Tvito, Ariella Ronson, Aaron Ghosheh, Renan Kharit, Mira Ashkenazi, Jakob Magen, Sophie Broide, Ellen Benayoun, Emmanuel Rowe, Jacob M. Ofran, Yishai
...
Published in
Experimental Hematology
The Covid-19 pandemic has caused millions of deaths worldwide. Although vaccines have been developed, patients on immunosuppressive therapy are less likely to respond. This study was aimed at investigating the efficacy of a Covid-19 vaccine (Pfizer-BioNTech) in patients with non-Hodgkin lymphoma treated with anti-CD20 monoclonal antibodies. Only 1 ...
Battina, Hanisha L Alentado, Vincent J Srour, Edward F Moliterno, Alison R Kacena, Melissa A
Published in
Experimental hematology
Michaelis, Simon Pichler, Angelika Stelzer, Ingeborg Tinchon, Christoph Enko, Dietmar
Published in
Experimental Hematology
The clinical presentation of patients infected with SARS-CoV-2 is remarkably diverse. Likewise, the underlying pathophysiological mechanisms are proving complex. Disturbances in the blood coagulation system and cytokine storm, such as seen in hemophagocytic syndrome, are among the most serious ones. We present the case of a female 79-year-old patie...
Dausinas, Paige Hartman, Melissa Allman, Lauren O'Leary, Heather
Published in
Experimental Hematology
The SARS-CoV-2 pandemic highlighted a need for in-depth understanding of interaction/identification of receptors and mechanisms/functional consequences of viral binding/entry. SARS-CoV-2 spike protein (SBP) facilitates viral entry via ACE2 and/or NRP1 binding, with DPP4 as a potential co-receptor. These binding partners are expressed on various cel...
Swart, Laura E. Heidenreich, Olaf
Published in
Experimental Hematology
RUNX1/RUNX1T1 is the most common fusion gene found in acute myeloid leukemia. Seminal contributions by many different research groups have revealed a complex regulatory network promoting leukemic self-renewal and propagation. Perturbation of RUNX1/RUNX1T1 levels and its DNA binding affects chromatin accessibility and transcription factor occupation...
Symeonidou, Vasiliki Ottersbach, Katrin
Published in
Experimental Hematology
Infant t(4;11) acute lymphoblastic leukemia is the most common leukemia in infant patients and has a highly aggressive nature. The patients have a dismal prognosis, which has not improved in more than a decade, suggesting that a better understanding of this disease is required. In the study described here, we analyzed two previously published RNA-s...
Ali, Muhammad Ashar Ahmad, Asrar Chaudry, Hafsa Aiman, Wajeeha Aamir, Sobia Anwar, Muhammad Yasir Khan, Anam
Published in
Experimental hematology
Sickle cell disease is prevalent in several parts of the world. Most hospitalizations of these patients are related to pain crisis episodes. Moreover, levels of hemoglobin are lower in sickle cell disease patients as compared with the general population. Complications related to sickle cell disease are managed with blood transfusions, hydroxyurea, ...
Lee-Six, Henry Kent, David G
Published in
Experimental hematology
Despite decades of progress in our understanding of hematopoiesis through the study of animal models and transplantation in humans, investigating physiological human hematopoiesis directly has remained challenging. Questions on the clonal structure of the human hematopoietic stem cell (HSC) pool, such as "how many HSCs are there?" and "do all HSC c...
Kronstein-Wiedemann, Romy Klop, Onny Thiel, Jessica Milanov, Peter Ruhland, Claudia Vermaat, Lars Kocken, Clemens H M Tonn, Torsten Pasini, Erica M
Published in
Experimental hematology
Establishing an in vitro "red blood cell matrix" that would allow uninterrupted access to a stable, homogeneous reticulocyte population would facilitate the establishment of continuous, long-term in vitro Plasmodium vivax blood stage cultures. In this study, we have explored the suitability of the erythroleukemia K562 cell line as a continuous sour...
Hamey, Fiona K Göttgens, Berthold
Published in
Experimental hematology
Hematopoietic stem cells (HSCs) are an essential source and reservoir for normal hematopoiesis, and their function is compromised in many blood disorders. HSC research has benefitted from the recent development of single-cell molecular profiling technologies, where single-cell RNA sequencing (scRNA-seq) in particular has rapidly become an establish...
