Epigenetic reprogramming and blood development.
Published in Epigenomics in February 2015
Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders.
Published in Epigenomics in 2015
Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational modification, which is broadly associated with enhancers and promoters of actively transcribed genomic loci. Recent advances in next-generation sequencing have identified a number of H3K4me regulators mutated in neurodevelopmental disorders including intellect...
Genetic alterations of DNA methylation machinery in human diseases.
Published in Epigenomics in 2015
DNA methylation plays a critical role in the regulation of chromatin structure and gene expression and is involved in a variety of biological processes. The levels and patterns of DNA methylation are regulated by both DNA methyltransferases (DNMT1, DNMT3A and DNMT3B) and 'demethylating' proteins, including the ten-eleven translocation (TET) family ...
Technological advances in epigenomics lead to a better understanding of inflammatory diseases, decitabine and H3K27me3.
Published in Epigenomics in 2015
A study in familial hypercholesterolemia suggests reduced methylomic plasticity in men with coronary artery disease.
Published in Epigenomics in 2015
These results suggest that epigenome-wide changes are associated with CAD occurrence in men.
Epigenetic changes and functional study of HOXA11 in human gastric cancer.
Published in Epigenomics in 2015
Epigenetic silencing of HOXA11 promotes GC proliferation, migration and invasion through activation of Wnt signaling.
DNA methylation of tumor-suppressor miRNA genes in chronic lymphocytic leukemia.
Published in Epigenomics in 2015
DNA methylation is one of the most important epigenetic modifications of the genome involved in the regulation of numerous cellular processes through gene silencing without altering DNA sequences. miRNAs, a class of single-stranded noncoding RNAs of 19-25 nucleotides in length, function as post-transcriptional regulators of gene expression leading ...
Isoform-selective histone deacetylase inhibitors: the trend and promise of disease treatment.
Published in Epigenomics in 2015
Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and ...
...Published in Epigenomics in 2015
The NPC methylome shows a special high-degree CpG methylation epigenotype, similar to the Epstein-Barr virus-infected gastric cancer, indicating a critical epigenetic etiology for NPC pathogenesis.
Polycomb group protein-mediated histone modifications during cell differentiation.
Published in Epigenomics in 2015
Polycomb group (PcG) proteins play an important role in the regulation of gene expression, especially genes encoding lineage-specific factors. Perturbations in PcG protein expression may trigger an unexpected developmental pathway, resulting in birth defects and developmental disabilities. Two Polycomb repressive complexes, PRC1 and PRC2, have been...