Martini, Anna Lisa Carli, Giulia Kiferle, Lorenzo Piersanti, Patrizia Palumbo, Pasquale Morbelli, Silvia Calcagni, Maria Lucia Perani, Daniela Sestini, Stelvio
Published in
European journal of nuclear medicine and molecular imaging
We evaluated brain metabolic dysfunctions and associations with neurological and biological parameters in acute, subacute and chronic COVID-19 phases to provide deeper insights into the pathophysiology of the disease. Twenty-six patients with neurological symptoms (neuro-COVID-19) and [18F]FDG-PET were included. Seven patients were acute (
Lambertini, Alessandro Hartrampf, Philipp E Higuchi, Takahiro Serfling, Sebastian E Meybohm, Patrick Schirbel, Andreas Buck, Andreas K Werner, Rudolf A
Published in
European journal of nuclear medicine and molecular imaging
Cuberas-Borrós, Gemma Roca, Isabel Castell-Conesa, Joan Núñez, Laura Boada, Mercè López, Oscar L Grifols, Carlota Barceló, Miquel Pareto, Deborah Páez, Antonio
...
Published in
European journal of nuclear medicine and molecular imaging
This study was designed to detect structural and functional brain changes in Alzheimer's disease (AD) patients treated with therapeutic plasma exchange (PE) with albumin replacement, as part of the recent AMBAR phase 2b/3 clinical trial. Mild-to-moderate AD patients were randomized into four arms: three arms receiving PE with albumin (one with low-...
Salvadó, Gemma Milà-Alomà, Marta Shekari, Mahnaz Ashton, Nicholas J Operto, Grégory Falcon, Carles Cacciaglia, Raffaele Minguillon, Carolina Fauria, Karine Niñerola-Baizán, Aida
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Published in
European journal of nuclear medicine and molecular imaging
Glial activation is one of the earliest mechanisms to be altered in Alzheimer's disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be measured in both cerebrospinal fluid (CSF) and blood. Plasma GFAP has been suggested to become altered earlier in AD than its CSF counterpart. Although astrocytes consume ap...
Doering, E Hoenig, M C Bischof, G N Bohn, K P Ellingsen, L M van Eimeren, T Drzezga, A
Published in
European journal of nuclear medicine and molecular imaging
In patients with mild cognitive impairment (MCI), enhanced cerebral amyloid-β plaque burden is a high-risk factor to develop dementia with Alzheimer's disease (AD). Not all patients have immediate access to the assessment of amyloid status (A-status) via gold standard methods. It may therefore be of interest to find suitable biomarkers to preselect...
Roosen, Joey Westlund Gotby, Lovisa E L Arntz, Mark J Fütterer, Jurgen J Janssen, Marcel J R Konijnenberg, Mark W van Wijk, Meike W M Overduin, Christiaan G Nijsen, J Frank W
Published in
European journal of nuclear medicine and molecular imaging
Transarterial radioembolization (TARE) is a treatment for liver tumours based on injection of radioactive microspheres in the hepatic arterial system. It is crucial to achieve a maximum tumour dose for an optimal treatment response, while minimizing healthy liver dose to prevent toxicity. There is, however, no intraprocedural feedback on the dose d...
van der Heide, Circe D Dalm, Simone U
Published in
European journal of nuclear medicine and molecular imaging
Targeted radionuclide theranostics is becoming more and more prominent in clinical oncology. Currently, most nuclear medicine compounds researched for cancer theranostics are directed towards targets expressed in only a small subset of cancer types, limiting clinical applicability. The identification of cancer-specific targets that are (more) unive...
Raitza, Matti Alshalali, Aziz A N Glaudemans, Andor W J M Gans, Rijk O B Slart, Riemer H J A
Published in
European journal of nuclear medicine and molecular imaging
Ruigrok, Eline A M Verhoeven, Marjolein Konijnenberg, Mark W de Blois, Erik de Ridder, Corrina M A Stuurman, Debra C Bertarione, Luisa Rolfo, Katia de Jong, Marion Dalm, Simone U
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Published in
European journal of nuclear medicine and molecular imaging
The radiolabeled gastrin-releasing peptide receptor (GRPR)-targeting antagonist NeoB is a promising radioligand for imaging and therapy of GRPR-expressing malignancies. In the current study, we aimed to discover the target organs of toxicity and the radiotoxic effects to these organs, when repeated dosages of [177Lu]Lu-NeoB are administered to heal...
Cen, Peili Zhou, Youyou Cui, Chunyi Wei, Yen Cheng, Zhen Wu, Shuizhu Zhang, Hong Tian, Mei
Published in
European journal of nuclear medicine and molecular imaging
Optical molecular imaging and image-guided theranostics benefit from special and specific imaging agents, for which aggregation-induced emission luminogens (AIEgens) have been regarded as good candidates in many biomedical applications. They display a large Stokes shift, high quantum yield, good biocompatibility, and resistance to photobleaching. N...
