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The QuADRANT study: current status and recommendations for improving uptake and implementation of clinical audit of medi...

Published in European Journal of Nuclear Medicine and Molecular Imaging

[18F]F13640: a selective agonist PET radiopharmaceutical for imaging functional 5-HT1A receptors in humans.

Published in European journal of nuclear medicine and molecular imaging

F13640 (a.k.a. befiradol, NLX-112) is a highly selective 5-HT1A receptor ligand that was selected as a PET radiopharmaceutical-candidate based on animal studies. Due to its high efficacy agonist properties, [18F]F13640 binds preferentially to functional 5-HT1A receptors, which are coupled to intracellular G-proteins. Here, we characterize brain lab...

Positron emission tomography molecular imaging to monitor anti-tumor systemic response for immune checkpoint inhibitor t...

Published in European journal of nuclear medicine and molecular imaging

Immune checkpoint inhibitors (ICIs) achieve a milestone in cancer treatment. Despite the great success of ICI, ICI therapy still faces a big challenge due to heterogeneity of tumor, and therapeutic response is complicated by possible immune-related adverse events (irAEs). Therefore, it is critical to assess the systemic immune response elicited by ...

FDA approval of lecanemab: the real start of widespread amyloid PET use? - the EANM Neuroimaging Committee perspective.

Published in European journal of nuclear medicine and molecular imaging

Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies.

Published in European journal of nuclear medicine and molecular imaging

Pharmacokinetic modelling with arterial sampling is the gold standard for analysing dynamic PET data of the brain. However, the invasive character of arterial sampling prevents its widespread clinical application. Several methods have been developed to avoid arterial sampling, in particular reference region methods. Unfortunately, for some tracers ...

Successful combination of selpercatinib and radioiodine after pretherapeutic dose estimation in RET-altered thyroid carc...

Published in European journal of nuclear medicine and molecular imaging

Voxel-based dosimetry predicting treatment response and related toxicity in HCC patients treated with resin-based Y90 ra...

Published in European journal of nuclear medicine and molecular imaging

There is an increasing body of evidence indicating Y90 dose thresholds for tumor response and treatment-related toxicity. These thresholds are poorly studied in resin Y90, particularly in hepatocellular carcinoma (HCC). To evaluate the efficacy of prospective voxel-based dosimetry for predicting treatment response and adverse events (AEs) in patien...

A comparison of simplified protocols of personalized dosimetry in NEN patients treated by radioligand therapy (RLT) with...

Published in European journal of nuclear medicine and molecular imaging

The role of internal dosimetry is usually proposed for investigational purposes in patients treated by RLT, even if its application is not yet the standard method in clinical practice. This limited use is partially justified by several concomitant factors that make calculations a complex process. Therefore, simplified dosimetry protocols are requir...

PET imaging of animal models with depressive-like phenotypes.

Published in European journal of nuclear medicine and molecular imaging

Major depressive disorder is a growing and poorly understood pathology. Due to technical and ethical limitations, a significant proportion of the research on depressive disorders cannot be performed on patients, but needs to be investigated in animal paradigms. Over the years, animal studies have provided new insight in the mechanisms underlying de...

[18F]FET-PET in children and adolescents with central nervous system tumors: does it support difficult clinical decision...

Published in European journal of nuclear medicine and molecular imaging

Positron emission tomography (PET) with O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) is a well-established tool for non-invasive assessment of adult central nervous system (CNS) tumors. However, data on its diagnostic utility and impact on clinical management in children and adolescents are limited. Twenty-one children and young adults (13 males; m...