balasubramaniam Parsons, Nathaniel Nicholson, Crystal Joseph, Kusumam Coughlin, Beth Yang, Xiaofeng Jones, Bryan W Tomlinson, Stephen Rohrer, Bärbel
Published in
Experimental eye research
Age-related macular degeneration is a slowly progressing disease. Studies have tied disease risk to an overactive complement system. We have previously demonstrated that pathology in two mouse models, the choroidal neovascularization (CNV) model and the smoke-induced ocular pathology (SIOP) model, can be reduced by specifically inhibiting the alter...
Colombo, Leonardo Caretti, Anna Dei Cas, Michele Luciano, Francesco Romano, Dario Paroni, Rita Patelli, Fabio Ghidoni, Riccardo Rossetti, Luca
Published in
Experimental eye research
Electrical stimulation (ES) of the eye represents a therapeutic approach in various clinical applications ranging from retinal dystrophies, age-related macular degeneration, retinal artery occlusion and nonarteritic ischemic optic neuropathy. In clinical practice, ES of the eye is mainly performed with a transcorneal or transpalpebral approach. The...
Zhang, Yahan Erhard, Anna Lena Plagemann, Tanja Eter, Nicole Heiduschka, Peter
Published in
Experimental eye research
Microglia are the resident immune cells in the retina. To investigate their properties and behaviour, a reliable and yielding procedure to culture them is necessary. We here describe a way of isolation of microglial cells from the porcine retina, as pig eyes are similar to human eyes in size, structure and vasculature, including similarities in pro...
