Simón, M Victoria Vera, Marcela S Tenconi, Paula E Soto, Tamara Prado Spalm, Facundo H Torlaschi, Camila Mateos, Melina V Rotstein, Nora P
Published in
Experimental eye research
Retinal pigment epithelium (RPE) cells, essential for preserving retina homeostasis, also contribute to the development of retina proliferative diseases, through their exacerbated migration, epithelial to mesenchymal transition (EMT) and inflammatory response. Uncovering the mechanisms inducing these changes is crucial for designing effective treat...
Chiang, Jeremy Chung Bo Goldstein, David Trinh, Terry Au, Kimberley Park, Susanna B Krishnan, Arun V Markoulli, Maria
Published in
Experimental eye research
Neurotoxic chemotherapy has been shown to be associated with reduced corneal nerves and ocular surface discomfort. Substance P is a neuropeptide expressed by sensory nerves including those in the densely innervated cornea. It is involved in both pain signaling and the regulation of epithelial and neural health. While its levels in tear fluids have ...
Grant, Maria B Bernstein, Paul S Boesze-Battaglia, Kathleen Chew, Emily Curcio, Christine A Kenney, M Cristina Klaver, Caroline Philp, Nancy J Rowan, Sheldon Sparrow, Janet
...
Published in
Experimental eye research
Age-related macular degeneration (AMD) is a complex disease with increasing numbers of individuals being afflicted and treatment modalities limited. There are strong interactions between diet, age, the metabolome, and gut microbiota, and all of these have roles in the pathogenesis of AMD. Communication axes exist between the gut microbiota and the ...
Hoerig, Cameron McFadden, Sally Hoang, Quan V Mamou, Jonathan
Published in
Experimental eye research
Myopia alters the microstructural and biomechanical properties of the posterior sclera, which is characterized as a layered structure with potentially different inter-layer collagen fibril characteristics. Scanning acoustic microscopy (SAM) has been used to investigate how the micron-scale bulk mechanical properties of the posterior sclera are affe...
Nikhalashree, Sampath George, Ronnie Shantha, Balekudaru Vijaya, Lingam Sulochana, Konerirajapuram Natarajan Coral, Karunakaran
Published in
Experimental eye research
Long term exposure to anti-glaucoma medications (AGMs) leads to an increase in extracellular matrix (ECM) accumulation in primary glaucoma patients. This study aims to evaluate the effect of topical AGMs in primary human tenon's fibroblasts (HTFs) and analyze the expression of profibrotic and anti-fibrotic proteins. Primary HTFs were cultured from ...
Abdshahzadeh, Hormoz Abrishamchi, Reyhaneh Aydemir, M Enes Hafezi, Nikki Hillen, Mark Torres-Netto, Emilio A Lu, Nan-Ji Hafezi, Farhad
Published in
Experimental eye research
To evaluate whether repeated application of riboflavin during corneal cross-linking (CXL) has an impact on the corneal biomechanical strength in ex-vivo porcine corneas. Laboratory investigation. Sixty-six porcine corneas with intact epithelium were divided into three groups and analyzed. All corneas were pre-soaked with an iso-osmolar solution of ...
Murakami, Tomoya Hoshi, Sujin Okamoto, Fumiki Sakai, Takamasa Katashima, Takuya Naito, Mitsuru Oshika, Tetsuro
Published in
Experimental eye research
Multiple intravitreal injections, which are painful and costly, are often required in the treatment of retinal disorders. Therefore, a novel drug delivery system using hydrogels is currently being evaluated as an alternative. This study aimed to evaluate the ability of tetra-armed polyethylene glycol (tetra-PEG) gel for sustained release in vitro. ...
Pepple, Kathryn L John, Sarah Wilson, Leslie Wang, Victoria Van Gelder, Russell N
Published in
Experimental eye research
Post-infectious uveitis describes the condition of chronic immune mediated ocular inflammation associated with pathogens such as Mycobacterium tuberculosis (Mtb). Mtb associated post-infectious uveitis can be modeled in mice by intravitreal injection of heat-killed Mtb (HKMtb). To better understand how prior systemic exposure to the pathogen alters...
Nakamura, Kenichi Kojima, Sachi Inoue-Mochita, Miyuki Tanihara, Hidenobu Inoue, Toshihiro
Published in
Experimental eye research
We investigated the aqueous humor levels of vascular endothelial growth factor (VEGF), soluble VEGF receptor (sVEGFR)1, and sVEGFR2 in glaucoma patients and the correlations among them. Aqueous humor was collected from the anterior chamber at the start of glaucoma or cataract surgery. The levels of VEGF and its receptors, sVEGFR1 and sVEGFR2, were ...
Zhang, Xueling Qiu, Jini Huang, Feifei Han, Peizhen Shan, Kun Zhang, Chaoran
Published in
Experimental eye research
Uveal melanoma (UM) is the most common primary intraocular tumor with high metastasis and poor prognosis among adults. Hypoxia participates in the metastasis process in various types of cancers. It is reported that the increased expression of hypoxia inducible factor 1 alpha subunit (HIF1A), a hypoxia-related molecule, is associated with worse prog...
