Riedl, Petra Reiser, Michael Stifter, Katja Krieger, Jana Schirmbeck, Reinhold
Published in
European journal of immunology
Little is known about whether presentation of endogenous and exogenous hepatitis B virus (HBV) surface antigens on APCs targeted by vaccination and/or virus-harboring hepatocytes influences de novo priming of CD8(+) T cells. We showed that surface antigen-expressing transfectants exclusively display a K(b) /S190 epitope, whereas cells pulsed with r...
Snook, Adam E Magee, Michael S Schulz, Stephanie Waldman, Scott A
Published in
European journal of immunology
Self-tolerance, presumably through lineage-unbiased elimination of self-antigen-specific lymphocytes (CD4(+) T, CD8(+) T, and B cells), creates a formidable barrier to cancer immunotherapy. In contrast to this prevailing paradigm, we demonstrate that for some antigens, self-tolerance reflects selective elimination of antigen-specific CD4(+) T cells...
Ross, Ellen M Bourges, Dorothée Hogan, Thea V Gleeson, Paul A van Driel, Ian R
Published in
European journal of immunology
The expression of the Ikaros transcription factor family member, Helios, has been shown to be associated with T-cell tolerance in both the thymus and the periphery. To better understand the importance of Helios in tolerance pathways, we have examined the expression of Helios in TCR-transgenic T cells specific for the gastric H(+) /K(+) ATPase, the ...
Metenou, Simon Coulibaly, Yaya I Sturdevant, Daniel Dolo, Housseini Diallo, Abdallah A Soumaoro, Lamine Coulibaly, Michel E Kanakabandi, Kishore Porcella, Stephen F Klion, Amy D
...
Published in
European journal of immunology
The mechanisms underlying the increase in the numbers of regulatory T (Treg) cells in chronic infection settings remain unclear. Here we have delineated the phenotype and transcriptional profiles of Treg cells from 18 filarial-infected (Fil(+) ) and 19 filarial-uninfected (Fil(-) ) subjects. We found that the frequencies of Foxp3(+) Treg cells expr...
Picco, Gianfranco Beatson, Richard Taylor-Papadimitriou, Joyce Burchell, Joy M
Published in
European journal of immunology
DCs are the most potent APCs and are the focus of many immunotherapeutic approaches for the treatment of cancer, although most of these approaches require the ex vivo generation and pulsing of DCs. We have targeted a subset of DCs in vivo using an Ab to DNGR-1, a C-type lectin dedicated to the cross-presentation of Ag expressed by subsets of DCs. H...
Pick, Jonas Arra, Aditya Lingel, Holger Hegel, J Kolja Huber, Magdalena Nishanth, Gopala Jorch, Gerhard Fischer, Klaus-Dieter Schlüter, Dirk Tedford, Kerry
...
Published in
European journal of immunology
Although CD8(+) T cells that produce IL-17 (Tc17 cells) have been linked to host defense, Tc17 cells show reduced cytotoxic activity, which is the characteristic function of CD8(+) T cells. Here, we show that CTLA-4 enhances the frequency of IL-17 in CD8(+) T cells, indicating that CTLA-4 (CD152) specifically promotes Tc17 differentiation. Simultan...
Cui, Huachun Xie, Na Tan, Zheng Banerjee, Sami Thannickal, Victor John Abraham, Edward Liu, Gang
Published in
European journal of immunology
Long noncoding RNAs (lncRNAs), once thought to be transcriptional noise, have been recently shown to regulate a variety of biological processes. However, there is not much knowledge regarding their roles in the inflammatory response. In this study, we performed human lncRNA microarray assays and identified a number of lncRNAs that demonstrated alte...
Traversari, Catia Sozzani, Silvano Steffensen, Knut R Russo, Vincenzo
Published in
European journal of immunology
Oxysterols are involved in maintaining cellular cholesterol levels. Recently, oxysterols have been demonstrated to modulate the function of immune cells and tumor growth. These effects can be dependent on the activation of the oxysterol-binding liver X receptors (LXRs) or, as recently demonstrated for T and B cells, DCs and neutrophils, can be inde...
Colucci, Francesco Moffett, Ashley Trowsdale, John
Published in
European journal of immunology
Sharif-Paghaleh, Ehsan Leech, John Sunassee, Kavitha Ali, Niwa Sagoo, Pervinder Lechler, Robert I Smyth, Lesley A Lombardi, Giovanna Mullen, Gregory E
Published in
European journal of immunology
DC vaccines have been used to induce tumour-specific cytotoxic T cells . However, this approach to cancer immunotherapy has had limited success. To be successful, injected DCs need to migrate to the LNs where they can stimulate effector T cells . We and others have previously demonstrated by MRI that tumour antigen-pulsed-DCs labelled ex vivo with ...
