Toellner, Kai-Michael
Published in
European journal of immunology
Over the past 25 years it has become clear that B and T lymphocytes go through a range of interactions and migratory events when B cells differentiate to become high-affinity, antibody-secreting cells. This B-cell differentiation is associated with multiple sequential cognate interactions. In this issue of the European Journal of Immunology, Turque...
Maul, Robert W Gearhart, Patricia J
Published in
European journal of immunology
During the immune response, B cells undergo a programed mutagenic cascade to promote increased affinity and expanded antibody function. The two processes, somatic hypermutation (SHM) and class switch recombination (CSR), are initiated by the protein activation-induced deaminase (AID), which converts cytosine to uracil in the immunoglobulin loci. Th...
Rebhandl, Stefan Huemer, Michael Zaborsky, Nadja Gassner, Franz Josef Catakovic, Kemal Felder, Thomas Klaus Greil, Richard Geisberger, Roland
Published in
European journal of immunology
Activation-induced deaminase (AID) is a DNA-mutating enzyme that mediates class-switch recombination as well as somatic hypermutation of antibody genes in B cells. Due to off-target activity, AID is implicated in lymphoma development by introducing genome-wide DNA damage and initiating chromosomal translocations such as c-myc/IgH. Several alternati...
Mearns, Helen Forbes-Blom, Elizabeth E Camberis, Mali Tang, Shiau-Choot Kyle, Ryan Harvie, Marina Kleinschek, Melanie A Le Gros, Graham
Published in
European journal of immunology
A keenly sought therapeutic approach for the treatment of allergic disease is the identification and neutralization of the cytokine that regulates the differentiation of T helper 2 (Th2) cells. Th2 cells are exciting targets for asthma therapies. Recently, the cytokine IL-25 has been shown to enhance Th2-type immune activity and play important role...
Sun, Lei Zhu, Ziyan Cheng, Ni Yan, Qian Ye, Richard D
Published in
European journal of immunology
Interleukin-33 (IL-33), an IL-1 family cytokine and nuclear alarmin, is constitutively expressed in epithelial barrier tissues and human blood vessels. However, little is known about the induced expression of IL-33 in monocytes and macrophages, which are major cytokine-producing cells of the innate immune system. Here, we report the induction of IL...
Kummerow, Carsten Schwarz, Eva C Bufe, Bernd Zufall, Frank Hoth, Markus Qu, Bin
Published in
European journal of immunology
Shiheido, Hirokazu Aoyama, Takane Takahashi, Honami Hanaoka, Kaori Abe, Tomoki Nishida, Emi Chen, Chen Koga, Orie Hikida, Masaki Shibagaki, Yoshio
...
Published in
European journal of immunology
The activation of T cells is known to be accompanied by the temporary downmodulation of the TCR/CD3 complex on the cell surface. Here, we established a novel monoclonal antibody, Dow2, that temporarily induces downmodulation of the TCR/CD3 complex in mouse CD4(+) T cells without activating T cells. Dow2 recognized the determinant on CD3ε; however, ...
Jin, Guang-Bi Winans, Bethany Martin, Kyle C Paige Lawrence, B
Published in
European journal of immunology
The aryl hydrocarbon receptor (AHR) has garnered considerable attention as a modulator of CD4(+) cell lineage development and function. It also regulates antiviral CD8(+) T-cell responses, but via indirect mechanisms that have yet to be determined. Here, we show that during acute influenza virus infection, AHR activation skews dendritic-cell (DC) s...
Al-Banna, Nadia A Vaci, Maria Slauenwhite, Drew Johnston, Brent Issekutz, Thomas B
Published in
European journal of immunology
CCR4 and CXCR3 are expressed on several T-cell subsets in inflamed tissues, yet their role in tissue-specific recruitment is unclear. We examined the contributions of CCR4 and CXCR3 to T-cell recruitment into inflamed joints in collagen-induced arthritis, antigen-draining lymph nodes (LNs) and dermal inflammatory sites (poly I:C, LPS, concanavalin ...
Fujita, Natsuko Oritani, Kenji Ichii, Michiko Yokota, Takafumi Saitoh, Norimitsu Okuzaki, Daisuke Sekine, Yuichi Kon, Shigeyuki Muromoto, Ryuta Saitoh, Kodai
...
Published in
European journal of immunology
Signal-transducing adaptor protein-2 (STAP-2) was cloned as a c-fms/M-CSF receptor interacting protein. STAP-2 is an adaptor protein carrying pleckstrin homology and Src homology 2 like domains, as well as a YXXQ motif. STAP-2 has been indicated to have an ability to bind and modulate a variety of signaling and transcriptional molecules. Especially...
